Synthesis of new sugar derivatives and evaluation of their antibacterial activities against Mycobacterium tuberculosis

Yasuhiro Horita, Takemasa Takii, Taku Chiba, Ryuji Kuroishi, Yasuhiro Maeda, Yukihisa Kurono, Emi Inagaki, Kenji Nishimura, Yoshifumi Yamamoto, Chiyoji Abe, Masami Mori, Kikuo Onozaki

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

A series of sugar derivatives (1-13) were synthesized and evaluated for antibacterial activity against Mycobacterium tuberculosis (MTB), especially multi-drug resistant (MDR) MTB, and the structure-activity relationships of these compounds were studied. The results showed that the compound OCT313 (2-acetamido-2deoxy-β-d-glucopyranosyl N,N-dimethyldithiocarbamate) (4) exhibited significant in vitro bactericidal activity, and that the dithiocarbamate group at C-1 position of the glucopyranoside ring was requisite for the antibacterial activity.

Original languageEnglish
Pages (from-to)6313-6316
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume19
Issue number22
DOIs
Publication statusPublished - 2009
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Synthesis of new sugar derivatives and evaluation of their antibacterial activities against Mycobacterium tuberculosis'. Together they form a unique fingerprint.

Cite this