Telomere length in leukocyte DNA in gastric cancer patients and its association with clinicopathological features and prognosis

Tomomitsu Tahara; Sayumi Tahara; Noriyuki Horiguchi; Tomohiko Kawamura; Masaaki Okubo; Takamitsu Ishizuka; Hyuga Yamada; Dai Yoshida; Takafumi Ohmori; Kohei Maedanaruomi Komura; Hirokazu Ikuno; Yasutaka Jodai; Toshiaki Kamano; Mitsuo Nagasaka; Yoshihito Nakagawa; Tetsuya Tuskamoto; Makoto Urano; Tomoyuki Shibata; Makoto Kuroda; Naoki Ohmiya

doi:10.21873/anticanres.11543

Telomere length in leukocyte DNA in gastric cancer patients and its association with clinicopathological features and prognosis

Tomomitsu Tahara, Sayumi Tahara, Noriyuki Horiguchi, Tomohiko Kawamura, Masaaki Okubo, Takamitsu Ishizuka, Hyuga Yamada, Dai Yoshida, Takafumi Ohmori, Kohei Maedanaruomi Komura, Hirokazu Ikuno, Yasutaka Jodai, Toshiaki Kamano, Mitsuo Nagasaka, Yoshihito Nakagawa, Tetsuya Tuskamoto, Makoto Urano, Tomoyuki Shibata, Makoto Kuroda, Naoki Ohmiya

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Background/Aim: Telomere shortening in leukocytes has been thought to be associated with reduced immuneresponse capacity and increased chromosome instability. Several studies indicate that telomere length in the peripheral blood leukocyte DNA can predict clinical outcome of several cancers. We evaluated the potential association between telomere shortening in the leukocyte DNA and clinicopathological features and prognosis of gastric cancer (GC) in Japanese patients. Materials and Methods: Telomere length in leukocyte DNA was measured using quantitative real-time polymerase chain reaction (PCR) in 207 GC patients. The association between telomere length and clinicopathological features and prognosis was evaluated. Results: These short-telomere group was significantly associated with advanced stage (p=0.015), worse overall survival (OS) and progression-free survival (PFS) (p=0.046 and 0.026, respectively). The same group was also weakly associated with overall and peritoneal recurrences (p=0.052 and 0.059, respectively). Conclusion: Telomere shortening in leukocyte DNA is associated with advanced stage and poor prognosis of GC, which may reflect their reduced immune response capacity or increased chromosome instability.

Original language	English
Pages (from-to)	1997-2001
Number of pages	5
Journal	Anticancer research
Volume	37
Issue number	4
DOIs	https://doi.org/10.21873/anticanres.11543
Publication status	Published - 04-2017

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.21873/anticanres.11543

Cite this

Tahara, T., Tahara, S., Horiguchi, N., Kawamura, T., Okubo, M., Ishizuka, T., Yamada, H., Yoshida, D., Ohmori, T., Komura, K. M., Ikuno, H., Jodai, Y., Kamano, T., Nagasaka, M., Nakagawa, Y., Tuskamoto, T., Urano, M., Shibata, T., Kuroda, M., & Ohmiya, N. (2017). Telomere length in leukocyte DNA in gastric cancer patients and its association with clinicopathological features and prognosis. Anticancer research, 37(4), 1997-2001. https://doi.org/10.21873/anticanres.11543

@article{f64e7700e4e94dc0835c84c193582637,

title = "Telomere length in leukocyte DNA in gastric cancer patients and its association with clinicopathological features and prognosis",

abstract = "Background/Aim: Telomere shortening in leukocytes has been thought to be associated with reduced immuneresponse capacity and increased chromosome instability. Several studies indicate that telomere length in the peripheral blood leukocyte DNA can predict clinical outcome of several cancers. We evaluated the potential association between telomere shortening in the leukocyte DNA and clinicopathological features and prognosis of gastric cancer (GC) in Japanese patients. Materials and Methods: Telomere length in leukocyte DNA was measured using quantitative real-time polymerase chain reaction (PCR) in 207 GC patients. The association between telomere length and clinicopathological features and prognosis was evaluated. Results: These short-telomere group was significantly associated with advanced stage (p=0.015), worse overall survival (OS) and progression-free survival (PFS) (p=0.046 and 0.026, respectively). The same group was also weakly associated with overall and peritoneal recurrences (p=0.052 and 0.059, respectively). Conclusion: Telomere shortening in leukocyte DNA is associated with advanced stage and poor prognosis of GC, which may reflect their reduced immune response capacity or increased chromosome instability.",

keywords = "Gastric cancer, Japanese, Leukocyte DNA, Prognosis, Telomere shortening",

author = "Tomomitsu Tahara and Sayumi Tahara and Noriyuki Horiguchi and Tomohiko Kawamura and Masaaki Okubo and Takamitsu Ishizuka and Hyuga Yamada and Dai Yoshida and Takafumi Ohmori and Komura, {Kohei Maedanaruomi} and Hirokazu Ikuno and Yasutaka Jodai and Toshiaki Kamano and Mitsuo Nagasaka and Yoshihito Nakagawa and Tetsuya Tuskamoto and Makoto Urano and Tomoyuki Shibata and Makoto Kuroda and Naoki Ohmiya",

year = "2017",

month = apr,

doi = "10.21873/anticanres.11543",

language = "English",

volume = "37",

pages = "1997--2001",

journal = "Anticancer research",

issn = "0250-7005",

publisher = "International Institute of Anticancer Research",

number = "4",

}

Tahara, T, Tahara, S, Horiguchi, N, Kawamura, T, Okubo, M, Ishizuka, T, Yamada, H , Yoshida, D , Ohmori, T, Komura, KM, Ikuno, H, Jodai, Y, Kamano, T , Nagasaka, M, Nakagawa, Y, Tuskamoto, T, Urano, M , Shibata, T, Kuroda, M & Ohmiya, N 2017, 'Telomere length in leukocyte DNA in gastric cancer patients and its association with clinicopathological features and prognosis', Anticancer research, vol. 37, no. 4, pp. 1997-2001. https://doi.org/10.21873/anticanres.11543

TY - JOUR

T1 - Telomere length in leukocyte DNA in gastric cancer patients and its association with clinicopathological features and prognosis

AU - Tahara, Tomomitsu

AU - Tahara, Sayumi

AU - Horiguchi, Noriyuki

AU - Kawamura, Tomohiko

AU - Okubo, Masaaki

AU - Ishizuka, Takamitsu

AU - Yamada, Hyuga

AU - Yoshida, Dai

AU - Ohmori, Takafumi

AU - Komura, Kohei Maedanaruomi

AU - Ikuno, Hirokazu

AU - Jodai, Yasutaka

AU - Kamano, Toshiaki

AU - Nagasaka, Mitsuo

AU - Nakagawa, Yoshihito

AU - Tuskamoto, Tetsuya

AU - Urano, Makoto

AU - Shibata, Tomoyuki

AU - Kuroda, Makoto

AU - Ohmiya, Naoki

PY - 2017/4

Y1 - 2017/4

N2 - Background/Aim: Telomere shortening in leukocytes has been thought to be associated with reduced immuneresponse capacity and increased chromosome instability. Several studies indicate that telomere length in the peripheral blood leukocyte DNA can predict clinical outcome of several cancers. We evaluated the potential association between telomere shortening in the leukocyte DNA and clinicopathological features and prognosis of gastric cancer (GC) in Japanese patients. Materials and Methods: Telomere length in leukocyte DNA was measured using quantitative real-time polymerase chain reaction (PCR) in 207 GC patients. The association between telomere length and clinicopathological features and prognosis was evaluated. Results: These short-telomere group was significantly associated with advanced stage (p=0.015), worse overall survival (OS) and progression-free survival (PFS) (p=0.046 and 0.026, respectively). The same group was also weakly associated with overall and peritoneal recurrences (p=0.052 and 0.059, respectively). Conclusion: Telomere shortening in leukocyte DNA is associated with advanced stage and poor prognosis of GC, which may reflect their reduced immune response capacity or increased chromosome instability.

AB - Background/Aim: Telomere shortening in leukocytes has been thought to be associated with reduced immuneresponse capacity and increased chromosome instability. Several studies indicate that telomere length in the peripheral blood leukocyte DNA can predict clinical outcome of several cancers. We evaluated the potential association between telomere shortening in the leukocyte DNA and clinicopathological features and prognosis of gastric cancer (GC) in Japanese patients. Materials and Methods: Telomere length in leukocyte DNA was measured using quantitative real-time polymerase chain reaction (PCR) in 207 GC patients. The association between telomere length and clinicopathological features and prognosis was evaluated. Results: These short-telomere group was significantly associated with advanced stage (p=0.015), worse overall survival (OS) and progression-free survival (PFS) (p=0.046 and 0.026, respectively). The same group was also weakly associated with overall and peritoneal recurrences (p=0.052 and 0.059, respectively). Conclusion: Telomere shortening in leukocyte DNA is associated with advanced stage and poor prognosis of GC, which may reflect their reduced immune response capacity or increased chromosome instability.

KW - Gastric cancer

KW - Japanese

KW - Leukocyte DNA

KW - Prognosis

KW - Telomere shortening

UR - http://www.scopus.com/inward/record.url?scp=85017417243&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85017417243&partnerID=8YFLogxK

U2 - 10.21873/anticanres.11543

DO - 10.21873/anticanres.11543

M3 - Article

C2 - 28373473

AN - SCOPUS:85017417243

SN - 0250-7005

VL - 37

SP - 1997

EP - 2001

JO - Anticancer research

JF - Anticancer research

IS - 4

ER -

Telomere length in leukocyte DNA in gastric cancer patients and its association with clinicopathological features and prognosis

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this