Abstract
Objective - To explore in a cross sectional study in patients with primary knee osteoarthritis (OA) the relations between body mass index (BMI), disease stage, and the concentrations of a putative joint fluid marker of type II collagen synthesis, procollagen II C-propeptide. Patients and Methods - The study included 142 patients with knee OA (median age 68, median BMI 24.1). OA was staged radiologically. The concentrations in synovial fluid of procollagen II C-propeptide were measured by a sandwich enzyme immunoassay. Results - Joint fluid concentrations of procollagen II C-propeptide were in creased in knees with OA (median 3.7 ng/ml), compared with published reference values for knees in healthy adult volunteers (median 1.3 ng/ml). The concentrations of procollagen II C-propeptide were independently related to both OA stage and BMI (Γ = 0.343, p < 0.0001 and Γ, = 0.253, p = 0.002, respectively). Conclusions - Joint fluid concentrations of this putative marker of collagen II synthesis are high in early and mid-stage OA, but decrease in end stage disease. In addition and for the first time it was shown that the concentrations in synovial fluid of procollagen II C- propeptide increase with increasing BMI in primary knee OA. The increased joint fluid values of this marker in patients with primary knee OA and a high BMI, may reflect increased rates of collagen synthesis in their joint cartilage and could relate to the previously shown increased risk for disease progression in such patients.
| Original language | English |
|---|---|
| Pages (from-to) | 500-503 |
| Number of pages | 4 |
| Journal | Annals of the Rheumatic Diseases |
| Volume | 56 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 01-01-1997 |
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All Science Journal Classification (ASJC) codes
- Rheumatology
- Immunology and Allergy
- Immunology
- Biochemistry, Genetics and Molecular Biology(all)
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Synovial fluid concentrations of the C-propeptide of type II collagen correlate with body mass index in primary knee osteoarthritis. / Kobayashi, Tatsuo; Yoshihara, Yasuo; Samura, Atsuyoshi; Yamada, Harumoto; Shinmei, Masayuki; Roos, Harald; Lohmander, L. Stefan.
In: Annals of the Rheumatic Diseases, Vol. 56, No. 8, 01.01.1997, p. 500-503.Research output: Contribution to journal › Article
TY - JOUR
T1 - Synovial fluid concentrations of the C-propeptide of type II collagen correlate with body mass index in primary knee osteoarthritis
AU - Kobayashi, Tatsuo
AU - Yoshihara, Yasuo
AU - Samura, Atsuyoshi
AU - Yamada, Harumoto
AU - Shinmei, Masayuki
AU - Roos, Harald
AU - Lohmander, L. Stefan
PY - 1997/1/1
Y1 - 1997/1/1
N2 - Objective - To explore in a cross sectional study in patients with primary knee osteoarthritis (OA) the relations between body mass index (BMI), disease stage, and the concentrations of a putative joint fluid marker of type II collagen synthesis, procollagen II C-propeptide. Patients and Methods - The study included 142 patients with knee OA (median age 68, median BMI 24.1). OA was staged radiologically. The concentrations in synovial fluid of procollagen II C-propeptide were measured by a sandwich enzyme immunoassay. Results - Joint fluid concentrations of procollagen II C-propeptide were in creased in knees with OA (median 3.7 ng/ml), compared with published reference values for knees in healthy adult volunteers (median 1.3 ng/ml). The concentrations of procollagen II C-propeptide were independently related to both OA stage and BMI (Γ = 0.343, p < 0.0001 and Γ, = 0.253, p = 0.002, respectively). Conclusions - Joint fluid concentrations of this putative marker of collagen II synthesis are high in early and mid-stage OA, but decrease in end stage disease. In addition and for the first time it was shown that the concentrations in synovial fluid of procollagen II C- propeptide increase with increasing BMI in primary knee OA. The increased joint fluid values of this marker in patients with primary knee OA and a high BMI, may reflect increased rates of collagen synthesis in their joint cartilage and could relate to the previously shown increased risk for disease progression in such patients.
AB - Objective - To explore in a cross sectional study in patients with primary knee osteoarthritis (OA) the relations between body mass index (BMI), disease stage, and the concentrations of a putative joint fluid marker of type II collagen synthesis, procollagen II C-propeptide. Patients and Methods - The study included 142 patients with knee OA (median age 68, median BMI 24.1). OA was staged radiologically. The concentrations in synovial fluid of procollagen II C-propeptide were measured by a sandwich enzyme immunoassay. Results - Joint fluid concentrations of procollagen II C-propeptide were in creased in knees with OA (median 3.7 ng/ml), compared with published reference values for knees in healthy adult volunteers (median 1.3 ng/ml). The concentrations of procollagen II C-propeptide were independently related to both OA stage and BMI (Γ = 0.343, p < 0.0001 and Γ, = 0.253, p = 0.002, respectively). Conclusions - Joint fluid concentrations of this putative marker of collagen II synthesis are high in early and mid-stage OA, but decrease in end stage disease. In addition and for the first time it was shown that the concentrations in synovial fluid of procollagen II C- propeptide increase with increasing BMI in primary knee OA. The increased joint fluid values of this marker in patients with primary knee OA and a high BMI, may reflect increased rates of collagen synthesis in their joint cartilage and could relate to the previously shown increased risk for disease progression in such patients.
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U2 - 10.1136/ard.56.8.500
DO - 10.1136/ard.56.8.500
M3 - Article
VL - 56
SP - 500
EP - 503
JO - Annals of the Rheumatic Diseases
JF - Annals of the Rheumatic Diseases
SN - 0003-4967
IS - 8
ER -