T cell progenitors emerge earlier than B cell progenitors in the murine fetal liver

Hiroshi Kawamoto, Tomokatsu Ikawa, Koichiro Ohmura, Shinji Fujimoto, Yoshimoto Katsura

Research output: Contribution to journalArticlepeer-review

132 Citations (Scopus)

Abstract

The developmental potential of individual cells in the Lin-c-kit+CD45+IL-7R+ (IL-7R+) population from murine fetal liver was investigated using a clonal assay capable of determining the potential of a progenitor to give rise to myeloid, T, and B cells. Unipotent progenitors generating T cells (p-T) or B cells (p-B) but not other types of progenitors were found in the IL-7R+ population. A large proportion of progenitors at day 12 of gestation are p-T, whereas the frequency of p-T dramatically decreases with gestational age. In marked contrast, p-B are very rare by day 12, but they rapidly increase thereafter. These findings strongly suggest that the commitment of multipotent progenitors to T and B cell lineages occurs independently.

Original languageEnglish
Pages (from-to)441-450
Number of pages10
JournalImmunity
Volume12
Issue number4
DOIs
Publication statusPublished - 2000
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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