Telomere length in leukocyte DNA in gastric cancer patients and its association with clinicopathological features and prognosis

Tomomitsu Tahara, Sayumi Tahara, Noriyuki Horiguchi, Tomohiko Kawamura, Masaaki Okubo, Takamitsu Ishizuka, Hyuga Yamada, Dai Yoshida, Takafumi Ohmori, Kohei Maedanaruomi Komura, Hirokazu Ikuno, Yasutaka Jodai, Toshiaki Kamano, Mitsuo Nagasaka, Yoshihito Nakagawa, Tetsuya Tuskamoto, Makoto Urano, Tomoyuki Shibata, Makoto Kuroda, Naoki Omiya

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background/Aim: Telomere shortening in leukocytes has been thought to be associated with reduced immuneresponse capacity and increased chromosome instability. Several studies indicate that telomere length in the peripheral blood leukocyte DNA can predict clinical outcome of several cancers. We evaluated the potential association between telomere shortening in the leukocyte DNA and clinicopathological features and prognosis of gastric cancer (GC) in Japanese patients. Materials and Methods: Telomere length in leukocyte DNA was measured using quantitative real-time polymerase chain reaction (PCR) in 207 GC patients. The association between telomere length and clinicopathological features and prognosis was evaluated. Results: These short-telomere group was significantly associated with advanced stage (p=0.015), worse overall survival (OS) and progression-free survival (PFS) (p=0.046 and 0.026, respectively). The same group was also weakly associated with overall and peritoneal recurrences (p=0.052 and 0.059, respectively). Conclusion: Telomere shortening in leukocyte DNA is associated with advanced stage and poor prognosis of GC, which may reflect their reduced immune response capacity or increased chromosome instability.

Original languageEnglish
Pages (from-to)1997-2001
Number of pages5
JournalAnticancer research
Volume37
Issue number4
DOIs
Publication statusPublished - 01-04-2017

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Telomere
Stomach Neoplasms
Telomere Shortening
Leukocytes
DNA
Chromosomal Instability
Disease-Free Survival
Real-Time Polymerase Chain Reaction
Recurrence
Survival
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Tahara, Tomomitsu ; Tahara, Sayumi ; Horiguchi, Noriyuki ; Kawamura, Tomohiko ; Okubo, Masaaki ; Ishizuka, Takamitsu ; Yamada, Hyuga ; Yoshida, Dai ; Ohmori, Takafumi ; Komura, Kohei Maedanaruomi ; Ikuno, Hirokazu ; Jodai, Yasutaka ; Kamano, Toshiaki ; Nagasaka, Mitsuo ; Nakagawa, Yoshihito ; Tuskamoto, Tetsuya ; Urano, Makoto ; Shibata, Tomoyuki ; Kuroda, Makoto ; Omiya, Naoki. / Telomere length in leukocyte DNA in gastric cancer patients and its association with clinicopathological features and prognosis. In: Anticancer research. 2017 ; Vol. 37, No. 4. pp. 1997-2001.
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abstract = "Background/Aim: Telomere shortening in leukocytes has been thought to be associated with reduced immuneresponse capacity and increased chromosome instability. Several studies indicate that telomere length in the peripheral blood leukocyte DNA can predict clinical outcome of several cancers. We evaluated the potential association between telomere shortening in the leukocyte DNA and clinicopathological features and prognosis of gastric cancer (GC) in Japanese patients. Materials and Methods: Telomere length in leukocyte DNA was measured using quantitative real-time polymerase chain reaction (PCR) in 207 GC patients. The association between telomere length and clinicopathological features and prognosis was evaluated. Results: These short-telomere group was significantly associated with advanced stage (p=0.015), worse overall survival (OS) and progression-free survival (PFS) (p=0.046 and 0.026, respectively). The same group was also weakly associated with overall and peritoneal recurrences (p=0.052 and 0.059, respectively). Conclusion: Telomere shortening in leukocyte DNA is associated with advanced stage and poor prognosis of GC, which may reflect their reduced immune response capacity or increased chromosome instability.",
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Tahara, T, Tahara, S, Horiguchi, N, Kawamura, T, Okubo, M, Ishizuka, T, Yamada, H, Yoshida, D, Ohmori, T, Komura, KM, Ikuno, H, Jodai, Y, Kamano, T, Nagasaka, M, Nakagawa, Y, Tuskamoto, T, Urano, M, Shibata, T, Kuroda, M & Omiya, N 2017, 'Telomere length in leukocyte DNA in gastric cancer patients and its association with clinicopathological features and prognosis', Anticancer research, vol. 37, no. 4, pp. 1997-2001. https://doi.org/10.21873/anticanres.11543

Telomere length in leukocyte DNA in gastric cancer patients and its association with clinicopathological features and prognosis. / Tahara, Tomomitsu; Tahara, Sayumi; Horiguchi, Noriyuki; Kawamura, Tomohiko; Okubo, Masaaki; Ishizuka, Takamitsu; Yamada, Hyuga; Yoshida, Dai; Ohmori, Takafumi; Komura, Kohei Maedanaruomi; Ikuno, Hirokazu; Jodai, Yasutaka; Kamano, Toshiaki; Nagasaka, Mitsuo; Nakagawa, Yoshihito; Tuskamoto, Tetsuya; Urano, Makoto; Shibata, Tomoyuki; Kuroda, Makoto; Omiya, Naoki.

In: Anticancer research, Vol. 37, No. 4, 01.04.2017, p. 1997-2001.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Telomere length in leukocyte DNA in gastric cancer patients and its association with clinicopathological features and prognosis

AU - Tahara, Tomomitsu

AU - Tahara, Sayumi

AU - Horiguchi, Noriyuki

AU - Kawamura, Tomohiko

AU - Okubo, Masaaki

AU - Ishizuka, Takamitsu

AU - Yamada, Hyuga

AU - Yoshida, Dai

AU - Ohmori, Takafumi

AU - Komura, Kohei Maedanaruomi

AU - Ikuno, Hirokazu

AU - Jodai, Yasutaka

AU - Kamano, Toshiaki

AU - Nagasaka, Mitsuo

AU - Nakagawa, Yoshihito

AU - Tuskamoto, Tetsuya

AU - Urano, Makoto

AU - Shibata, Tomoyuki

AU - Kuroda, Makoto

AU - Omiya, Naoki

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Background/Aim: Telomere shortening in leukocytes has been thought to be associated with reduced immuneresponse capacity and increased chromosome instability. Several studies indicate that telomere length in the peripheral blood leukocyte DNA can predict clinical outcome of several cancers. We evaluated the potential association between telomere shortening in the leukocyte DNA and clinicopathological features and prognosis of gastric cancer (GC) in Japanese patients. Materials and Methods: Telomere length in leukocyte DNA was measured using quantitative real-time polymerase chain reaction (PCR) in 207 GC patients. The association between telomere length and clinicopathological features and prognosis was evaluated. Results: These short-telomere group was significantly associated with advanced stage (p=0.015), worse overall survival (OS) and progression-free survival (PFS) (p=0.046 and 0.026, respectively). The same group was also weakly associated with overall and peritoneal recurrences (p=0.052 and 0.059, respectively). Conclusion: Telomere shortening in leukocyte DNA is associated with advanced stage and poor prognosis of GC, which may reflect their reduced immune response capacity or increased chromosome instability.

AB - Background/Aim: Telomere shortening in leukocytes has been thought to be associated with reduced immuneresponse capacity and increased chromosome instability. Several studies indicate that telomere length in the peripheral blood leukocyte DNA can predict clinical outcome of several cancers. We evaluated the potential association between telomere shortening in the leukocyte DNA and clinicopathological features and prognosis of gastric cancer (GC) in Japanese patients. Materials and Methods: Telomere length in leukocyte DNA was measured using quantitative real-time polymerase chain reaction (PCR) in 207 GC patients. The association between telomere length and clinicopathological features and prognosis was evaluated. Results: These short-telomere group was significantly associated with advanced stage (p=0.015), worse overall survival (OS) and progression-free survival (PFS) (p=0.046 and 0.026, respectively). The same group was also weakly associated with overall and peritoneal recurrences (p=0.052 and 0.059, respectively). Conclusion: Telomere shortening in leukocyte DNA is associated with advanced stage and poor prognosis of GC, which may reflect their reduced immune response capacity or increased chromosome instability.

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