Tenascin takes part in the progress of pathological severity in cerebral falciparum infection

Yoshimasa Maeno, Shusuke Nakazawa, Yasuhiro Kusuhara, Moriaki Kusakabe, Keizo Nagase, Hiroji Kanbara, Masamichi Aikawa, Toshio Nakabayashi

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Abstract

We examined plasma level of circulating form of tenascin (TC) in falciparum malaria patients, cerebral malaria and non cerebral malaria, and compared them to uninfected healthy persons. Plasma level of TC examined were significantly higher in malaria patients than in control persons (p< 0.01). The results also show that among malaria patients, TC level was higher in the cerebral malaria patients compare to non cerebral malaria patients (p<0.10). Kinetics of TC level in plasma were related to kinetics of TNF-α level. Moreover, patients with higher level of TC showed higher level of parasitized erythrocytes binding ratio. Immunohistochemical study showed that TC was found in the cerebral microvessels of postmortem cerebral tissues from nine cerebral malaria cases. These results provide evidence that plasma level of TC correlates with the severity in cerebral malaria patients.

Original languageEnglish
Pages (from-to)267-269
Number of pages3
JournalTokai Journal of Experimental and Clinical Medicine
Volume23
Issue number6
Publication statusPublished - 01-12-1998

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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    Maeno, Y., Nakazawa, S., Kusuhara, Y., Kusakabe, M., Nagase, K., Kanbara, H., Aikawa, M., & Nakabayashi, T. (1998). Tenascin takes part in the progress of pathological severity in cerebral falciparum infection. Tokai Journal of Experimental and Clinical Medicine, 23(6), 267-269.