Targeting the Hippo signalling pathway for cancer treatment

Keisuke Nakatani, Tomohiko Maehama, Miki Nishio, Hiroki Goto, Wakako Kato, Hirofumi Omori, Yosuke Miyachi, Hideru Togashi, Yohei Shimono, Akira Suzuki

Research output: Contribution to journalReview article

16 Citations (Scopus)

Abstract

The Hippo signalling pathway monitors cell-cell contact and external factors that shape tissue structure. In mice, tumourigenesis and developmental abnormalities are common consequences of dysregulated Hippo signalling. Expression of Hippo pathway components is also frequently altered in human tumours and correlates with poor prognosis and reduced patient survival. Thus, the Hippo pathway is an attractive anti-cancer target. Here, we provide an overview of the function and regulation of Hippo signalling components and summarize progress to date on the development of agents able to regulate Hippo signalling for cancer therapy.

Original languageEnglish
Pages (from-to)237-244
Number of pages8
JournalJournal of Biochemistry
Volume161
Issue number3
DOIs
Publication statusPublished - 2017

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology

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  • Cite this

    Nakatani, K., Maehama, T., Nishio, M., Goto, H., Kato, W., Omori, H., Miyachi, Y., Togashi, H., Shimono, Y., & Suzuki, A. (2017). Targeting the Hippo signalling pathway for cancer treatment. Journal of Biochemistry, 161(3), 237-244. https://doi.org/10.1093/jb/mvw074