TY - JOUR
T1 - Telomere length as a potential biomarker of coronary artery disease
AU - Bhattacharyya, Joyeeta
AU - Mihara, Keichiro
AU - Bhattacharjee, Deborshi
AU - Mukherjee, Manjarí
N1 - Funding Information:
Research at Cumballa Hill Hospital and Heart Institute is supported by the Department of Scientific and Industrial Research, Government of India.
PY - 2017/6
Y1 - 2017/6
N2 - Coronary artery disease (CAD) is a multifactorial disease whose prevalence remains unabated especially in developing countries. Both lifestyle factors and genetic predisposition contribute to this disorder. Though notable achievements have been made in the medical, interventional and surgical management of CAD, the need for its prevention is more important. Among other modalities, this calls for defining evidence-based new biomarkers, which on their own or in combination with other known biomarkers may predict the risk of CAD to enable institution of appropriate preventive strategies. In the present communication, we have discussed the usefulness of shortening of telomeres as a potential biomarker of CAD. Clinical research evidence in favour of telomere shortening in CAD is well documented in different ethnic populations of the world. Establishing a well-standardized and accurate method of evaluating telomere length is essential before its routine use in preventive cardiology.
AB - Coronary artery disease (CAD) is a multifactorial disease whose prevalence remains unabated especially in developing countries. Both lifestyle factors and genetic predisposition contribute to this disorder. Though notable achievements have been made in the medical, interventional and surgical management of CAD, the need for its prevention is more important. Among other modalities, this calls for defining evidence-based new biomarkers, which on their own or in combination with other known biomarkers may predict the risk of CAD to enable institution of appropriate preventive strategies. In the present communication, we have discussed the usefulness of shortening of telomeres as a potential biomarker of CAD. Clinical research evidence in favour of telomere shortening in CAD is well documented in different ethnic populations of the world. Establishing a well-standardized and accurate method of evaluating telomere length is essential before its routine use in preventive cardiology.
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U2 - 10.4103/0971-5916.216974
DO - 10.4103/0971-5916.216974
M3 - Review article
C2 - 29067974
AN - SCOPUS:85033683976
VL - 145
SP - 730
EP - 737
JO - Indian Journal of Medical Research
JF - Indian Journal of Medical Research
SN - 0971-5916
IS - June
ER -