The absence of core fucose up-regulates gnt-iii and wnt target genes: A possible mechanism for an adaptive response in terms of glycan function

Ayako Kurimoto; Shinobu Kitazume; Yasuhiko Kizuka; Kazuki Nakajima; Ritsuko Oka; Reiko Fujinawa; Hiroaki Korekane; Yoshiki Yamaguchi; Yoshinao Wada; Naoyuki Taniguchi

doi:10.1074/jbc.M113.502542

The absence of core fucose up-regulates gnt-iii and wnt target genes: A possible mechanism for an adaptive response in terms of glycan function

Ayako Kurimoto
, Shinobu Kitazume
, Yasuhiko Kizuka
, Kazuki Nakajima
, Ritsuko Oka
, Reiko Fujinawa
, Hiroaki Korekane
, Yoshiki Yamaguchi
, Yoshinao Wada
, Naoyuki Taniguchi

visiting faculty

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Abstract

Background: Little is known about how loss of a given glycan causes adaptive regulation of other glycosylation. Results: Deficiency in core α1,6-fucose specifically up-regulates bisecting GlcNAc by enhanced gene expression of a biosynthetic enzyme GnT-III. Conclusion: Wnt signaling pathway regulates the expression of GnT-III. Significance: Wnt-mediated GnT-III up-regulation may be an adaptive response to the loss of core fucose.

Original language	English
Pages (from-to)	11704-11714
Number of pages	11
Journal	Journal of Biological Chemistry
Volume	289
Issue number	17
DOIs	https://doi.org/10.1074/jbc.M113.502542
Publication status	Published - 25-04-2014

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M113.502542

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Kurimoto, A., Kitazume, S., Kizuka, Y., Nakajima, K., Oka, R., Fujinawa, R., Korekane, H., Yamaguchi, Y., Wada, Y., & Taniguchi, N. (2014). The absence of core fucose up-regulates gnt-iii and wnt target genes: A possible mechanism for an adaptive response in terms of glycan function. Journal of Biological Chemistry, 289(17), 11704-11714. https://doi.org/10.1074/jbc.M113.502542

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abstract = "Background: Little is known about how loss of a given glycan causes adaptive regulation of other glycosylation. Results: Deficiency in core α1,6-fucose specifically up-regulates bisecting GlcNAc by enhanced gene expression of a biosynthetic enzyme GnT-III. Conclusion: Wnt signaling pathway regulates the expression of GnT-III. Significance: Wnt-mediated GnT-III up-regulation may be an adaptive response to the loss of core fucose.",

author = "Ayako Kurimoto and Shinobu Kitazume and Yasuhiko Kizuka and Kazuki Nakajima and Ritsuko Oka and Reiko Fujinawa and Hiroaki Korekane and Yoshiki Yamaguchi and Yoshinao Wada and Naoyuki Taniguchi",

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doi = "10.1074/jbc.M113.502542",

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Kurimoto, A, Kitazume, S, Kizuka, Y, Nakajima, K, Oka, R, Fujinawa, R, Korekane, H, Yamaguchi, Y, Wada, Y & Taniguchi, N 2014, 'The absence of core fucose up-regulates gnt-iii and wnt target genes: A possible mechanism for an adaptive response in terms of glycan function', Journal of Biological Chemistry, vol. 289, no. 17, pp. 11704-11714. https://doi.org/10.1074/jbc.M113.502542

TY - JOUR

T1 - The absence of core fucose up-regulates gnt-iii and wnt target genes

T2 - A possible mechanism for an adaptive response in terms of glycan function

AU - Kurimoto, Ayako

AU - Kitazume, Shinobu

AU - Kizuka, Yasuhiko

AU - Nakajima, Kazuki

AU - Oka, Ritsuko

AU - Fujinawa, Reiko

AU - Korekane, Hiroaki

AU - Yamaguchi, Yoshiki

AU - Wada, Yoshinao

AU - Taniguchi, Naoyuki

PY - 2014/4/25

Y1 - 2014/4/25

N2 - Background: Little is known about how loss of a given glycan causes adaptive regulation of other glycosylation. Results: Deficiency in core α1,6-fucose specifically up-regulates bisecting GlcNAc by enhanced gene expression of a biosynthetic enzyme GnT-III. Conclusion: Wnt signaling pathway regulates the expression of GnT-III. Significance: Wnt-mediated GnT-III up-regulation may be an adaptive response to the loss of core fucose.

AB - Background: Little is known about how loss of a given glycan causes adaptive regulation of other glycosylation. Results: Deficiency in core α1,6-fucose specifically up-regulates bisecting GlcNAc by enhanced gene expression of a biosynthetic enzyme GnT-III. Conclusion: Wnt signaling pathway regulates the expression of GnT-III. Significance: Wnt-mediated GnT-III up-regulation may be an adaptive response to the loss of core fucose.

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DO - 10.1074/jbc.M113.502542

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AN - SCOPUS:84899427302

SN - 0021-9258

VL - 289

SP - 11704

EP - 11714

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 17

ER -

The absence of core fucose up-regulates gnt-iii and wnt target genes: A possible mechanism for an adaptive response in terms of glycan function

Abstract

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