TY - JOUR
T1 - Synergistic effects of adenosine A2A antagonist and L-DOPA on rotational behaviors in 6-hydroxydopamine-induced hemi-Parkinsonian mouse model
AU - Matsuya, Takahiro
AU - Takuma, Kazuhiro
AU - Sato, Kosuke
AU - Asai, Makoto
AU - Murakami, Yoshihiro
AU - Miyoshi, Sosuke
AU - Noda, Akihiro
AU - Nagai, Taku
AU - Mizoguchi, Hiroyuki
AU - Nishimura, Shintaro
AU - Yamada, Kiyofumi
N1 - Copyright:
Copyright 2009 Elsevier B.V., All rights reserved.
PY - 2007
Y1 - 2007
N2 - In this study, we examined the combination effects of L-DOPA and adenosine receptor antagonists on rotational behaviors in a hemi-Parkinsonian mouse model induced by unilateral 6-hydroxydopamine (6-OHDA) injection. The adenosine A 2A antagonist SCH-58261, but not the A1-receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine or A2B-receptor antagonist alloxazine, synergistically potentiated the L-DOPA-induced rotational behaviors in the 6-OHDA-lesioned mice. In addtion, the 6-OHDA-induced lesions of the dopaminergic system did not affect the in vivo binding of an adenosine A2A-receptor tracer [11C]SCH-442416 in the striatatum. These findings suggest that adenosine A2A antagonists are extremely useful for pharmacotherapy of L-DOPA in Parkinson's disease patients.
AB - In this study, we examined the combination effects of L-DOPA and adenosine receptor antagonists on rotational behaviors in a hemi-Parkinsonian mouse model induced by unilateral 6-hydroxydopamine (6-OHDA) injection. The adenosine A 2A antagonist SCH-58261, but not the A1-receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine or A2B-receptor antagonist alloxazine, synergistically potentiated the L-DOPA-induced rotational behaviors in the 6-OHDA-lesioned mice. In addtion, the 6-OHDA-induced lesions of the dopaminergic system did not affect the in vivo binding of an adenosine A2A-receptor tracer [11C]SCH-442416 in the striatatum. These findings suggest that adenosine A2A antagonists are extremely useful for pharmacotherapy of L-DOPA in Parkinson's disease patients.
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U2 - 10.1254/jphs.SCZ070058
DO - 10.1254/jphs.SCZ070058
M3 - Article
C2 - 17341841
AN - SCOPUS:33947505232
VL - 103
SP - 329
EP - 332
JO - Journal of Pharmacological Sciences
JF - Journal of Pharmacological Sciences
SN - 1347-8613
IS - 3
ER -