Systemic cytokine responses in patients with influenza-associated encephalopathy

Jun Ichi Kawada, Hiroshi Kimura, Yoshinori Ito, Shinya Hara, Masahiro Iriyama, Tetsushi Yoshikawa, Tsuneo Morishima

Research output: Contribution to journalArticle

102 Citations (Scopus)

Abstract

Influenza-associated encephalopathy, a severe neurologic complication of influenza, is being reported more frequently in Japan. We investigated the transcription of cytokine genes in peripheral blood leukocytes and compared patients with influenza and with encephalopathy or febrile convulsions and patients with influenza but without neurologic complications. A quantitative polymerase chain reaction (PCR) revealed that transcription of the interleukin (IL)-6, IL-10, and tumor necrosis factor-α genes was up-regulated to a greater extent in patients with encephalopathy than in those without neurologic complications. Plasma IL-6 levels also were higher in patients with encephalopathy, although the difference was marginal. Viral RNA in throat swabs was quantified using a real-time quantitative PCR. The virus load was similar among patients with encephalopathy or febrile convulsions or without neurologic complications. Furthermore, virus load was not correlated with either the transcription of cytokine genes or plasma cytokine concentrations. These results suggest that influenza-associated encephalopathy might be a consequence of systemic immune responses.

Original languageEnglish
Pages (from-to)690-698
Number of pages9
JournalJournal of Infectious Diseases
Volume188
Issue number5
DOIs
Publication statusPublished - 01-09-2003

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Brain Diseases
Human Influenza
Cytokines
Nervous System
Febrile Seizures
Interleukin-6
Genes
Viruses
Viral RNA
Pharynx
Interleukin-10
Real-Time Polymerase Chain Reaction
Japan
Leukocytes
Tumor Necrosis Factor-alpha
Polymerase Chain Reaction

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Kawada, J. I., Kimura, H., Ito, Y., Hara, S., Iriyama, M., Yoshikawa, T., & Morishima, T. (2003). Systemic cytokine responses in patients with influenza-associated encephalopathy. Journal of Infectious Diseases, 188(5), 690-698. https://doi.org/10.1086/377101
Kawada, Jun Ichi ; Kimura, Hiroshi ; Ito, Yoshinori ; Hara, Shinya ; Iriyama, Masahiro ; Yoshikawa, Tetsushi ; Morishima, Tsuneo. / Systemic cytokine responses in patients with influenza-associated encephalopathy. In: Journal of Infectious Diseases. 2003 ; Vol. 188, No. 5. pp. 690-698.
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Kawada, JI, Kimura, H, Ito, Y, Hara, S, Iriyama, M, Yoshikawa, T & Morishima, T 2003, 'Systemic cytokine responses in patients with influenza-associated encephalopathy', Journal of Infectious Diseases, vol. 188, no. 5, pp. 690-698. https://doi.org/10.1086/377101

Systemic cytokine responses in patients with influenza-associated encephalopathy. / Kawada, Jun Ichi; Kimura, Hiroshi; Ito, Yoshinori; Hara, Shinya; Iriyama, Masahiro; Yoshikawa, Tetsushi; Morishima, Tsuneo.

In: Journal of Infectious Diseases, Vol. 188, No. 5, 01.09.2003, p. 690-698.

Research output: Contribution to journalArticle

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