Synthetic nucleosides and nucleotides. xxxi.1inhibitory effects of 2’-deoxy-5-styryluridine 5’-triphosphate analogues on retroviral reverse transcriptases and higher eukaryotic dna polymerases

Tovofumi Yamaguchi, Shunji Izuta, Motoshi Suzuki, Shonen Yoshida, Akio Matsukage, Mineo Saneyoshi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Some new 5’-triphosphate derivatives of 2',3'-dideoxy-5-styryluridine analogues have been synthesized and examined for their inhibitory effects on retroviral reverse transcriptases and eukaryotic DNA polymerases. We describe here the mode of inhibition and the influence of the substituent at the 5-position of uracil ring of 2',3’-dideoxyUTP analogues.

Original languageEnglish
Pages (from-to)1247-1258
Number of pages12
JournalNucleosides and Nucleotides
Volume13
Issue number6-7
DOIs
Publication statusPublished - 01-07-1994

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Genetics

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