Synovial fluid concentrations of the C-propeptide of type II collagen correlate with body mass index in primary knee osteoarthritis

Tatsuo Kobayashi, Yasuo Yoshihara, Atsuyoshi Samura, Harumoto Yamada, Masayuki Shinmei, Harald Roos, L. Stefan Lohmander

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Abstract

Objective - To explore in a cross sectional study in patients with primary knee osteoarthritis (OA) the relations between body mass index (BMI), disease stage, and the concentrations of a putative joint fluid marker of type II collagen synthesis, procollagen II C-propeptide. Patients and Methods - The study included 142 patients with knee OA (median age 68, median BMI 24.1). OA was staged radiologically. The concentrations in synovial fluid of procollagen II C-propeptide were measured by a sandwich enzyme immunoassay. Results - Joint fluid concentrations of procollagen II C-propeptide were in creased in knees with OA (median 3.7 ng/ml), compared with published reference values for knees in healthy adult volunteers (median 1.3 ng/ml). The concentrations of procollagen II C-propeptide were independently related to both OA stage and BMI (Γ = 0.343, p < 0.0001 and Γ, = 0.253, p = 0.002, respectively). Conclusions - Joint fluid concentrations of this putative marker of collagen II synthesis are high in early and mid-stage OA, but decrease in end stage disease. In addition and for the first time it was shown that the concentrations in synovial fluid of procollagen II C- propeptide increase with increasing BMI in primary knee OA. The increased joint fluid values of this marker in patients with primary knee OA and a high BMI, may reflect increased rates of collagen synthesis in their joint cartilage and could relate to the previously shown increased risk for disease progression in such patients.

Original languageEnglish
Pages (from-to)500-503
Number of pages4
JournalAnnals of the Rheumatic Diseases
Volume56
Issue number8
DOIs
Publication statusPublished - 01-01-1997

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Knee Osteoarthritis
Synovial Fluid
Body Mass Index
Joints
Fluids
Osteoarthritis
Collagen
Collagen Type II
Immunoenzyme Techniques
Cartilage
Disease Progression
Knee
Healthy Volunteers
Reference Values
Cross-Sectional Studies
procollagen type II carboxy-terminal peptide
chondrocalcin
Enzymes

All Science Journal Classification (ASJC) codes

  • Rheumatology
  • Immunology and Allergy
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Kobayashi, Tatsuo ; Yoshihara, Yasuo ; Samura, Atsuyoshi ; Yamada, Harumoto ; Shinmei, Masayuki ; Roos, Harald ; Lohmander, L. Stefan. / Synovial fluid concentrations of the C-propeptide of type II collagen correlate with body mass index in primary knee osteoarthritis. In: Annals of the Rheumatic Diseases. 1997 ; Vol. 56, No. 8. pp. 500-503.
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abstract = "Objective - To explore in a cross sectional study in patients with primary knee osteoarthritis (OA) the relations between body mass index (BMI), disease stage, and the concentrations of a putative joint fluid marker of type II collagen synthesis, procollagen II C-propeptide. Patients and Methods - The study included 142 patients with knee OA (median age 68, median BMI 24.1). OA was staged radiologically. The concentrations in synovial fluid of procollagen II C-propeptide were measured by a sandwich enzyme immunoassay. Results - Joint fluid concentrations of procollagen II C-propeptide were in creased in knees with OA (median 3.7 ng/ml), compared with published reference values for knees in healthy adult volunteers (median 1.3 ng/ml). The concentrations of procollagen II C-propeptide were independently related to both OA stage and BMI (Γ = 0.343, p < 0.0001 and Γ, = 0.253, p = 0.002, respectively). Conclusions - Joint fluid concentrations of this putative marker of collagen II synthesis are high in early and mid-stage OA, but decrease in end stage disease. In addition and for the first time it was shown that the concentrations in synovial fluid of procollagen II C- propeptide increase with increasing BMI in primary knee OA. The increased joint fluid values of this marker in patients with primary knee OA and a high BMI, may reflect increased rates of collagen synthesis in their joint cartilage and could relate to the previously shown increased risk for disease progression in such patients.",
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Synovial fluid concentrations of the C-propeptide of type II collagen correlate with body mass index in primary knee osteoarthritis. / Kobayashi, Tatsuo; Yoshihara, Yasuo; Samura, Atsuyoshi; Yamada, Harumoto; Shinmei, Masayuki; Roos, Harald; Lohmander, L. Stefan.

In: Annals of the Rheumatic Diseases, Vol. 56, No. 8, 01.01.1997, p. 500-503.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Synovial fluid concentrations of the C-propeptide of type II collagen correlate with body mass index in primary knee osteoarthritis

AU - Kobayashi, Tatsuo

AU - Yoshihara, Yasuo

AU - Samura, Atsuyoshi

AU - Yamada, Harumoto

AU - Shinmei, Masayuki

AU - Roos, Harald

AU - Lohmander, L. Stefan

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N2 - Objective - To explore in a cross sectional study in patients with primary knee osteoarthritis (OA) the relations between body mass index (BMI), disease stage, and the concentrations of a putative joint fluid marker of type II collagen synthesis, procollagen II C-propeptide. Patients and Methods - The study included 142 patients with knee OA (median age 68, median BMI 24.1). OA was staged radiologically. The concentrations in synovial fluid of procollagen II C-propeptide were measured by a sandwich enzyme immunoassay. Results - Joint fluid concentrations of procollagen II C-propeptide were in creased in knees with OA (median 3.7 ng/ml), compared with published reference values for knees in healthy adult volunteers (median 1.3 ng/ml). The concentrations of procollagen II C-propeptide were independently related to both OA stage and BMI (Γ = 0.343, p < 0.0001 and Γ, = 0.253, p = 0.002, respectively). Conclusions - Joint fluid concentrations of this putative marker of collagen II synthesis are high in early and mid-stage OA, but decrease in end stage disease. In addition and for the first time it was shown that the concentrations in synovial fluid of procollagen II C- propeptide increase with increasing BMI in primary knee OA. The increased joint fluid values of this marker in patients with primary knee OA and a high BMI, may reflect increased rates of collagen synthesis in their joint cartilage and could relate to the previously shown increased risk for disease progression in such patients.

AB - Objective - To explore in a cross sectional study in patients with primary knee osteoarthritis (OA) the relations between body mass index (BMI), disease stage, and the concentrations of a putative joint fluid marker of type II collagen synthesis, procollagen II C-propeptide. Patients and Methods - The study included 142 patients with knee OA (median age 68, median BMI 24.1). OA was staged radiologically. The concentrations in synovial fluid of procollagen II C-propeptide were measured by a sandwich enzyme immunoassay. Results - Joint fluid concentrations of procollagen II C-propeptide were in creased in knees with OA (median 3.7 ng/ml), compared with published reference values for knees in healthy adult volunteers (median 1.3 ng/ml). The concentrations of procollagen II C-propeptide were independently related to both OA stage and BMI (Γ = 0.343, p < 0.0001 and Γ, = 0.253, p = 0.002, respectively). Conclusions - Joint fluid concentrations of this putative marker of collagen II synthesis are high in early and mid-stage OA, but decrease in end stage disease. In addition and for the first time it was shown that the concentrations in synovial fluid of procollagen II C- propeptide increase with increasing BMI in primary knee OA. The increased joint fluid values of this marker in patients with primary knee OA and a high BMI, may reflect increased rates of collagen synthesis in their joint cartilage and could relate to the previously shown increased risk for disease progression in such patients.

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