Telomere length as a potential biomarker of coronary artery disease

Joyeeta Bhattacharyya, Keichiro Mihara, Deborshi Bhattacharjee, Manjarí Mukherjee

Research output: Contribution to journalReview article

14 Citations (Scopus)

Abstract

Coronary artery disease (CAD) is a multifactorial disease whose prevalence remains unabated especially in developing countries. Both lifestyle factors and genetic predisposition contribute to this disorder. Though notable achievements have been made in the medical, interventional and surgical management of CAD, the need for its prevention is more important. Among other modalities, this calls for defining evidence-based new biomarkers, which on their own or in combination with other known biomarkers may predict the risk of CAD to enable institution of appropriate preventive strategies. In the present communication, we have discussed the usefulness of shortening of telomeres as a potential biomarker of CAD. Clinical research evidence in favour of telomere shortening in CAD is well documented in different ethnic populations of the world. Establishing a well-standardized and accurate method of evaluating telomere length is essential before its routine use in preventive cardiology.

Original languageEnglish
Pages (from-to)730-737
Number of pages8
JournalIndian Journal of Medical Research
Volume145
Issue numberJune
DOIs
Publication statusPublished - 06-2017

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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