The 2′,3′-cyclic nucleotide 3′-phosphodiesterase and oligodendrocyte lineage transcription factor 2 genes do not appear to be associated with schizophrenia in the Japanese population

Hinako Usui, Nagahide Takahashi, Shinichi Saito, Ryoko Ishihara, Nagisa Aoyama, Masashi Ikeda, Tatsuyo Suzuki, Tsuyoshi Kitajima, Yoshio Yamanouchi, Yoko Kinoshita, Keizo Yoshida, Nakao Iwata, Toshiya Inada, Norio Ozaki

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Abstract

Several lines of evidence suggest that disturbance of myelin-related genes is associated with the etiology of schizophrenia. Recently, the 2′,3′-cyclic nucleotide 3′-phosphodiesterase (CNP) gene and the oligodendrocyte lineage transcription factor 2 (OLIG2) gene were reported to be related to the development of schizophrenia, based on the results of genetic association and microarray studies. In the present study, no significant association with schizophrenia was observed by single-marker or haplotype analysis for 6 tag SNPs of these genes (759 cases, 757 controls). These findings suggest that CNP and OLIG2 are unlikely to be related to the development of schizophrenia in the Japanese population.

Original languageEnglish
Pages (from-to)245-250
Number of pages6
JournalSchizophrenia Research
Volume88
Issue number1-3
DOIs
Publication statusPublished - 01-12-2006

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All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Biological Psychiatry

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