The Bysl gene product, bystin, is essential for survival of mouse embryos

Rui Aoki, Nao Suzuki, Bibhash C. Paria, Kazuhiro Sugihara, Tomoya O. Akama, Gerhard Raab, Masaya Miyoshi, Daita Nadano, Michiko N. Fukuda

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


Human bystin is a cytoplasmic protein directly binding to trophinin, a cell adhesion molecule potentially involved in human embryo implantation. The present study shows that bystin is expressed in luminal and glandular epithelia in the mouse uterus at peri-implantation stages. In fertilized embryos, bystin was not seen until blastocyst stage. Bystin expression started during hatching and increased in expanded blastocyst. However, bystin apparently disappeared from the blastocyst during implantation. After implantation bystin re-appeared in the epiblast. Targeted disruption of the mouse bystin gene, Bysl, resulted in embryonic lethality shortly after implantation, indicating that bystin is essential for survival of mouse embryos.

Original languageEnglish
Pages (from-to)6062-6068
Number of pages7
JournalFEBS Letters
Issue number26
Publication statusPublished - 13-11-2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology


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