Synergistic effects of adenosine A2A antagonist and L-DOPA on rotational behaviors in 6-hydroxydopamine-induced hemi-Parkinsonian mouse model

Takahiro Matsuya, Kazuhiro Takuma, Kosuke Sato, Makoto Asai, Yoshihiro Murakami, Sosuke Miyoshi, Akihiro Noda, Taku Nagai, Hiroyuki Mizoguchi, Shintaro Nishimura, Kiyofumi Yamada

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

In this study, we examined the combination effects of L-DOPA and adenosine receptor antagonists on rotational behaviors in a hemi-Parkinsonian mouse model induced by unilateral 6-hydroxydopamine (6-OHDA) injection. The adenosine A 2A antagonist SCH-58261, but not the A1-receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine or A2B-receptor antagonist alloxazine, synergistically potentiated the L-DOPA-induced rotational behaviors in the 6-OHDA-lesioned mice. In addtion, the 6-OHDA-induced lesions of the dopaminergic system did not affect the in vivo binding of an adenosine A2A-receptor tracer [11C]SCH-442416 in the striatatum. These findings suggest that adenosine A2A antagonists are extremely useful for pharmacotherapy of L-DOPA in Parkinson's disease patients.

Original languageEnglish
Pages (from-to)329-332
Number of pages4
JournalJournal of Pharmacological Sciences
Volume103
Issue number3
DOIs
Publication statusPublished - 2007
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

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