Telomere Attrition and Elongation after Chronic Dialysis Initiation in Patients with End-Stage Renal Disease

Sawako Kato, Paul G. Shiels, Dagmara McGuinness, Bengt Lindholm, Peter Stenvinkel, Louise Nordfors, Abdul Rashid Qureshi, Yukio Yuzawa, Seiichi Matsuo, Shoichi Maruyama

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Aims: To analyze changes in telomere length (TL) after dialysis initiation. Methods: In 59 Japanese incident dialysis patients, associations between TL in peripheral blood leukocytes, inflammatory biomarkers and nutritional status at baseline and changes in TL during 1 year of dialysis, were investigated. Results: Whereas relative TL decreased by 8.6% (median 14.4%), TL elongation occurred in 16 patients (27%). Change in TL (ΔTL), defined as TL at 1 year minus TL at baseline, was associated with baseline TL (ρ = -0.70, p < 0.0001) and leukocyte count (ρ = 0.26, p = 0.044). In a logistic regression model, baseline TL (p < 0.0001) and leukocyte count (p = 0.047) were associated with ΔTL. Conclusions: TL shortening was observed in most incident dialysis patients. In 16 of the 59 patients, TL elongation occurred, possibly reflecting a more robust biological aging in patients whose naïve leukocytes may have undergone less proliferation to replace lost leukocytes.

Original languageEnglish
Pages (from-to)25-33
Number of pages9
JournalBlood Purification
Volume41
Issue number1-3
DOIs
Publication statusPublished - 01-03-2016

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Telomere
Chronic Kidney Failure
Dialysis
Leukocytes
Leukocyte Count
Logistic Models
Telomere Shortening
Nutritional Status
Biomarkers

All Science Journal Classification (ASJC) codes

  • Hematology
  • Nephrology

Cite this

Kato, S., Shiels, P. G., McGuinness, D., Lindholm, B., Stenvinkel, P., Nordfors, L., ... Maruyama, S. (2016). Telomere Attrition and Elongation after Chronic Dialysis Initiation in Patients with End-Stage Renal Disease. Blood Purification, 41(1-3), 25-33. https://doi.org/10.1159/000440971
Kato, Sawako ; Shiels, Paul G. ; McGuinness, Dagmara ; Lindholm, Bengt ; Stenvinkel, Peter ; Nordfors, Louise ; Qureshi, Abdul Rashid ; Yuzawa, Yukio ; Matsuo, Seiichi ; Maruyama, Shoichi. / Telomere Attrition and Elongation after Chronic Dialysis Initiation in Patients with End-Stage Renal Disease. In: Blood Purification. 2016 ; Vol. 41, No. 1-3. pp. 25-33.
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abstract = "Aims: To analyze changes in telomere length (TL) after dialysis initiation. Methods: In 59 Japanese incident dialysis patients, associations between TL in peripheral blood leukocytes, inflammatory biomarkers and nutritional status at baseline and changes in TL during 1 year of dialysis, were investigated. Results: Whereas relative TL decreased by 8.6{\%} (median 14.4{\%}), TL elongation occurred in 16 patients (27{\%}). Change in TL (ΔTL), defined as TL at 1 year minus TL at baseline, was associated with baseline TL (ρ = -0.70, p < 0.0001) and leukocyte count (ρ = 0.26, p = 0.044). In a logistic regression model, baseline TL (p < 0.0001) and leukocyte count (p = 0.047) were associated with ΔTL. Conclusions: TL shortening was observed in most incident dialysis patients. In 16 of the 59 patients, TL elongation occurred, possibly reflecting a more robust biological aging in patients whose na{\"i}ve leukocytes may have undergone less proliferation to replace lost leukocytes.",
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Kato, S, Shiels, PG, McGuinness, D, Lindholm, B, Stenvinkel, P, Nordfors, L, Qureshi, AR, Yuzawa, Y, Matsuo, S & Maruyama, S 2016, 'Telomere Attrition and Elongation after Chronic Dialysis Initiation in Patients with End-Stage Renal Disease', Blood Purification, vol. 41, no. 1-3, pp. 25-33. https://doi.org/10.1159/000440971

Telomere Attrition and Elongation after Chronic Dialysis Initiation in Patients with End-Stage Renal Disease. / Kato, Sawako; Shiels, Paul G.; McGuinness, Dagmara; Lindholm, Bengt; Stenvinkel, Peter; Nordfors, Louise; Qureshi, Abdul Rashid; Yuzawa, Yukio; Matsuo, Seiichi; Maruyama, Shoichi.

In: Blood Purification, Vol. 41, No. 1-3, 01.03.2016, p. 25-33.

Research output: Contribution to journalArticle

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AU - Kato, Sawako

AU - Shiels, Paul G.

AU - McGuinness, Dagmara

AU - Lindholm, Bengt

AU - Stenvinkel, Peter

AU - Nordfors, Louise

AU - Qureshi, Abdul Rashid

AU - Yuzawa, Yukio

AU - Matsuo, Seiichi

AU - Maruyama, Shoichi

PY - 2016/3/1

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N2 - Aims: To analyze changes in telomere length (TL) after dialysis initiation. Methods: In 59 Japanese incident dialysis patients, associations between TL in peripheral blood leukocytes, inflammatory biomarkers and nutritional status at baseline and changes in TL during 1 year of dialysis, were investigated. Results: Whereas relative TL decreased by 8.6% (median 14.4%), TL elongation occurred in 16 patients (27%). Change in TL (ΔTL), defined as TL at 1 year minus TL at baseline, was associated with baseline TL (ρ = -0.70, p < 0.0001) and leukocyte count (ρ = 0.26, p = 0.044). In a logistic regression model, baseline TL (p < 0.0001) and leukocyte count (p = 0.047) were associated with ΔTL. Conclusions: TL shortening was observed in most incident dialysis patients. In 16 of the 59 patients, TL elongation occurred, possibly reflecting a more robust biological aging in patients whose naïve leukocytes may have undergone less proliferation to replace lost leukocytes.

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Kato S, Shiels PG, McGuinness D, Lindholm B, Stenvinkel P, Nordfors L et al. Telomere Attrition and Elongation after Chronic Dialysis Initiation in Patients with End-Stage Renal Disease. Blood Purification. 2016 Mar 1;41(1-3):25-33. https://doi.org/10.1159/000440971