The clinical course of surgically treated pleomorphic carcinoma of the lung

Ken Onodera, Akira Sakurada, Hideki Mitomo, Fumihiko Hoshil, Yasushi Matsuda, Masafumi Noda, Yasushi Hoshikawa, Chiaki Endo, Yoshinori Okada

Research output: Contribution to journalArticle

Abstract

Objective. Pleomorphic carcinoma of the lung is a histological type that was first proposed in 1999. This tumor is rare and accounts for approximately 1.6-2.6% of all cases of lung cancer; thus, to date, few studies have described the clinical course of surgical cases. Methods. The characteristics, treatments, histological parameters, and outcomes of 13 patients with pleomorphic carcinoma of the lung who underwent pulmonary resection at Tohoku University from 2007 to 2013 were studied. Results. The ages of the patients ranged from 41 to 84 years (mean, 67 years; male, n=9; female, n=4). Lobectomy and partial resection were performed for 11 (bilobectomy, n= 1) and 2 patients, respectively. Seven patients experienced postoperative recurrence within 6 months; 5 of the 7 patients died. Disease-free survival ranged from 38 to 2, 801 days (median, 562 days). One patient with single brain metastasis at the time of the initial diagnosis underwent pulmonary resection and received gamma knife treatment. Relapse was observed at the supraclavicular lymph node and was treated with chemotherapy. A complete response was achieved, and this patient remains alive without evident disease at 1, 816 days. Conclusion. Although pleomorphic carcinoma of the lung has a poor prognosis and the efficacy of chemotherapy in treating it is unclear, our results indicate that a sub-section of the population may show a good prognosis.

Original languageEnglish
Pages (from-to)8-11
Number of pages4
JournalJapanese Journal of Lung Cancer
Volume57
Issue number1
DOIs
Publication statusPublished - 01-01-2017

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Carcinoma
Lung
Recurrence
Drug Therapy
Disease-Free Survival
Lung Neoplasms
Lymph Nodes
Neoplasm Metastasis
Brain
Therapeutics
Population
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Pulmonary and Respiratory Medicine

Cite this

Onodera, K., Sakurada, A., Mitomo, H., Hoshil, F., Matsuda, Y., Noda, M., ... Okada, Y. (2017). The clinical course of surgically treated pleomorphic carcinoma of the lung. Japanese Journal of Lung Cancer, 57(1), 8-11. https://doi.org/10.2482/haigan.57.8
Onodera, Ken ; Sakurada, Akira ; Mitomo, Hideki ; Hoshil, Fumihiko ; Matsuda, Yasushi ; Noda, Masafumi ; Hoshikawa, Yasushi ; Endo, Chiaki ; Okada, Yoshinori. / The clinical course of surgically treated pleomorphic carcinoma of the lung. In: Japanese Journal of Lung Cancer. 2017 ; Vol. 57, No. 1. pp. 8-11.
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Onodera, K, Sakurada, A, Mitomo, H, Hoshil, F, Matsuda, Y, Noda, M, Hoshikawa, Y, Endo, C & Okada, Y 2017, 'The clinical course of surgically treated pleomorphic carcinoma of the lung', Japanese Journal of Lung Cancer, vol. 57, no. 1, pp. 8-11. https://doi.org/10.2482/haigan.57.8

The clinical course of surgically treated pleomorphic carcinoma of the lung. / Onodera, Ken; Sakurada, Akira; Mitomo, Hideki; Hoshil, Fumihiko; Matsuda, Yasushi; Noda, Masafumi; Hoshikawa, Yasushi; Endo, Chiaki; Okada, Yoshinori.

In: Japanese Journal of Lung Cancer, Vol. 57, No. 1, 01.01.2017, p. 8-11.

Research output: Contribution to journalArticle

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AU - Onodera, Ken

AU - Sakurada, Akira

AU - Mitomo, Hideki

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AU - Matsuda, Yasushi

AU - Noda, Masafumi

AU - Hoshikawa, Yasushi

AU - Endo, Chiaki

AU - Okada, Yoshinori

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N2 - Objective. Pleomorphic carcinoma of the lung is a histological type that was first proposed in 1999. This tumor is rare and accounts for approximately 1.6-2.6% of all cases of lung cancer; thus, to date, few studies have described the clinical course of surgical cases. Methods. The characteristics, treatments, histological parameters, and outcomes of 13 patients with pleomorphic carcinoma of the lung who underwent pulmonary resection at Tohoku University from 2007 to 2013 were studied. Results. The ages of the patients ranged from 41 to 84 years (mean, 67 years; male, n=9; female, n=4). Lobectomy and partial resection were performed for 11 (bilobectomy, n= 1) and 2 patients, respectively. Seven patients experienced postoperative recurrence within 6 months; 5 of the 7 patients died. Disease-free survival ranged from 38 to 2, 801 days (median, 562 days). One patient with single brain metastasis at the time of the initial diagnosis underwent pulmonary resection and received gamma knife treatment. Relapse was observed at the supraclavicular lymph node and was treated with chemotherapy. A complete response was achieved, and this patient remains alive without evident disease at 1, 816 days. Conclusion. Although pleomorphic carcinoma of the lung has a poor prognosis and the efficacy of chemotherapy in treating it is unclear, our results indicate that a sub-section of the population may show a good prognosis.

AB - Objective. Pleomorphic carcinoma of the lung is a histological type that was first proposed in 1999. This tumor is rare and accounts for approximately 1.6-2.6% of all cases of lung cancer; thus, to date, few studies have described the clinical course of surgical cases. Methods. The characteristics, treatments, histological parameters, and outcomes of 13 patients with pleomorphic carcinoma of the lung who underwent pulmonary resection at Tohoku University from 2007 to 2013 were studied. Results. The ages of the patients ranged from 41 to 84 years (mean, 67 years; male, n=9; female, n=4). Lobectomy and partial resection were performed for 11 (bilobectomy, n= 1) and 2 patients, respectively. Seven patients experienced postoperative recurrence within 6 months; 5 of the 7 patients died. Disease-free survival ranged from 38 to 2, 801 days (median, 562 days). One patient with single brain metastasis at the time of the initial diagnosis underwent pulmonary resection and received gamma knife treatment. Relapse was observed at the supraclavicular lymph node and was treated with chemotherapy. A complete response was achieved, and this patient remains alive without evident disease at 1, 816 days. Conclusion. Although pleomorphic carcinoma of the lung has a poor prognosis and the efficacy of chemotherapy in treating it is unclear, our results indicate that a sub-section of the population may show a good prognosis.

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Onodera K, Sakurada A, Mitomo H, Hoshil F, Matsuda Y, Noda M et al. The clinical course of surgically treated pleomorphic carcinoma of the lung. Japanese Journal of Lung Cancer. 2017 Jan 1;57(1):8-11. https://doi.org/10.2482/haigan.57.8