The absence of core fucose up-regulates gnt-iii and wnt target genes: A possible mechanism for an adaptive response in terms of glycan function

Ayako Kurimoto, Shinobu Kitazume, Yasuhiko Kizuka, Kazuki Nakajima, Ritsuko Oka, Reiko Fujinawa, Hiroaki Korekane, Yoshiki Yamaguchi, Yoshinao Wada, Naoyuki Taniguchi

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25 Citations (Scopus)

Abstract

Background: Little is known about how loss of a given glycan causes adaptive regulation of other glycosylation. Results: Deficiency in core α1,6-fucose specifically up-regulates bisecting GlcNAc by enhanced gene expression of a biosynthetic enzyme GnT-III. Conclusion: Wnt signaling pathway regulates the expression of GnT-III. Significance: Wnt-mediated GnT-III up-regulation may be an adaptive response to the loss of core fucose.

Original languageEnglish
Pages (from-to)11704-11714
Number of pages11
JournalJournal of Biological Chemistry
Volume289
Issue number17
DOIs
Publication statusPublished - 25-04-2014
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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    Kurimoto, A., Kitazume, S., Kizuka, Y., Nakajima, K., Oka, R., Fujinawa, R., Korekane, H., Yamaguchi, Y., Wada, Y., & Taniguchi, N. (2014). The absence of core fucose up-regulates gnt-iii and wnt target genes: A possible mechanism for an adaptive response in terms of glycan function. Journal of Biological Chemistry, 289(17), 11704-11714. https://doi.org/10.1074/jbc.M113.502542