Thalidomide increases both REM and stage 3-4 sleep in human adults

A preliminary study

Takashi Kanbayashi, Tetsuo Shimizu, Yuji Takahashi, Tsuyoshi Kitajima, Ken Ichi Takahashi, Yasushi Saito, Yasuo Hishikawa

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Polysomnography was used to assess the effect of thalidomide on human sleep. This compound significantly increased the time spent in REM and stage 3-4 sleep as compared with placebo. On the other hand, thalidomide significantly decreased the time spent in stage 1, while the time spent in stage 2 was unchanged. The effect of thalidomide on REM and stage 3-4 sleep is unique as compared with other hypnotics. Although the mode of action of this compound is unknown, further studies on thalidomide should help in our understanding of the mechanisms of sleep regulation.

Original languageEnglish
Pages (from-to)113-115
Number of pages3
JournalSleep
Volume22
Issue number1
DOIs
Publication statusPublished - 01-02-1999

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Thalidomide
Sleep
Polysomnography
Hypnotics and Sedatives
Placebos

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Physiology (medical)

Cite this

Kanbayashi, T., Shimizu, T., Takahashi, Y., Kitajima, T., Takahashi, K. I., Saito, Y., & Hishikawa, Y. (1999). Thalidomide increases both REM and stage 3-4 sleep in human adults: A preliminary study. Sleep, 22(1), 113-115. https://doi.org/10.1093/sleep/22.1.113
Kanbayashi, Takashi ; Shimizu, Tetsuo ; Takahashi, Yuji ; Kitajima, Tsuyoshi ; Takahashi, Ken Ichi ; Saito, Yasushi ; Hishikawa, Yasuo. / Thalidomide increases both REM and stage 3-4 sleep in human adults : A preliminary study. In: Sleep. 1999 ; Vol. 22, No. 1. pp. 113-115.
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Kanbayashi, T, Shimizu, T, Takahashi, Y, Kitajima, T, Takahashi, KI, Saito, Y & Hishikawa, Y 1999, 'Thalidomide increases both REM and stage 3-4 sleep in human adults: A preliminary study', Sleep, vol. 22, no. 1, pp. 113-115. https://doi.org/10.1093/sleep/22.1.113

Thalidomide increases both REM and stage 3-4 sleep in human adults : A preliminary study. / Kanbayashi, Takashi; Shimizu, Tetsuo; Takahashi, Yuji; Kitajima, Tsuyoshi; Takahashi, Ken Ichi; Saito, Yasushi; Hishikawa, Yasuo.

In: Sleep, Vol. 22, No. 1, 01.02.1999, p. 113-115.

Research output: Contribution to journalArticle

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Kanbayashi T, Shimizu T, Takahashi Y, Kitajima T, Takahashi KI, Saito Y et al. Thalidomide increases both REM and stage 3-4 sleep in human adults: A preliminary study. Sleep. 1999 Feb 1;22(1):113-115. https://doi.org/10.1093/sleep/22.1.113