Thalidomide increases both REM and stage 3-4 sleep in human adults: A preliminary study

Takashi Kanbayashi; Tetsuo Shimizu; Yuji Takahashi; Tsuyoshi Kitajima; Ken Ichi Takahashi; Yasushi Saito; Yasuo Hishikawa

doi:10.1093/sleep/22.1.113

Thalidomide increases both REM and stage 3-4 sleep in human adults: A preliminary study

Takashi Kanbayashi, Tetsuo Shimizu, Yuji Takahashi, Tsuyoshi Kitajima, Ken Ichi Takahashi, Yasushi Saito, Yasuo Hishikawa

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

Polysomnography was used to assess the effect of thalidomide on human sleep. This compound significantly increased the time spent in REM and stage 3-4 sleep as compared with placebo. On the other hand, thalidomide significantly decreased the time spent in stage 1, while the time spent in stage 2 was unchanged. The effect of thalidomide on REM and stage 3-4 sleep is unique as compared with other hypnotics. Although the mode of action of this compound is unknown, further studies on thalidomide should help in our understanding of the mechanisms of sleep regulation.

Original language	English
Pages (from-to)	113-115
Number of pages	3
Journal	Sleep
Volume	22
Issue number	1
DOIs	https://doi.org/10.1093/sleep/22.1.113
Publication status	Published - 01-02-1999
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Medicine

Access to Document

10.1093/sleep/22.1.113

Cite this

@article{7e1d9c48f4de407685ee9c4d09eaab89,

title = "Thalidomide increases both REM and stage 3-4 sleep in human adults: A preliminary study",

abstract = "Polysomnography was used to assess the effect of thalidomide on human sleep. This compound significantly increased the time spent in REM and stage 3-4 sleep as compared with placebo. On the other hand, thalidomide significantly decreased the time spent in stage 1, while the time spent in stage 2 was unchanged. The effect of thalidomide on REM and stage 3-4 sleep is unique as compared with other hypnotics. Although the mode of action of this compound is unknown, further studies on thalidomide should help in our understanding of the mechanisms of sleep regulation.",

author = "Takashi Kanbayashi and Tetsuo Shimizu and Yuji Takahashi and Tsuyoshi Kitajima and Takahashi, {Ken Ichi} and Yasushi Saito and Yasuo Hishikawa",

year = "1999",

month = feb,

day = "1",

doi = "10.1093/sleep/22.1.113",

language = "English",

volume = "22",

pages = "113--115",

journal = "Sleep",

issn = "0161-8105",

publisher = "Oxford University Press",

number = "1",

}

TY - JOUR

T1 - Thalidomide increases both REM and stage 3-4 sleep in human adults

T2 - A preliminary study

AU - Kanbayashi, Takashi

AU - Shimizu, Tetsuo

AU - Takahashi, Yuji

AU - Kitajima, Tsuyoshi

AU - Takahashi, Ken Ichi

AU - Saito, Yasushi

AU - Hishikawa, Yasuo

PY - 1999/2/1

Y1 - 1999/2/1

N2 - Polysomnography was used to assess the effect of thalidomide on human sleep. This compound significantly increased the time spent in REM and stage 3-4 sleep as compared with placebo. On the other hand, thalidomide significantly decreased the time spent in stage 1, while the time spent in stage 2 was unchanged. The effect of thalidomide on REM and stage 3-4 sleep is unique as compared with other hypnotics. Although the mode of action of this compound is unknown, further studies on thalidomide should help in our understanding of the mechanisms of sleep regulation.

AB - Polysomnography was used to assess the effect of thalidomide on human sleep. This compound significantly increased the time spent in REM and stage 3-4 sleep as compared with placebo. On the other hand, thalidomide significantly decreased the time spent in stage 1, while the time spent in stage 2 was unchanged. The effect of thalidomide on REM and stage 3-4 sleep is unique as compared with other hypnotics. Although the mode of action of this compound is unknown, further studies on thalidomide should help in our understanding of the mechanisms of sleep regulation.

UR - http://www.scopus.com/inward/record.url?scp=0033082365&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033082365&partnerID=8YFLogxK

U2 - 10.1093/sleep/22.1.113

DO - 10.1093/sleep/22.1.113

M3 - Article

C2 - 9989372

AN - SCOPUS:0033082365

SN - 0161-8105

VL - 22

SP - 113

EP - 115

JO - Sleep

JF - Sleep

IS - 1

ER -

Thalidomide increases both REM and stage 3-4 sleep in human adults: A preliminary study

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this