The BB genotype of heat-shock protein (HSP) 70-2 gene is associated with gastric pre-malignant condition in H. pylori-infected older patients

Tomomitsu Tahara, Tomoyuki Shibata, Tomiyasu Arisawa, Masakatsu Nakamura, Daisuke Yoshioka, Masaaki Okubo, Naoko Maruyama, Toshiaki Kamano, Yoshio Kamiya, Hiroshi Fujita, Mitsuo Nagasaka, Masami Iwata, Hiromi Yamashita, Hiroshi Nakano, Ichiro Hirata

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Background: Heat-shock protein (HSP) 70 plays essential roles in cellular response to a variety of environmental stresses or unfavorable conditions. A to G transition at the 1267 position of the HSP70-2 gene confers different levels of HSP70 mRNA expression. We aimed to clarify the effect of HSP70-2 polymorphism on the risk of premalignant condition, on the degree of acute or chronic inflammation in the stomach. Patients and Methods: A total of 378 individuals participated in this study. Restriction fragment length polymorphism analysis was performed for polymorphisms at 1267 of HSP70-2 gene. Prevalence of intestinal metaplasia was investigated histologically and the degree of histological gastritis in the antrum was classified according to the updated Sydney System. Results: Although a direct association was not observed between HSP70-2 polymorphism and prevalence of intestinal metaplasia, a significant association was found between the BB genotype and lower metaplasia score in individuals who were Helicobacter pylori (H. pylori) positive and aged 60 years or older (BB vs. A carriers; 0.84±0.95 vs. 1.23±1.01, p=0.0197). When individuals were divided into 3 groups according to the severity of gastric mucosal atrophy: non-atrophic gastritis (NA) group (atrophy score=0 and metaplasia score=0), severe atrophic gastritis (SA) group (atrophy score≥2 or metaplasia score≥2), and mild atrophic gastritis (MA) group (all others), the BB genotype was associated with a lower risk of severe atrophy in the SA subgroup (adjusted odds ratio=0.37, 95% confidence interval =0.16-0.84, p=0.0172). Conclusion: The BB genotype of HSP70-2 gene is associated with a reduced risk of gastric pre-malignant condition in H. pylori-infected older individuals.

Original languageEnglish
Pages (from-to)3453-3458
Number of pages6
JournalAnticancer research
Issue number8
Publication statusPublished - 08-2009

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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