The 2′,3′-cyclic nucleotide 3′-phosphodiesterase and oligodendrocyte lineage transcription factor 2 genes do not appear to be associated with schizophrenia in the Japanese population

Hinako Usui; Nagahide Takahashi; Shinichi Saito; Ryoko Ishihara; Nagisa Aoyama; Masashi Ikeda; Tatsuyo Suzuki; Tsuyoshi Kitajima; Yoshio Yamanouchi; Yoko Kinoshita; Keizo Yoshida; Nakao Iwata; Toshiya Inada; Norio Ozaki

doi:10.1016/j.schres.2006.07.019

The 2′,3′-cyclic nucleotide 3′-phosphodiesterase and oligodendrocyte lineage transcription factor 2 genes do not appear to be associated with schizophrenia in the Japanese population

Hinako Usui
, Nagahide Takahashi
, Shinichi Saito
, Ryoko Ishihara
, Nagisa Aoyama
, Masashi Ikeda
, Tatsuyo Suzuki
, Tsuyoshi Kitajima
, Yoshio Yamanouchi
, Yoko Kinoshita
, Keizo Yoshida
, Nakao Iwata
, Toshiya Inada
, Norio Ozaki

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Several lines of evidence suggest that disturbance of myelin-related genes is associated with the etiology of schizophrenia. Recently, the 2′,3′-cyclic nucleotide 3′-phosphodiesterase (CNP) gene and the oligodendrocyte lineage transcription factor 2 (OLIG2) gene were reported to be related to the development of schizophrenia, based on the results of genetic association and microarray studies. In the present study, no significant association with schizophrenia was observed by single-marker or haplotype analysis for 6 tag SNPs of these genes (759 cases, 757 controls). These findings suggest that CNP and OLIG2 are unlikely to be related to the development of schizophrenia in the Japanese population.

Original language	English
Pages (from-to)	245-250
Number of pages	6
Journal	Schizophrenia Research
Volume	88
Issue number	1-3
DOIs	https://doi.org/10.1016/j.schres.2006.07.019
Publication status	Published - 12-2006

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Psychiatry and Mental health
Biological Psychiatry

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10.1016/j.schres.2006.07.019

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Usui, H., Takahashi, N., Saito, S., Ishihara, R., Aoyama, N., Ikeda, M., Suzuki, T., Kitajima, T., Yamanouchi, Y., Kinoshita, Y., Yoshida, K., Iwata, N., Inada, T., & Ozaki, N. (2006). The 2′,3′-cyclic nucleotide 3′-phosphodiesterase and oligodendrocyte lineage transcription factor 2 genes do not appear to be associated with schizophrenia in the Japanese population. Schizophrenia Research, 88(1-3), 245-250. https://doi.org/10.1016/j.schres.2006.07.019

@article{9e9d3a41ea7c4a7dbee076d8b75e563c,

title = "The 2′,3′-cyclic nucleotide 3′-phosphodiesterase and oligodendrocyte lineage transcription factor 2 genes do not appear to be associated with schizophrenia in the Japanese population",

abstract = "Several lines of evidence suggest that disturbance of myelin-related genes is associated with the etiology of schizophrenia. Recently, the 2′,3′-cyclic nucleotide 3′-phosphodiesterase (CNP) gene and the oligodendrocyte lineage transcription factor 2 (OLIG2) gene were reported to be related to the development of schizophrenia, based on the results of genetic association and microarray studies. In the present study, no significant association with schizophrenia was observed by single-marker or haplotype analysis for 6 tag SNPs of these genes (759 cases, 757 controls). These findings suggest that CNP and OLIG2 are unlikely to be related to the development of schizophrenia in the Japanese population.",

keywords = "CNP, Haplotypes, Linkage disequilibrium, OLIG2, Schizophrenia",

author = "Hinako Usui and Nagahide Takahashi and Shinichi Saito and Ryoko Ishihara and Nagisa Aoyama and Masashi Ikeda and Tatsuyo Suzuki and Tsuyoshi Kitajima and Yoshio Yamanouchi and Yoko Kinoshita and Keizo Yoshida and Nakao Iwata and Toshiya Inada and Norio Ozaki",

note = "Funding Information: We thank Y. Nakamura for the technical support. This work was supported in part by research grants from the Ministry of Education, Culture, Sports, Science, and Technology of Japan, the Ministry of Health, Labor, and Welfare of Japan, and the Japan Health Sciences Foundation (Research on Health Sciences Focusing on Drug Innovation).",

year = "2006",

month = dec,

doi = "10.1016/j.schres.2006.07.019",

language = "English",

volume = "88",

pages = "245--250",

journal = "Schizophrenia Research",

issn = "0920-9964",

publisher = "Elsevier B.V.",

number = "1-3",

}

Usui, H, Takahashi, N, Saito, S, Ishihara, R, Aoyama, N, Ikeda, M, Suzuki, T, Kitajima, T, Yamanouchi, Y, Kinoshita, Y, Yoshida, K, Iwata, N, Inada, T & Ozaki, N 2006, 'The 2′,3′-cyclic nucleotide 3′-phosphodiesterase and oligodendrocyte lineage transcription factor 2 genes do not appear to be associated with schizophrenia in the Japanese population', Schizophrenia Research, vol. 88, no. 1-3, pp. 245-250. https://doi.org/10.1016/j.schres.2006.07.019

The 2′,3′-cyclic nucleotide 3′-phosphodiesterase and oligodendrocyte lineage transcription factor 2 genes do not appear to be associated with schizophrenia in the Japanese population. / Usui, Hinako; Takahashi, Nagahide; Saito, Shinichi et al.
In: Schizophrenia Research, Vol. 88, No. 1-3, 12.2006, p. 245-250.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - The 2′,3′-cyclic nucleotide 3′-phosphodiesterase and oligodendrocyte lineage transcription factor 2 genes do not appear to be associated with schizophrenia in the Japanese population

AU - Usui, Hinako

AU - Takahashi, Nagahide

AU - Saito, Shinichi

AU - Ishihara, Ryoko

AU - Aoyama, Nagisa

AU - Ikeda, Masashi

AU - Suzuki, Tatsuyo

AU - Kitajima, Tsuyoshi

AU - Yamanouchi, Yoshio

AU - Kinoshita, Yoko

AU - Yoshida, Keizo

AU - Iwata, Nakao

AU - Inada, Toshiya

AU - Ozaki, Norio

N1 - Funding Information: We thank Y. Nakamura for the technical support. This work was supported in part by research grants from the Ministry of Education, Culture, Sports, Science, and Technology of Japan, the Ministry of Health, Labor, and Welfare of Japan, and the Japan Health Sciences Foundation (Research on Health Sciences Focusing on Drug Innovation).

PY - 2006/12

Y1 - 2006/12

N2 - Several lines of evidence suggest that disturbance of myelin-related genes is associated with the etiology of schizophrenia. Recently, the 2′,3′-cyclic nucleotide 3′-phosphodiesterase (CNP) gene and the oligodendrocyte lineage transcription factor 2 (OLIG2) gene were reported to be related to the development of schizophrenia, based on the results of genetic association and microarray studies. In the present study, no significant association with schizophrenia was observed by single-marker or haplotype analysis for 6 tag SNPs of these genes (759 cases, 757 controls). These findings suggest that CNP and OLIG2 are unlikely to be related to the development of schizophrenia in the Japanese population.

AB - Several lines of evidence suggest that disturbance of myelin-related genes is associated with the etiology of schizophrenia. Recently, the 2′,3′-cyclic nucleotide 3′-phosphodiesterase (CNP) gene and the oligodendrocyte lineage transcription factor 2 (OLIG2) gene were reported to be related to the development of schizophrenia, based on the results of genetic association and microarray studies. In the present study, no significant association with schizophrenia was observed by single-marker or haplotype analysis for 6 tag SNPs of these genes (759 cases, 757 controls). These findings suggest that CNP and OLIG2 are unlikely to be related to the development of schizophrenia in the Japanese population.

KW - CNP

KW - Haplotypes

KW - Linkage disequilibrium

KW - OLIG2

KW - Schizophrenia

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AN - SCOPUS:33750612262

SN - 0920-9964

VL - 88

SP - 245

EP - 250

JO - Schizophrenia Research

JF - Schizophrenia Research

IS - 1-3

ER -

The 2′,3′-cyclic nucleotide 3′-phosphodiesterase and oligodendrocyte lineage transcription factor 2 genes do not appear to be associated with schizophrenia in the Japanese population

Abstract

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