The antagonistic effects of naloxone on cycloheximide and anisomicin-induced amnesia

Tsutomu Kameyama, Toshitaka Nabeshima, Teruo Kozawa

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


The amnesia induced by cycloheximide (CXM) injected SC and by CXM or anisomycin injected ICV immediately after the training test was antagonized in combination with an opiate antagonist, naloxone (NLX). This antagonism occurred on both the passive avoidance- and escape-learning responses in a dose-dependent manner in mice. NLX alone (0.3-10.0 mg/kg) did not alter the performances of these tasks. Furthermore, the decrease in retention performance on shuttle avoidance in rats induced by CXM was also antagonized by NLX. Treatment with CXM and/or NLX did not affect spontaneous locomotor activity. The interaction of these drugs on the performance of the passive avoidance- and escape-learning and the shuttle avoidance tasks may be related to neurochemical memory processes. These results suggest than an opioid system may participate in the amnesic actions induced by protein synthesis inhibitors in these models.

Original languageEnglish
Pages (from-to)567-572
Number of pages6
JournalPharmacology, Biochemistry and Behavior
Issue number3
Publication statusPublished - 09-1986
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience


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