t(8;14)(q24;q32) in two patients with CD10-negative primary thyroid diffuse large B-cell lymphoma

Nozomi Niitsu; Masataka Okamoto; Tadashi Yoshino; Hirokazu Nakamine; Naoya Nakamura; Masami Bessho; Masami Hirano; Ikuo Miura

doi:10.1016/j.leukres.2006.06.014

t(8;14)(q24;q32) in two patients with CD10-negative primary thyroid diffuse large B-cell lymphoma

Nozomi Niitsu, Masataka Okamoto, Tadashi Yoshino, Hirokazu Nakamine, Naoya Nakamura, Masami Bessho, Masami Hirano, Ikuo Miura

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Diffuse large B-cell lymphoma (DLBCL) with the 8q24 translocation is occasionally seen in the gastrointestinal tract, but has rarely been reported in the thyroid gland. We experienced two cases of primary thyroid DLBCL having t(8;14)(q24;q32). The immunophenotype and karyotype of Case 1 (66-year-old female) and Case 2 (70-year-old female) were: CD10-, CD20+, BCL-2+/add(13)(q34), t(8;14)(q24;q32) and CD10-, CD20-, CD79a+, BCL-2-/t(8;14)(q24;q32), respectively. Although long-term complete remission could be achieved in both of our patients by conventional chemotherapy with/without radiation therapy, accumulation of further such cases is necessary to develop a standard treatment protocol and also to elucidate the pathogenesis of t(8;14)(q24;q32)-positive primary thyroid DLBCL.

Original language	English
Pages (from-to)	707-711
Number of pages	5
Journal	Leukemia Research
Volume	31
Issue number	5
DOIs	https://doi.org/10.1016/j.leukres.2006.06.014
Publication status	Published - 05-2007
Externally published	Yes

All Science Journal Classification (ASJC) codes

Hematology
Oncology
Cancer Research

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.leukres.2006.06.014

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title = "t(8;14)(q24;q32) in two patients with CD10-negative primary thyroid diffuse large B-cell lymphoma",

abstract = "Diffuse large B-cell lymphoma (DLBCL) with the 8q24 translocation is occasionally seen in the gastrointestinal tract, but has rarely been reported in the thyroid gland. We experienced two cases of primary thyroid DLBCL having t(8;14)(q24;q32). The immunophenotype and karyotype of Case 1 (66-year-old female) and Case 2 (70-year-old female) were: CD10-, CD20+, BCL-2+/add(13)(q34), t(8;14)(q24;q32) and CD10-, CD20-, CD79a+, BCL-2-/t(8;14)(q24;q32), respectively. Although long-term complete remission could be achieved in both of our patients by conventional chemotherapy with/without radiation therapy, accumulation of further such cases is necessary to develop a standard treatment protocol and also to elucidate the pathogenesis of t(8;14)(q24;q32)-positive primary thyroid DLBCL.",

author = "Nozomi Niitsu and Masataka Okamoto and Tadashi Yoshino and Hirokazu Nakamine and Naoya Nakamura and Masami Bessho and Masami Hirano and Ikuo Miura",

year = "2007",

month = may,

doi = "10.1016/j.leukres.2006.06.014",

language = "English",

volume = "31",

pages = "707--711",

journal = "Leukemia Research",

issn = "0145-2126",

publisher = "Elsevier Ltd",

number = "5",

}

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T1 - t(8;14)(q24;q32) in two patients with CD10-negative primary thyroid diffuse large B-cell lymphoma

AU - Niitsu, Nozomi

AU - Okamoto, Masataka

AU - Yoshino, Tadashi

AU - Nakamine, Hirokazu

AU - Nakamura, Naoya

AU - Bessho, Masami

AU - Hirano, Masami

AU - Miura, Ikuo

PY - 2007/5

Y1 - 2007/5

N2 - Diffuse large B-cell lymphoma (DLBCL) with the 8q24 translocation is occasionally seen in the gastrointestinal tract, but has rarely been reported in the thyroid gland. We experienced two cases of primary thyroid DLBCL having t(8;14)(q24;q32). The immunophenotype and karyotype of Case 1 (66-year-old female) and Case 2 (70-year-old female) were: CD10-, CD20+, BCL-2+/add(13)(q34), t(8;14)(q24;q32) and CD10-, CD20-, CD79a+, BCL-2-/t(8;14)(q24;q32), respectively. Although long-term complete remission could be achieved in both of our patients by conventional chemotherapy with/without radiation therapy, accumulation of further such cases is necessary to develop a standard treatment protocol and also to elucidate the pathogenesis of t(8;14)(q24;q32)-positive primary thyroid DLBCL.

AB - Diffuse large B-cell lymphoma (DLBCL) with the 8q24 translocation is occasionally seen in the gastrointestinal tract, but has rarely been reported in the thyroid gland. We experienced two cases of primary thyroid DLBCL having t(8;14)(q24;q32). The immunophenotype and karyotype of Case 1 (66-year-old female) and Case 2 (70-year-old female) were: CD10-, CD20+, BCL-2+/add(13)(q34), t(8;14)(q24;q32) and CD10-, CD20-, CD79a+, BCL-2-/t(8;14)(q24;q32), respectively. Although long-term complete remission could be achieved in both of our patients by conventional chemotherapy with/without radiation therapy, accumulation of further such cases is necessary to develop a standard treatment protocol and also to elucidate the pathogenesis of t(8;14)(q24;q32)-positive primary thyroid DLBCL.

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AN - SCOPUS:34147111267

SN - 0145-2126

VL - 31

SP - 707

EP - 711

JO - Leukemia Research

JF - Leukemia Research

IS - 5

ER -

t(8;14)(q24;q32) in two patients with CD10-negative primary thyroid diffuse large B-cell lymphoma

Abstract

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