TY - JOUR
T1 - Temperature-Sensitive Growth Mutants as Live Vaccines against Experimental Murine Salmonellosis
AU - Ohta, Michio
AU - Kido, Nobuo
AU - Fujii, Yasuaki
AU - Arakawa, Yoshichika
AU - Komatsu, Takayuki
AU - Kato, Nobuo
PY - 1987
Y1 - 1987
N2 - Temperature-sensitive growth mutants of Salmonella enteritidis, NUB 209 and NUB 323, characterized as protein synthesis mutants, were unable to pro-liferate at 37 C and lost the parent's virulence. In mice, these mutants conferred high levels of protection as live vaccines. Although the vaccination effect of NUB 323 was not so good as that of NUB 209, NUB 323 was preferred as a safer live vaccine because this mutant was completely avirulent and no back mutation appeared.
AB - Temperature-sensitive growth mutants of Salmonella enteritidis, NUB 209 and NUB 323, characterized as protein synthesis mutants, were unable to pro-liferate at 37 C and lost the parent's virulence. In mice, these mutants conferred high levels of protection as live vaccines. Although the vaccination effect of NUB 323 was not so good as that of NUB 209, NUB 323 was preferred as a safer live vaccine because this mutant was completely avirulent and no back mutation appeared.
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U2 - 10.1111/j.1348-0421.1987.tb01359.x
DO - 10.1111/j.1348-0421.1987.tb01359.x
M3 - Article
C2 - 3330174
AN - SCOPUS:0023605886
SN - 0385-5600
VL - 31
SP - 1259
EP - 1265
JO - MICROBIOLOGY and IMMUNOLOGY
JF - MICROBIOLOGY and IMMUNOLOGY
IS - 12
ER -
