The clinical relevance of oliguria in the critically ill patient: Analysis of a large observational database

Jean Louis Vincent, Andrew Ferguson, Peter Pickkers, Stephan M. Jakob, Ulrich Jaschinski, Ghaleb A. Almekhlafi, Marc Leone, Majid Mokhtari, Luis E. Fontes, Philippe R. Bauer, Yasser Sakr, Esmael Tomas, Eric Amisi Bibonge, Boubaker Charra, Mamoun Faroudy, Linda Doedens, Zane Farina, David Adler, Cecile Balkema, Adri KokSami Alaya, Hedi Gharsallah, Dritan Muzha, Atanas Temelkov, Georgi Georgiev, Georgi Simeonov, Georgi Tsaryanski, Silvi Georgiev, Ali Seliman, Srdan Vrankovic, Zeljko Vucicevic, Ivan Gornik, Bruno Barsic, Ino Husedzinovic, Pavel Pavlik, Jan Manak, Eva Kieslichova, Radovan Turek, Michal Fischer, Radka Valkova, Lukas Dadak, Pavel Dostal, Jan Malaska, Roman Hajek, Alexandra Židková, Pavel Lavicka, Joel Starkopf, Zurab Kheladze, Mamuka Chkhaidze, Vakhtang Kaloiani, Laszlo Medve, Agnes Sarkany, Ildiko Kremer, Zsuzsa Marjanek, Peter Tamasi, Inga Krupnova, Indulis Vanags, Viesturs Liguts, Vidas Pilvinis, Saulius Vosylius, Gintautas Kekstas, Mindaugas Balciunas, Julia Kolbusz, Andrzej Kübler, Beata Mielczarek, Malgorzata Mikaszewska-Sokolewicz, Katarzyna Kotfis, Barbara Tamowicz, Wiktor Sulkowski, Piotr Smuszkiewicz, Andrzej Pihowicz, Ewa Trejnowska, Natalia Hagau, Daniela Filipescu, Gabriela Droc, Mary Nicoleta Lupu, Alexandru Nica, Radu Stoica, Dana Rodica Tomescu, Dacia Laurentia Constantinescu, Georgica M. Valcoreanu Zbaganu, Adriana Slavcovici, Vladmir Bagin, Dmitry Belsky, Shamil Palyutin, Sergey Shlyapnikov, D. Bikkulova, Alexey Gritsan, Gulyaeva Natalia, Evgeny Makarenko, Vladimir Kokhno, Alla Tolkach, Evgeny Kokarev, Boris Belotserkovskiy, Konstantin Zolotukhin, Vladimir Kulabukhov, Ljiljana Soskic, Ivan Palibrk, Radmilo Jankovic, Bojan Jovanovic, Milena Pandurovic, Vesna Bumbasirevic, Boris Uljarevic, Maja Surbatovic, Nebojsa Ladjevic, Garri Slobodianiuk, Viliam Sobona, Andrea Cikova, Andrea Gebhardtova, Cao Jun, Sun Yunbo, Jun Dong, Sui Feng, Meili Duan, Yuan Xu, Xiaoyan Xue, Tieying Gao, Xue Zhong Xing, Xin Zhao, Chao Hong Li, Gengxihua Gengxihua, Huiqiong Tan, Jingqing Xu, Li Jiang, Qin Tiehe, Qin Bingyu, Qindong Shi, Zheng Lv, Liping Zhang, Liu Jingtao, Zheng Zhen, Zheng Wang, Tie Hua Wang, Liu Yuhong, Qian Zhai, Ying Chen, Chunting Wang, Wei Jiang, Wang Ruilan, Youdai Chen, Huang Xiaobo, Huiqing Ge, Tang Yan, Cui Yuhui, Jiuzhi Zhang, Fu Jian-Hong, Hong Zhu, Feifei Huo, Yushan Wang, Chao Li, Ma Zhuang, Zengxiang Ma, Jian Sun, Liuqingyue Liuqingyue, Mingshi Yang, Jianbiao Meng, Shaolin Ma, Yan Kang, Li Yu, Qianyi Peng, Yu Wei, Wei Zhang, Renhua Sun, Alwin Yeung, Wing Lun Wan, K. Kai Cheuk Sin, Kar Lung Lee, Meri Wijanti, Untung Widodo, Halim Samsirun, Tantani Sugiman, Calcarina Wisudarti, Tinni T. Maskoen, Noritaka Hata, Yoshiro Kobe, Osamu Nishida, Dai Miyazaki, Shin Nunomiya, Shigehiko Uchino, Nobuya Kitamura, Koichi Yamashita, Satoru Hashimoto, Hidetada Fukushima, Nik Azman Nik Adib, Li Ling Tai, Bill Tony, Rodolfo Roman Bigornia, Rodolfo Roman Bigornia, Jose Emmanuel Palo, Somnath Chatterjee, Bee Hong Tan, Andrew Kong, Shirley Goh, Chien Chang Lee, Chaicharn Pothirat, Bodin Khwannimit, Pongdhep Theerawit, Prapaporn Pornsuriyasak, Annop Piriyapatsom, Ahmed Mukhtar, Ahmed Nabil Hamdy, Hisham Hosny, Ali Ashraf, Majid Mokhtari, Shiva Nowruzinia, Amir Hossein Lotfi, Farid Zand, Reza Nikandish, Omid Moradi Moghaddam, Jonathan Cohen, Oded Sold, Tacla Sfeir, Alaa Yasin Hasan, Dena Abugaber, Habib Ahmad, Tarek Tantawy, Salim Baharoom, Haifa Algethamy, Anas Amr, Ghaleb Almekhlafi, Ramazan Coskun, Murat Sungur, Ahmet Cosar, Bülent Güçyetmez, Oktay Demirkiran, Evren Senturk, Hulya Ulusoy, Hakan Korkut Atalan, Simay Serin, Ismail Kati, Zainab Alnassrawi, Ayesha Almemari, Kalpana Krishnareddy, Sayed Kashef, Asad Alsabbah, Germain Poirier, John C. Marshall, Margaret Herridge, Rosangela Fernandez-Medero, Gerard Fulda, Sharon Banschbach, Juan Quintero, Elizabeth Schroeder, Corinna Sicoutris, Renaud Gueret, Rahul Kashyap, Philippe Bauer, Rahul Nanchal, Richard G. Wunderink, Edgar Jimenez, Andrea Ryan, Denvir Prince, John Edington, Frank Van Haren, Andrew Bersten, David J. Hawkins, Myrene Kilminster, David Sturgess, Marc Ziegenfuss, Stephanie O' Connor, Jeffrey Lipman, Lewis Campbell, Rick McAllister, Brigit Roberts, Patricia Williams, Rachael Parke, Patrick Seigne, Ross Freebairn, Daniel Nistor, Chantal Oxley, Paul Young, Ricardo Valentini, Nestor Wainsztein, Pablo Comignani, Maria Casaretto, Giselle Sutton, Paula Villegas, Cayerano Galletti, Jorge Neira, Daniel Rovira, Jorge Hidalgo, Freddy Sandi, Eliana Caser, Marlus M. Thompson, Mariza D'Agostino Dias, Luis E. Fontes, Maria C. Lunardi, Nazah C. Youssef, Suzana Lobo, Ricardo Silva, Joao A. Sales, Lina Madeira Campos Melo, Mirella Oliveira, Mariza Fonte, Cintia Grion, Carlos Feijo, Valaria Rezende, Murillo Assuncao, Ana P. Neves, Pablo Gusman, Dyanne Dalcomune, Cassiano Teixeira, Keitiane Kaefer, Israel Maia, Vicente Souza Dantas, Rubens Costa Filho, Fabio Amorim, Maria Assef, Paulo Schiavetto, Joao Houly, Fabiano Bianchi, Fernando Dias, Carla Avila, Leila Rego, Priscylla Castro, Joel Passos, Ciro Mendes, Cintia Grion, Giovana Colozza Mecatti, Marcia Ferrreira, Vivian Irineu, Marcio Guerreiro, Sebastian Ugarte, Vinko Tomicic, Christian Godoy, Wagner Samaniego, Ignacio Escamilla, Luis F. Castro Castro, Giovanni Libreros Duque, Diego Diaz-Guio, Frederico Benítez, Arturo Guerra Urrego, Ricardo Buitrago, Guillermo Ortiz, Maria C. Villalba Gaviria, Donat Salas, Jorge Ramirez-Arce, Estuardo Salgado, Diego Morocho, Jose Vergara, Miguel Chung Sang, Carlos Orellana-Jimenez, Lorena Garrido, Oscar Diaz, Dabor Resiere, Carlos Osorio, Alberto De La Vega, Raul Carrillo, Victor Sanchez, Asisclo Villagomez, Ricardo Martinez Zubieta, Maria Sandia, Maycotte Zalatiel, Manuel Poblano, Daniel Rodriguez Gonzalez, Fernando Arrazola, Leal L. Juan Francisco, Silvio A. Ñamendys-Silva, Rosalinda Guerra Moya, Marco Hernandez, Diego M. Rodriguez Cadena, Ines Lopez Islas, Carlos M. Ballesteros Zarzavilla, Alfredo Matos, Indira Oyanguren, Jorge Cerna, Rosario Quispe Sierra, Rocio Jimenez, Luis Castillo, Ramizan Ocal, Atilla Sencan, Silvia M. Mareque Gianoni, Alberto Deicas, Javier Hurtado, Gaston Burghi, Antonio Martinelli, Ingrid Von Der Osten, Christine Du Maine, Mahuya Bhattacharyya, Susruta Bandyopadhyay, Srishar Yanamala, Palepu Gopal, Samir Sahu, Mohamed Ibrahim, Darshana Rathod, Nisha Mukundan, Arun Dewan, Pravin Amin, Srinivas Samavedam, Bhagyesh Shah, Ganavelu Gurupal, Brajendra Lahkar, Amit K. Mandal, Mrinal Sircar, Supradip Ghosh, Veluchamy Balasubramani, Farhad Kapadia, Sonali Vadi, Kesavan Nair, Swagat Tripathy, Sivakumar Nandakumar, Jeetendra Sharma, Arindam Kar, Simant Jha, Kapil Zirpe, Mayur Patel, Ankur Bhavsar, Devi P. Samaddar, Atul Kulkarni, Madiha Hashmi, Wajid Ali, Syed Nadeem, Kanishka Indraratna, Antoni Margarit, Philipp Urbanek, Joachim Schlieber, Johann Reisinger, Johann Auer, Andreas Hartjes, Andreas Lerche, Thomas Janous, Eveline Kink, Walter Krahulec, Karl Heinz Smolle, Marc Van Der Schueren, Patrick Thibo, Marc Vanhoof, Ibis Ahmet, Philippe Gadisseux, Philippe Dufaye, Olivier Jacobs, Vincent Fraipont, Patrick Biston, Alain Dive, Yves Bouckaert, Eric Gilbert, Benjamin Gressens, Eric Pinck, Vincent Collin, Jean Louis Vincent, Jan J. De Waele, Rocio Rimachi, Dan Gusu, Koen De Decker, Kakisidi Mandianga, Luc Heytens, Xavier Wittebole, Herbert Spapen, Olivier Van Collie, Wout Vandenheede, Peter Rogiers, Piotr Kolodzeike, Mary Kruse, Torben Andersen, Veli Pekka Harjola, Kari Saarinen, Marc Leone, Alain Durocher, Serge Moulront, Alain Lepape, Marie Reine Losser, Philippe Cabaret, Evangelos Kalaitzis, Elie Zogheib, Philippe Charve, Bruno François, Jean Yves Lefrant, Bassam Beilouny, Xavier Forceville, Benoit Misset, Frederic Jacobs, Bernard Floccard, Didier Payen, Alain Wynckel, Vincent Castelain, Alexandre Faure, Pierre Lavagne, Thierry Lepoivre, Mouhamed D. Moussa, Antoine Vieillard-Baron, Michel Durand, Marc Gainnier, Carole Ichai, Stefan Arens, Clemens Hoffmann, Magnus Kaffarnik, Claus Jorg Scharnofske, Ingo Voigt, Claus Peckelsen, Matthias Weber, Jochen Gille, Andreas Lange, Georg Schoser, Armin Sablotzki, Ulrich Jaschinski, Andreas Bluethgen, Frank Vogel, Andreas Tscheu, Thomas Fuchs, Michael Wattenberg, Torsten Helmes, Stefan Scieszka, Matthias Heintz, Samir Sakka, Johannes Kohler, Fritz Fiedler, Matthias Danz, Yasser Sakr, Reimer Riessen, Thomas Kerz, Alexander Kersten, Frank Tacke, Gernot Marx, Thomas Volkert, Axel Schmutz, Axel Nierhaus, Stefan Kluge, Peter Abel, Rolf A. Janosi, Stefan Utzolino, Hendrik Bracht, Susanne Toussaint, Maria Giannakou Peftoulidou, Pavlos Myrianthefs, Apostolos Armaganidis, Christina Routsi, Angela Xini, Eleni Mouloudi, Ioannis Kokoris, George Kyriazopoulos, Sawas Vlachos, Athena Lavrentieva, Panagio Partala, George Nakos, Alma Moller, Sigurjon Stefansson, Joan Barry, Ruth A. O'Leary, Catherine Motherway, Mohammad Faheem, Eimhin Dunne, Maria Donnelly, Torsten Konrad, Eleonora Bonora, Carola Achilli, Sandra Rossi, Giacomo Castiglione, Adriano Peris, Daniela Albanese, Nino Stocchetti, Giuseppe Citerio, Lorella Mozzoni, Erminio Sisillo, Pasquale De Negri, Monica Savioli, Pietro Vecchiarelli, Florin Puflea, Vladimir Stankovic, Giulio Minoja, Silvia Montibeller, Plinio Calligaro, Raffaella Sorrentino, Marco Feri, Massimo Zambon, Elena Colombaroli, Antonino Giarratano, Tommaso Pellis, Carlo Capra, Massimo Antonelli, Antonino Gullo, Cosimo Chelazzi, Antonella De Capraris, Nicolo Patroniti, Massimo Girardis, Frederico Franchi, Giorgio Berlot, Michael Buttigieg, Hubert Ponssen, Julia Ten Cate, Laura Bormans, Satria Husada, Marc Buise, Ben Van Der Hoven, Auke Reidinga, Michael Kuiper, Peter Pickkers, Georg Kluge, Sylvia Den Boer, Jozef Kesecioglu, Henk Van Leeuwen, Hans Flaatten, Skule Mo, Vitor Branco, Fernando Rua, Estevao Lafuente, Marta Sousa, Nuno Catorze, Maria Barros, Luis Pereira, Ana Vintém De Oliveira, Jose Gomes, Isable Gaspar, Maria F. Pereira, Maria Cymbron, Antonio Dias, Eduardo Almeida, Sofia Beirao, Isabel Serra, Rosa Ribeiro, Pedro Povoa, Filomena Faria, Zelia Costa-E-Silva, Jose J. Nóbrega, Fatima Fernandes, Joao Gabriel, Gorazd Voga, Erik Rupnik, Lucka Kosec, Milena Kerin Povšic, Irena Osojnik, Viktorija Tomic, Andreja Sinkovic, Javier González, Elizabeth Zavala, Jesus Pérez Valenzuela, Luis Marina, Pablo Vidal-Cortés, Pilar Posada, Ignacio Martin-Loeches, Noelia Muñoz Guillén, Mercedes Palomar, Jordi Sole-Violan, Antoni Torres, Miguel A. Gonzalez Gallego, Gerardo Aguilar, Raquel Montoiro Allué, Monica Argüeso, Martin Parejo, Manuel Palomo Navarro, Anton Jose, Nicholas Nin, Francisco Alvarez Lerma, Oscar Martinez, Eva Tenza Lozano, Sara Arenal López, Maria J. Perez Granda, Salvador Moreno, Clara Llubia, Carmen De La Fuente Martos, Paloma Gonzalez-Arenas, Noemi Llamas Fernández, Bernard Gil Rueda, Isabel Estruch Pons, Nieves Cruza, Fernando Maroto, Angel Estella, Ana Ferrer, Lisardo Iglesias Fraile, Brigida Quindos, Amaia Quintano, Maria T. Tebar, Pablo Cardinal, Antonio Reyes, Alejandro Rodríguez, Ana Abella, Santiago García Del Valle, Santiago Yus, Emilio Maseda, Jose A. Berezo, Armando Tejero Pedregosa, Clara Laplaza, Ricard Ferrer, Jesus Rico-Feijoo, Marina Rodríguez, Pablo Monedero, Karin Eriksson, Dan Lind, David Chabanel, Hervé Zender, Kuno Heer, Bernd Frankenberger, Stephan Jakob, Alois Haller, Shiju Matthew, Robert Downes, Casiano Barrera Groba, Andrew Johnston, Roseanne Meacher, Rick Keays, Philip Haji-Michael, Chris Tyler, Andrew Ferguson, Simon Jones, David Tyl, Andrew Ball, John Vogel, Malcolm Booth, Paul Downie, Malcolm Watters, Stephen Brett, Marc Garfield, Lynn Everett, Sarah Heenen, Sandeep Dhir, Zoe Beardow, Marthinus Mostert, Steve Brosnan, Nuno Pinto, Stephen Harris, Andy Summors, Andrew Norton, Alastair Rose, Rebecca Appelboam, Omubo Davies, Emma Vickers, Banwari Agarwal, Tamas Szakmany, Stephen Wimbush, Ingeborg Welters, Rupert Pearse, Robin Hollands, Justin Kirk-Bayley, Nick Fletcher, Barbara Bray, David Brealey, Peter Alexander, Steven Henderson, Chris Hargreaves, Heather Black, Kiran Gowda

Research output: Contribution to journalArticle

Abstract

Background: Urine output is widely used as one of the criteria for the diagnosis and staging of acute renal failure, but few studies have specifically assessed the role of oliguria as a marker of acute renal failure or outcomes in general intensive care unit (ICU) patients. Using a large multinational database, we therefore evaluated the occurrence of oliguria (defined as a urine output < 0.5 ml/kg/h) in acutely ill patients and its association with the need for renal replacement therapy (RRT) and outcome. Methods: International observational study. All adult (> 16 years) patients in the ICON audit who had a urine output measurement on the day of admission were included. To investigate the association between oliguria and mortality, we used a multilevel analysis. Results: Of the 8292 patients included, 2050 (24.7%) were oliguric during the first 24 h of admission. Patients with oliguria on admission who had at least one additional 24-h urine output recorded during their ICU stay (n = 1349) were divided into three groups: transient - oliguria resolved within 48 h after the admission day (n = 390 [28.9%]), prolonged - oliguria resolved > 48 h after the admission day (n = 141 [10.5%]), and permanent - oliguria persisting for the whole ICU stay or again present at the end of the ICU stay (n = 818 [60.6%]). ICU and hospital mortality rates were higher in patients with oliguria than in those without, except for patients with transient oliguria who had significantly lower mortality rates than non-oliguric patients. In multilevel analysis, the need for RRT was associated with a significantly higher risk of death (OR = 1.51 [95% CI 1.19-1.91], p = 0.001), but the presence of oliguria on admission was not (OR = 1.14 [95% CI 0.97-1.34], p = 0.103). Conclusions: Oliguria is common in ICU patients and may have a relatively benign nature if only transient. The duration of oliguria and need for RRT are associated with worse outcome.

Original languageEnglish
Article number171
JournalCritical Care
Volume24
Issue number1
DOIs
Publication statusPublished - 23-04-2020

All Science Journal Classification (ASJC) codes

  • Critical Care and Intensive Care Medicine

Fingerprint Dive into the research topics of 'The clinical relevance of oliguria in the critically ill patient: Analysis of a large observational database'. Together they form a unique fingerprint.

  • Cite this

    Vincent, J. L., Ferguson, A., Pickkers, P., Jakob, S. M., Jaschinski, U., Almekhlafi, G. A., Leone, M., Mokhtari, M., Fontes, L. E., Bauer, P. R., Sakr, Y., Tomas, E., Bibonge, E. A., Charra, B., Faroudy, M., Doedens, L., Farina, Z., Adler, D., Balkema, C., ... Gowda, K. (2020). The clinical relevance of oliguria in the critically ill patient: Analysis of a large observational database. Critical Care, 24(1), [171]. https://doi.org/10.1186/s13054-020-02858-x