The activation of mice's behavior and reduction of brain β-adrenergic receptor binding following repeated administration of antidepressant drugs

S. Nomura, J. Shimizu, N. Ukei, S. Sakaida, T. Nakazawa

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

In view of the fact that antidepressant drugs have almost no effect on a normal person's emotion and behavior, it seems necessary to examine their effects on animal behavior under abnormal, or stressful conditions. When mice were put into a water wheel apparatus, they tried to escape from the water by turning the wheel. This 'wheel-turning behavior' was activated by repeated doses of imipramine or amitriptyline. The increase was paralleled by a reduction of brain β-adrenergic receptor binding. It was speculated that chronic doses of antidepressants would increase escape behavior in mice when they were placed in a critical situation. The causal relationships between this behavioral change and β-receptor function in brain remains to be further examined.

Original languageEnglish
Pages (from-to)237-241
Number of pages5
JournalJapanese Journal of Psychopharmacology
Volume4
Issue number3
Publication statusPublished - 1984

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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