The Bysl gene product, bystin, is essential for survival of mouse embryos

Rui Aoki; Nao Suzuki; Bibhash C. Paria; Kazuhiro Sugihara; Tomoya O. Akama; Gerhard Raab; Masaya Miyoshi; Daita Nadano; Michiko N. Fukuda

doi:10.1016/j.febslet.2006.09.072

The Bysl gene product, bystin, is essential for survival of mouse embryos

Rui Aoki, Nao Suzuki, Bibhash C. Paria, Kazuhiro Sugihara, Tomoya O. Akama, Gerhard Raab, Masaya Miyoshi, Daita Nadano, Michiko N. Fukuda

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Human bystin is a cytoplasmic protein directly binding to trophinin, a cell adhesion molecule potentially involved in human embryo implantation. The present study shows that bystin is expressed in luminal and glandular epithelia in the mouse uterus at peri-implantation stages. In fertilized embryos, bystin was not seen until blastocyst stage. Bystin expression started during hatching and increased in expanded blastocyst. However, bystin apparently disappeared from the blastocyst during implantation. After implantation bystin re-appeared in the epiblast. Targeted disruption of the mouse bystin gene, Bysl, resulted in embryonic lethality shortly after implantation, indicating that bystin is essential for survival of mouse embryos.

Original language	English
Pages (from-to)	6062-6068
Number of pages	7
Journal	FEBS Letters
Volume	580
Issue number	26
DOIs	https://doi.org/10.1016/j.febslet.2006.09.072
Publication status	Published - 13-11-2006
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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10.1016/j.febslet.2006.09.072

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@article{b87d6ab3dd6b4143a9ad61b6fb7bd613,

title = "The Bysl gene product, bystin, is essential for survival of mouse embryos",

abstract = "Human bystin is a cytoplasmic protein directly binding to trophinin, a cell adhesion molecule potentially involved in human embryo implantation. The present study shows that bystin is expressed in luminal and glandular epithelia in the mouse uterus at peri-implantation stages. In fertilized embryos, bystin was not seen until blastocyst stage. Bystin expression started during hatching and increased in expanded blastocyst. However, bystin apparently disappeared from the blastocyst during implantation. After implantation bystin re-appeared in the epiblast. Targeted disruption of the mouse bystin gene, Bysl, resulted in embryonic lethality shortly after implantation, indicating that bystin is essential for survival of mouse embryos.",

author = "Rui Aoki and Nao Suzuki and Paria, {Bibhash C.} and Kazuhiro Sugihara and Akama, {Tomoya O.} and Gerhard Raab and Masaya Miyoshi and Daita Nadano and Fukuda, {Michiko N.}",

note = "Funding Information: This study was supported by NIH Grant HD34108 and DoD Grant W81XWH-04-1-0917. The authors thank Dr. Elise Lamar for editing the manuscript, and Shuk-Man Wong for technical assistance.",

year = "2006",

month = nov,

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doi = "10.1016/j.febslet.2006.09.072",

language = "English",

volume = "580",

pages = "6062--6068",

journal = "FEBS Letters",

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T1 - The Bysl gene product, bystin, is essential for survival of mouse embryos

AU - Aoki, Rui

AU - Suzuki, Nao

AU - Paria, Bibhash C.

AU - Sugihara, Kazuhiro

AU - Akama, Tomoya O.

AU - Raab, Gerhard

AU - Miyoshi, Masaya

AU - Nadano, Daita

AU - Fukuda, Michiko N.

N1 - Funding Information: This study was supported by NIH Grant HD34108 and DoD Grant W81XWH-04-1-0917. The authors thank Dr. Elise Lamar for editing the manuscript, and Shuk-Man Wong for technical assistance.

PY - 2006/11/13

Y1 - 2006/11/13

N2 - Human bystin is a cytoplasmic protein directly binding to trophinin, a cell adhesion molecule potentially involved in human embryo implantation. The present study shows that bystin is expressed in luminal and glandular epithelia in the mouse uterus at peri-implantation stages. In fertilized embryos, bystin was not seen until blastocyst stage. Bystin expression started during hatching and increased in expanded blastocyst. However, bystin apparently disappeared from the blastocyst during implantation. After implantation bystin re-appeared in the epiblast. Targeted disruption of the mouse bystin gene, Bysl, resulted in embryonic lethality shortly after implantation, indicating that bystin is essential for survival of mouse embryos.

AB - Human bystin is a cytoplasmic protein directly binding to trophinin, a cell adhesion molecule potentially involved in human embryo implantation. The present study shows that bystin is expressed in luminal and glandular epithelia in the mouse uterus at peri-implantation stages. In fertilized embryos, bystin was not seen until blastocyst stage. Bystin expression started during hatching and increased in expanded blastocyst. However, bystin apparently disappeared from the blastocyst during implantation. After implantation bystin re-appeared in the epiblast. Targeted disruption of the mouse bystin gene, Bysl, resulted in embryonic lethality shortly after implantation, indicating that bystin is essential for survival of mouse embryos.

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SN - 0014-5793

VL - 580

SP - 6062

EP - 6068

JO - FEBS Letters

JF - FEBS Letters

IS - 26

ER -

The Bysl gene product, bystin, is essential for survival of mouse embryos

Abstract

All Science Journal Classification (ASJC) codes

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