TY - JOUR
T1 - T cell progenitors emerge earlier than B cell progenitors in the murine fetal liver
AU - Kawamoto, Hiroshi
AU - Ikawa, Tomokatsu
AU - Ohmura, Koichiro
AU - Fujimoto, Shinji
AU - Katsura, Yoshimoto
N1 - Funding Information:
We thank Drs. S. Fairchild (Fukui Medical School) and W. T. V. Germeraad (University Hospital Utrechit) for reading the manuscript, and Ms. Y. Takaoki for secretarial assistance. This work was supported by Grants-in-Aid from the Ministry of Education, Science, Sports, and Culture of Japan.
PY - 2000
Y1 - 2000
N2 - The developmental potential of individual cells in the Lin-c-kit+CD45+IL-7R+ (IL-7R+) population from murine fetal liver was investigated using a clonal assay capable of determining the potential of a progenitor to give rise to myeloid, T, and B cells. Unipotent progenitors generating T cells (p-T) or B cells (p-B) but not other types of progenitors were found in the IL-7R+ population. A large proportion of progenitors at day 12 of gestation are p-T, whereas the frequency of p-T dramatically decreases with gestational age. In marked contrast, p-B are very rare by day 12, but they rapidly increase thereafter. These findings strongly suggest that the commitment of multipotent progenitors to T and B cell lineages occurs independently.
AB - The developmental potential of individual cells in the Lin-c-kit+CD45+IL-7R+ (IL-7R+) population from murine fetal liver was investigated using a clonal assay capable of determining the potential of a progenitor to give rise to myeloid, T, and B cells. Unipotent progenitors generating T cells (p-T) or B cells (p-B) but not other types of progenitors were found in the IL-7R+ population. A large proportion of progenitors at day 12 of gestation are p-T, whereas the frequency of p-T dramatically decreases with gestational age. In marked contrast, p-B are very rare by day 12, but they rapidly increase thereafter. These findings strongly suggest that the commitment of multipotent progenitors to T and B cell lineages occurs independently.
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U2 - 10.1016/S1074-7613(00)80196-X
DO - 10.1016/S1074-7613(00)80196-X
M3 - Article
C2 - 10795742
AN - SCOPUS:0033681860
SN - 1074-7613
VL - 12
SP - 441
EP - 450
JO - Immunity
JF - Immunity
IS - 4
ER -