Tau imaging detects distinctive distribution of tau pathology in ALS/PDC on the Kii Peninsula

Hitoshi Shinotoh, Hitoshi Shimada, Yasumasa Kokubo, Kenji Tagai, Fumitoshi Niwa, Soichiro Kitamura, Hironobu Endo, Maiko Ono, Yasuyuki Kimura, Shigeki Hirano, Maya Mimuro, Masanori Ichise, Naruhiko Sahara, Ming Rong Zhang, Tetsuya Suhara, Makoto Higuchi

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

To characterize the distribution of tau pathology in patients with amyotrophic lateral sclerosis/parkinsonism dementia complex on the Kii Peninsula (Kii ALS/PDC) by tau PET using [11C]PBB3 as ligand.MethodsThis is a cross-sectional study of 5 patients with ALS/PDC and one asymptomatic participant with a dense family history of ALS/PDC from the Kii Peninsula who took part in this study. All were men, and their age was 76 ± 8 (mean ± SD) years. Thirteen healthy men (69 ± 6 years) participated as healthy controls (HCs). Dynamic PET scans were performed following injection of [11C]PBB3, and parametric PET images were generated by voxel-by-voxel calculation of binding potential (BPND) using a multilinear reference tissue model. [11C] Pittsburgh compound B (PiB) PET, MRI, and cognitive tests were also performed.ResultsA voxel-based comparison of [11C]PBB3 BPND illustrated PET-detectable tau deposition in the cerebral cortex and white matter, and pontine basis including the corticospinal tract in Kii ALS/PDC patients compared with HCs (uncorrected p < 0.05). Group-wise volume of interest analysis of [11C]PBB3 BPND images showed increased BPND in the hippocampus and in frontal and parietal white matters of Kii ALS/PDC patients relative to HCs (p < 0.05, Holm-Sidak multiple comparisons test). BPND in frontal, temporal, and parietal gray matters correlated with Mini-Mental State Examination scores in Kii ALS/PDC patients (p < 0.05). All Kii ALS/PDC patients were negative for [11C]PiB (β-amyloid) except one with marginal positivity.Conclusion[11C]PBB3 PET visualized the characteristic topography of tau pathology in Kii ALS/PDC, corresponding to clinical phenotypes of this disease.

Original languageEnglish
Pages (from-to)E136-E147
JournalNeurology
Volume92
Issue number2
DOIs
Publication statusPublished - 08-01-2019
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Fingerprint

Dive into the research topics of 'Tau imaging detects distinctive distribution of tau pathology in ALS/PDC on the Kii Peninsula'. Together they form a unique fingerprint.

Cite this