The brain-derived neurotrophic factor (BDNF) polymorphism Val66Met is associated with neither serum BDNF level nor response to selective serotonin reuptake inhibitors in depressed Japanese patients

Reiji Yoshimura, Taro Kishi, Akihito Suzuki, Wakako Umene-Nakano, Atsuko Ikenouchi-Sugita, Hikaru Hori, Koichi Otani, Nakao Iwata, Jun Nakamura

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Background: We investigated the relationship between a brain-derived neurotrophic factor (BDNF) polymorphism (Val66Met) and the clinical response of patients with major depressive disorder to selective serotonin reuptake inhibitors (SSRIs; here, paroxetine and sertraline). In addition, serum BDNF levels in these patients were considered together with the clinical response. Methods: A total of 132 patients who met the DSM-IV criteria for major depressive disorder were enrolled in the study. 54 of these patients were male and 78 were female (age range, 20-74. years; mean ± S.D., 51 ± 15). The patients' clinical improvement was evaluated using the 17-item Hamilton Rating Scale for Depression (HAMD-17) before (T0) and at 8. weeks after the administration of SSRI treatment (T8). Patients with at least a 50% decrease in the HAMD-17 score were classified as responders. Results: No correlation was observed between the BDNF Val66Met polymorphism and response to SSRIs or between the BDNF Val66Met polymorphism and serum BDNF levels at T0. An inverse correlation was found between serum BDNF levels and HAMD-17 scores at T0. Conclusions: These results suggest that the BDNF Val66Met polymorphism is independent of both the response to SSRI treatment and serum BDNF levels. The findings in the present study reconfirm that the serum BDNF level is a state biomarker for depression.

Original languageEnglish
Pages (from-to)1022-1025
Number of pages4
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume35
Issue number4
DOIs
Publication statusPublished - 01-06-2011

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Biological Psychiatry

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