TY - JOUR
T1 - The absence of core fucose up-regulates gnt-iii and wnt target genes
T2 - A possible mechanism for an adaptive response in terms of glycan function
AU - Kurimoto, Ayako
AU - Kitazume, Shinobu
AU - Kizuka, Yasuhiko
AU - Nakajima, Kazuki
AU - Oka, Ritsuko
AU - Fujinawa, Reiko
AU - Korekane, Hiroaki
AU - Yamaguchi, Yoshiki
AU - Wada, Yoshinao
AU - Taniguchi, Naoyuki
PY - 2014/4/25
Y1 - 2014/4/25
N2 - Background: Little is known about how loss of a given glycan causes adaptive regulation of other glycosylation. Results: Deficiency in core α1,6-fucose specifically up-regulates bisecting GlcNAc by enhanced gene expression of a biosynthetic enzyme GnT-III. Conclusion: Wnt signaling pathway regulates the expression of GnT-III. Significance: Wnt-mediated GnT-III up-regulation may be an adaptive response to the loss of core fucose.
AB - Background: Little is known about how loss of a given glycan causes adaptive regulation of other glycosylation. Results: Deficiency in core α1,6-fucose specifically up-regulates bisecting GlcNAc by enhanced gene expression of a biosynthetic enzyme GnT-III. Conclusion: Wnt signaling pathway regulates the expression of GnT-III. Significance: Wnt-mediated GnT-III up-regulation may be an adaptive response to the loss of core fucose.
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U2 - 10.1074/jbc.M113.502542
DO - 10.1074/jbc.M113.502542
M3 - Article
C2 - 24619415
AN - SCOPUS:84899427302
SN - 0021-9258
VL - 289
SP - 11704
EP - 11714
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 17
ER -