Synchronous large gastrointestinal stromal tumor and adenocarcinoma in the stomach treated with imatinib mesylate followed by total gastrectomy

Tsutomu Namikawa, Eri Munekage, Masaya Munekage, Michihiro Maeda, Tomoaki Yatabe, Hiroyuki Kitagawa, Kouichi Sakamoto, Masayuki Obatake, Michiya Kobayashi, Kazuhiro Hanazaki

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Herein we report on a case of synchronous large gastrointestinal stromal tumor (GIST) and adenocarcinoma of the stomach treated with radical surgery following neoadjuvant therapy with imatinib mesylate. A 58-year-old man was referred to our hospital with a large mass in the peritoneal cavity. Abdominal computed tomography showed a large mass measuring 212014 cm in the left upper peritoneal cavity. Esophagogastroduodenoscopy revealed a large elevated lesion in the upper body and a depressed lesion in the lower gastric body near the lesser curvature. Biopsy specimens revealed GIST in the large elevated lesion and signet-ring cell carcinoma in the depressed lesion. Because of the large size of the GIST, the patient was treated with neoadjuvant therapy with imatinib mesylate (400 mg/day) for 5 months. After confirmation of a marked decrease in tumor size following imatinib mesylate therapy, the patient underwent total gastrectomy and regional lymph-node dissection with distal pancreatectomy and splenectomy. Pathological examination confirmed the diagnosis of high-risk GIST and signet-ring cell carcinoma invading the muscularis propria with one lymph-node metastasis. At the time of writing, the patient was receiving postoperative chemotherapy using oral fluoropyrimidine (S-1) without evidence of disease recurrence for 4 months after surgery. In addition to the present case, we provide a retrospective review of another 15 patients who were diagnosed with synchronous GIST in the stomach and primary gastric adenocarcinoma.

Original languageEnglish
Pages (from-to)1855-1859
Number of pages5
JournalAnticancer research
Volume36
Issue number4
Publication statusPublished - 04-2016
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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