Synergistic effects of adenosine A2A antagonist and L-DOPA on rotational behaviors in 6-hydroxydopamine-induced hemi-Parkinsonian mouse model

Takahiro Matsuya; Kazuhiro Takuma; Kosuke Sato; Makoto Asai; Yoshihiro Murakami; Sosuke Miyoshi; Akihiro Noda; Taku Nagai; Hiroyuki Mizoguchi; Shintaro Nishimura; Kiyofumi Yamada

doi:10.1254/jphs.SCZ070058

Synergistic effects of adenosine A_2A antagonist and L-DOPA on rotational behaviors in 6-hydroxydopamine-induced hemi-Parkinsonian mouse model

Takahiro Matsuya, Kazuhiro Takuma, Kosuke Sato, Makoto Asai, Yoshihiro Murakami, Sosuke Miyoshi, Akihiro Noda, Taku Nagai, Hiroyuki Mizoguchi, Shintaro Nishimura, Kiyofumi Yamada

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

In this study, we examined the combination effects of L-DOPA and adenosine receptor antagonists on rotational behaviors in a hemi-Parkinsonian mouse model induced by unilateral 6-hydroxydopamine (6-OHDA) injection. The adenosine A _2A antagonist SCH-58261, but not the A₁-receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine or A_2B-receptor antagonist alloxazine, synergistically potentiated the L-DOPA-induced rotational behaviors in the 6-OHDA-lesioned mice. In addtion, the 6-OHDA-induced lesions of the dopaminergic system did not affect the in vivo binding of an adenosine A_2A-receptor tracer [¹¹C]SCH-442416 in the striatatum. These findings suggest that adenosine A_2A antagonists are extremely useful for pharmacotherapy of L-DOPA in Parkinson's disease patients.

Original language	English
Pages (from-to)	329-332
Number of pages	4
Journal	Journal of Pharmacological Sciences
Volume	103
Issue number	3
DOIs	https://doi.org/10.1254/jphs.SCZ070058
Publication status	Published - 2007
Externally published	Yes

All Science Journal Classification (ASJC) codes

Molecular Medicine
Pharmacology

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Matsuya, T., Takuma, K., Sato, K., Asai, M., Murakami, Y., Miyoshi, S., Noda, A., Nagai, T., Mizoguchi, H., Nishimura, S., & Yamada, K. (2007). Synergistic effects of adenosine A_2A antagonist and L-DOPA on rotational behaviors in 6-hydroxydopamine-induced hemi-Parkinsonian mouse model. Journal of Pharmacological Sciences, 103(3), 329-332. https://doi.org/10.1254/jphs.SCZ070058

Matsuya, Takahiro ; Takuma, Kazuhiro ; Sato, Kosuke ; Asai, Makoto ; Murakami, Yoshihiro ; Miyoshi, Sosuke ; Noda, Akihiro ; Nagai, Taku ; Mizoguchi, Hiroyuki ; Nishimura, Shintaro ; Yamada, Kiyofumi. / Synergistic effects of adenosine A_2A antagonist and L-DOPA on rotational behaviors in 6-hydroxydopamine-induced hemi-Parkinsonian mouse model. In: Journal of Pharmacological Sciences. 2007 ; Vol. 103, No. 3. pp. 329-332.

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title = "Synergistic effects of adenosine A2A antagonist and L-DOPA on rotational behaviors in 6-hydroxydopamine-induced hemi-Parkinsonian mouse model",

abstract = "In this study, we examined the combination effects of L-DOPA and adenosine receptor antagonists on rotational behaviors in a hemi-Parkinsonian mouse model induced by unilateral 6-hydroxydopamine (6-OHDA) injection. The adenosine A 2A antagonist SCH-58261, but not the A1-receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine or A2B-receptor antagonist alloxazine, synergistically potentiated the L-DOPA-induced rotational behaviors in the 6-OHDA-lesioned mice. In addtion, the 6-OHDA-induced lesions of the dopaminergic system did not affect the in vivo binding of an adenosine A2A-receptor tracer [11C]SCH-442416 in the striatatum. These findings suggest that adenosine A2A antagonists are extremely useful for pharmacotherapy of L-DOPA in Parkinson's disease patients.",

author = "Takahiro Matsuya and Kazuhiro Takuma and Kosuke Sato and Makoto Asai and Yoshihiro Murakami and Sosuke Miyoshi and Akihiro Noda and Taku Nagai and Hiroyuki Mizoguchi and Shintaro Nishimura and Kiyofumi Yamada",

year = "2007",

doi = "10.1254/jphs.SCZ070058",

language = "English",

volume = "103",

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Matsuya, T, Takuma, K, Sato, K, Asai, M, Murakami, Y, Miyoshi, S, Noda, A, Nagai, T, Mizoguchi, H, Nishimura, S & Yamada, K 2007, 'Synergistic effects of adenosine A_2A antagonist and L-DOPA on rotational behaviors in 6-hydroxydopamine-induced hemi-Parkinsonian mouse model', Journal of Pharmacological Sciences, vol. 103, no. 3, pp. 329-332. https://doi.org/10.1254/jphs.SCZ070058

Synergistic effects of adenosine A_2A antagonist and L-DOPA on rotational behaviors in 6-hydroxydopamine-induced hemi-Parkinsonian mouse model. / Matsuya, Takahiro; Takuma, Kazuhiro; Sato, Kosuke; Asai, Makoto; Murakami, Yoshihiro; Miyoshi, Sosuke; Noda, Akihiro; Nagai, Taku; Mizoguchi, Hiroyuki; Nishimura, Shintaro; Yamada, Kiyofumi.

In: Journal of Pharmacological Sciences, Vol. 103, No. 3, 2007, p. 329-332.

Research output: Contribution to journal › Article › peer-review

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AU - Matsuya, Takahiro

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AU - Sato, Kosuke

AU - Asai, Makoto

AU - Murakami, Yoshihiro

AU - Miyoshi, Sosuke

AU - Noda, Akihiro

AU - Nagai, Taku

AU - Mizoguchi, Hiroyuki

AU - Nishimura, Shintaro

AU - Yamada, Kiyofumi

PY - 2007

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AB - In this study, we examined the combination effects of L-DOPA and adenosine receptor antagonists on rotational behaviors in a hemi-Parkinsonian mouse model induced by unilateral 6-hydroxydopamine (6-OHDA) injection. The adenosine A 2A antagonist SCH-58261, but not the A1-receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine or A2B-receptor antagonist alloxazine, synergistically potentiated the L-DOPA-induced rotational behaviors in the 6-OHDA-lesioned mice. In addtion, the 6-OHDA-induced lesions of the dopaminergic system did not affect the in vivo binding of an adenosine A2A-receptor tracer [11C]SCH-442416 in the striatatum. These findings suggest that adenosine A2A antagonists are extremely useful for pharmacotherapy of L-DOPA in Parkinson's disease patients.

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