The characteristics of the patients with radiologically severe cervical ossification of the posterior longitudinal ligament of the spine: A CT-based multicenter cross-sectional study

Kanji Mori, Toshitaka Yoshii, Takashi Hirai, Narihito Nagoshi, Kazuhiro Takeuchi, Shuta Ushio, Akio Iwanami, Tsuyoshi Yamada, Shoji Seki, Takashi Tsuji, Kanehiro Fujiyoshi, Mitsuru Furukawa, Soraya Nishimura, Kanichiro Wada, Takeo Furuya, Yukihiro Matsuyama, Tomohiko Hasegawa, Katsushi Takeshita, Atsushi Kimura, Masahiko AbematsuHirotaka Haro, Tetsuro Ohba, Masahiko Watanabe, Hiroyuki Katoh, Kei Watanabe, Hiroshi Ozawa, Haruo Kanno, Shiro Imagama, Kei Ando, Shunsuke Fujibayashi, Masao Koda, Masashi Yamazaki, Morio Matsumoto, Masaya Nakamura, Atsushi Okawa, Yoshiharu Kawaguchi

Research output: Contribution to journalArticle

Abstract

Background: Ossification of the posterior longitudinal ligament of the spine (OPLL) is characterized by heterotopic bone formation in the posterior longitudinal ligament of the spine. We know that the size and distribution of the ossified lesions in patients with OPLL are different in each case. However, the characteristics of the patients with radiologically severe cervical OPLL remain unknown. Methods: The participants of our study were symptomatic patients with cervical OPLL who were diagnosed by standard radiographs of the cervical spine. Whole-spine CT data and demographic data such as age and sex were obtained from 20 institutions belonging to the Japanese Multicenter Research Organization for Ossification of the Spinal Ligament. According to the number of the levels involved by OPLL, we stratified the patients into two subgroups: severe group (S-group) and non-severe group (NS-group) to delineate the characteristics of radiologically severe patients with cervical OPLL. We also evaluated the most compressed level and the degree of occupying ratio of cervical spinal canal by OPLL at the most compressed level. Results: A total of 234 patients with a mean age of 65 years were recruited. The S-group consisted of 48 patients (21%, 12 females and 36 males) and the NS-group consisted of 92 patients (79%, 22 females and 70 males). The mean age of males in the S-group (68 years old) was significantly higher than that of males in the NS-group (64 years old); however there was no significant difference in the mean age in females between the S-group (69 years old) and the NS-group (66 years old). No significant difference of body mass index, ossification of the nuchal ligament-positivity and presence of diabetes mellitus were found between the S- and the NS-group. Conclusions: It is likely that the manner of extension of cervical OPLL is different between male and female patients.

Original languageEnglish
JournalJournal of Orthopaedic Science
DOIs
Publication statusAccepted/In press - 01-01-2019

Fingerprint

Longitudinal Ligaments
Spine
Cross-Sectional Studies
Osteogenesis
Ligaments
Ossification of the posterior longitudinal ligament of the spine
Spinal Canal
Diabetes Mellitus
Body Mass Index
Demography
Organizations

All Science Journal Classification (ASJC) codes

  • Surgery
  • Orthopedics and Sports Medicine

Cite this

Mori, Kanji ; Yoshii, Toshitaka ; Hirai, Takashi ; Nagoshi, Narihito ; Takeuchi, Kazuhiro ; Ushio, Shuta ; Iwanami, Akio ; Yamada, Tsuyoshi ; Seki, Shoji ; Tsuji, Takashi ; Fujiyoshi, Kanehiro ; Furukawa, Mitsuru ; Nishimura, Soraya ; Wada, Kanichiro ; Furuya, Takeo ; Matsuyama, Yukihiro ; Hasegawa, Tomohiko ; Takeshita, Katsushi ; Kimura, Atsushi ; Abematsu, Masahiko ; Haro, Hirotaka ; Ohba, Tetsuro ; Watanabe, Masahiko ; Katoh, Hiroyuki ; Watanabe, Kei ; Ozawa, Hiroshi ; Kanno, Haruo ; Imagama, Shiro ; Ando, Kei ; Fujibayashi, Shunsuke ; Koda, Masao ; Yamazaki, Masashi ; Matsumoto, Morio ; Nakamura, Masaya ; Okawa, Atsushi ; Kawaguchi, Yoshiharu. / The characteristics of the patients with radiologically severe cervical ossification of the posterior longitudinal ligament of the spine : A CT-based multicenter cross-sectional study. In: Journal of Orthopaedic Science. 2019.
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title = "The characteristics of the patients with radiologically severe cervical ossification of the posterior longitudinal ligament of the spine: A CT-based multicenter cross-sectional study",
abstract = "Background: Ossification of the posterior longitudinal ligament of the spine (OPLL) is characterized by heterotopic bone formation in the posterior longitudinal ligament of the spine. We know that the size and distribution of the ossified lesions in patients with OPLL are different in each case. However, the characteristics of the patients with radiologically severe cervical OPLL remain unknown. Methods: The participants of our study were symptomatic patients with cervical OPLL who were diagnosed by standard radiographs of the cervical spine. Whole-spine CT data and demographic data such as age and sex were obtained from 20 institutions belonging to the Japanese Multicenter Research Organization for Ossification of the Spinal Ligament. According to the number of the levels involved by OPLL, we stratified the patients into two subgroups: severe group (S-group) and non-severe group (NS-group) to delineate the characteristics of radiologically severe patients with cervical OPLL. We also evaluated the most compressed level and the degree of occupying ratio of cervical spinal canal by OPLL at the most compressed level. Results: A total of 234 patients with a mean age of 65 years were recruited. The S-group consisted of 48 patients (21{\%}, 12 females and 36 males) and the NS-group consisted of 92 patients (79{\%}, 22 females and 70 males). The mean age of males in the S-group (68 years old) was significantly higher than that of males in the NS-group (64 years old); however there was no significant difference in the mean age in females between the S-group (69 years old) and the NS-group (66 years old). No significant difference of body mass index, ossification of the nuchal ligament-positivity and presence of diabetes mellitus were found between the S- and the NS-group. Conclusions: It is likely that the manner of extension of cervical OPLL is different between male and female patients.",
author = "Kanji Mori and Toshitaka Yoshii and Takashi Hirai and Narihito Nagoshi and Kazuhiro Takeuchi and Shuta Ushio and Akio Iwanami and Tsuyoshi Yamada and Shoji Seki and Takashi Tsuji and Kanehiro Fujiyoshi and Mitsuru Furukawa and Soraya Nishimura and Kanichiro Wada and Takeo Furuya and Yukihiro Matsuyama and Tomohiko Hasegawa and Katsushi Takeshita and Atsushi Kimura and Masahiko Abematsu and Hirotaka Haro and Tetsuro Ohba and Masahiko Watanabe and Hiroyuki Katoh and Kei Watanabe and Hiroshi Ozawa and Haruo Kanno and Shiro Imagama and Kei Ando and Shunsuke Fujibayashi and Masao Koda and Masashi Yamazaki and Morio Matsumoto and Masaya Nakamura and Atsushi Okawa and Yoshiharu Kawaguchi",
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language = "English",
journal = "Journal of Orthopaedic Science",
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Mori, K, Yoshii, T, Hirai, T, Nagoshi, N, Takeuchi, K, Ushio, S, Iwanami, A, Yamada, T, Seki, S, Tsuji, T, Fujiyoshi, K, Furukawa, M, Nishimura, S, Wada, K, Furuya, T, Matsuyama, Y, Hasegawa, T, Takeshita, K, Kimura, A, Abematsu, M, Haro, H, Ohba, T, Watanabe, M, Katoh, H, Watanabe, K, Ozawa, H, Kanno, H, Imagama, S, Ando, K, Fujibayashi, S, Koda, M, Yamazaki, M, Matsumoto, M, Nakamura, M, Okawa, A & Kawaguchi, Y 2019, 'The characteristics of the patients with radiologically severe cervical ossification of the posterior longitudinal ligament of the spine: A CT-based multicenter cross-sectional study', Journal of Orthopaedic Science. https://doi.org/10.1016/j.jos.2019.09.018

The characteristics of the patients with radiologically severe cervical ossification of the posterior longitudinal ligament of the spine : A CT-based multicenter cross-sectional study. / Mori, Kanji; Yoshii, Toshitaka; Hirai, Takashi; Nagoshi, Narihito; Takeuchi, Kazuhiro; Ushio, Shuta; Iwanami, Akio; Yamada, Tsuyoshi; Seki, Shoji; Tsuji, Takashi; Fujiyoshi, Kanehiro; Furukawa, Mitsuru; Nishimura, Soraya; Wada, Kanichiro; Furuya, Takeo; Matsuyama, Yukihiro; Hasegawa, Tomohiko; Takeshita, Katsushi; Kimura, Atsushi; Abematsu, Masahiko; Haro, Hirotaka; Ohba, Tetsuro; Watanabe, Masahiko; Katoh, Hiroyuki; Watanabe, Kei; Ozawa, Hiroshi; Kanno, Haruo; Imagama, Shiro; Ando, Kei; Fujibayashi, Shunsuke; Koda, Masao; Yamazaki, Masashi; Matsumoto, Morio; Nakamura, Masaya; Okawa, Atsushi; Kawaguchi, Yoshiharu.

In: Journal of Orthopaedic Science, 01.01.2019.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The characteristics of the patients with radiologically severe cervical ossification of the posterior longitudinal ligament of the spine

T2 - A CT-based multicenter cross-sectional study

AU - Mori, Kanji

AU - Yoshii, Toshitaka

AU - Hirai, Takashi

AU - Nagoshi, Narihito

AU - Takeuchi, Kazuhiro

AU - Ushio, Shuta

AU - Iwanami, Akio

AU - Yamada, Tsuyoshi

AU - Seki, Shoji

AU - Tsuji, Takashi

AU - Fujiyoshi, Kanehiro

AU - Furukawa, Mitsuru

AU - Nishimura, Soraya

AU - Wada, Kanichiro

AU - Furuya, Takeo

AU - Matsuyama, Yukihiro

AU - Hasegawa, Tomohiko

AU - Takeshita, Katsushi

AU - Kimura, Atsushi

AU - Abematsu, Masahiko

AU - Haro, Hirotaka

AU - Ohba, Tetsuro

AU - Watanabe, Masahiko

AU - Katoh, Hiroyuki

AU - Watanabe, Kei

AU - Ozawa, Hiroshi

AU - Kanno, Haruo

AU - Imagama, Shiro

AU - Ando, Kei

AU - Fujibayashi, Shunsuke

AU - Koda, Masao

AU - Yamazaki, Masashi

AU - Matsumoto, Morio

AU - Nakamura, Masaya

AU - Okawa, Atsushi

AU - Kawaguchi, Yoshiharu

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: Ossification of the posterior longitudinal ligament of the spine (OPLL) is characterized by heterotopic bone formation in the posterior longitudinal ligament of the spine. We know that the size and distribution of the ossified lesions in patients with OPLL are different in each case. However, the characteristics of the patients with radiologically severe cervical OPLL remain unknown. Methods: The participants of our study were symptomatic patients with cervical OPLL who were diagnosed by standard radiographs of the cervical spine. Whole-spine CT data and demographic data such as age and sex were obtained from 20 institutions belonging to the Japanese Multicenter Research Organization for Ossification of the Spinal Ligament. According to the number of the levels involved by OPLL, we stratified the patients into two subgroups: severe group (S-group) and non-severe group (NS-group) to delineate the characteristics of radiologically severe patients with cervical OPLL. We also evaluated the most compressed level and the degree of occupying ratio of cervical spinal canal by OPLL at the most compressed level. Results: A total of 234 patients with a mean age of 65 years were recruited. The S-group consisted of 48 patients (21%, 12 females and 36 males) and the NS-group consisted of 92 patients (79%, 22 females and 70 males). The mean age of males in the S-group (68 years old) was significantly higher than that of males in the NS-group (64 years old); however there was no significant difference in the mean age in females between the S-group (69 years old) and the NS-group (66 years old). No significant difference of body mass index, ossification of the nuchal ligament-positivity and presence of diabetes mellitus were found between the S- and the NS-group. Conclusions: It is likely that the manner of extension of cervical OPLL is different between male and female patients.

AB - Background: Ossification of the posterior longitudinal ligament of the spine (OPLL) is characterized by heterotopic bone formation in the posterior longitudinal ligament of the spine. We know that the size and distribution of the ossified lesions in patients with OPLL are different in each case. However, the characteristics of the patients with radiologically severe cervical OPLL remain unknown. Methods: The participants of our study were symptomatic patients with cervical OPLL who were diagnosed by standard radiographs of the cervical spine. Whole-spine CT data and demographic data such as age and sex were obtained from 20 institutions belonging to the Japanese Multicenter Research Organization for Ossification of the Spinal Ligament. According to the number of the levels involved by OPLL, we stratified the patients into two subgroups: severe group (S-group) and non-severe group (NS-group) to delineate the characteristics of radiologically severe patients with cervical OPLL. We also evaluated the most compressed level and the degree of occupying ratio of cervical spinal canal by OPLL at the most compressed level. Results: A total of 234 patients with a mean age of 65 years were recruited. The S-group consisted of 48 patients (21%, 12 females and 36 males) and the NS-group consisted of 92 patients (79%, 22 females and 70 males). The mean age of males in the S-group (68 years old) was significantly higher than that of males in the NS-group (64 years old); however there was no significant difference in the mean age in females between the S-group (69 years old) and the NS-group (66 years old). No significant difference of body mass index, ossification of the nuchal ligament-positivity and presence of diabetes mellitus were found between the S- and the NS-group. Conclusions: It is likely that the manner of extension of cervical OPLL is different between male and female patients.

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DO - 10.1016/j.jos.2019.09.018

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