The clinical relevance of plasma CD147/basigin in biopsy-proven kidney diseases

Yoshiko Mori, Tomohiro Masuda, Tomoki Kosugi, Tomoki Yoshioka, Mayuko Hori, Hiroshi Nagaya, Kayaho Maeda, Yuka Sato, Hiroshi Kojima, Noritoshi Kato, Takuji Ishimoto, Takayuki Katsuno, Yukio Yuzawa, Kenji Kadomatsu, Shoichi Maruyama

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Precise understanding of kidney disease activity is needed to design therapeutic strategies. CD147/basigin is involved in the pathogenesis of acute kidney injury and renal fibrosis through inflammatory cell infiltration. The present study examined the clinical relevance of CD147 in biopsy-proven kidney diseases that lead to the progression of chronic kidney disease. Methods: Kidney biopsy specimens and plasma and urine samples were obtained from patients with kidney diseases, including IgA nephropathy (IgAN), Henoch–Schönlein purpura nephritis (HSPN), diabetic kidney disease (DKD), focal segmental glomerulosclerosis (FSGS), and membranous nephropathy (MN), who underwent renal biopsy between 2011 and 2014. Plasma and urinary CD147 levels were measured and evaluated for their ability to reflect histological features. Disease activity of IgAN tissues was evaluated according to the Oxford classification and the Japanese histological grading system. Results: In biopsy tissues, CD147 induction was detected in injured lesions representing renal inflammation. Plasma CD147 values correlated with eGFR in patients with inflammation-related kidney diseases such as IgAN, HSPN, and DKD. Particularly in IgAN patients, plasma CD147 levels were correlated with injured regions comprising more than 50% of glomeruli or with tubular atrophy/interstitial injury in biopsy tissues. Proteinuria showed a closer correlation with urinary values of CD147 and L-FABP. Of note, plasma and urinary CD147 levels showed a strong correlation with eGFR or proteinuria, respectively, only in DKD patients. Conclusion: Evaluation of plasma and urinary CD147 levels might provide key insights for the understanding of the activity of various kidney diseases.

Original languageEnglish
Pages (from-to)815-824
Number of pages10
JournalClinical and Experimental Nephrology
Volume22
Issue number4
DOIs
Publication statusPublished - 01-08-2018

Fingerprint

CD147 Antigens
Kidney Diseases
Biopsy
Immunoglobulin A
Diabetic Nephropathies
Kidney
Purpura
Nephritis
Proteinuria
Inflammation
Focal Segmental Glomerulosclerosis
Membranous Glomerulonephritis
Chronic Renal Insufficiency
Acute Kidney Injury
Atrophy
Fibrosis
Urine
Wounds and Injuries

All Science Journal Classification (ASJC) codes

  • Physiology
  • Nephrology
  • Physiology (medical)

Cite this

Mori, Y., Masuda, T., Kosugi, T., Yoshioka, T., Hori, M., Nagaya, H., ... Maruyama, S. (2018). The clinical relevance of plasma CD147/basigin in biopsy-proven kidney diseases. Clinical and Experimental Nephrology, 22(4), 815-824. https://doi.org/10.1007/s10157-017-1518-2
Mori, Yoshiko ; Masuda, Tomohiro ; Kosugi, Tomoki ; Yoshioka, Tomoki ; Hori, Mayuko ; Nagaya, Hiroshi ; Maeda, Kayaho ; Sato, Yuka ; Kojima, Hiroshi ; Kato, Noritoshi ; Ishimoto, Takuji ; Katsuno, Takayuki ; Yuzawa, Yukio ; Kadomatsu, Kenji ; Maruyama, Shoichi. / The clinical relevance of plasma CD147/basigin in biopsy-proven kidney diseases. In: Clinical and Experimental Nephrology. 2018 ; Vol. 22, No. 4. pp. 815-824.
@article{6043aed1f8164996a5392e0c71aeabc1,
title = "The clinical relevance of plasma CD147/basigin in biopsy-proven kidney diseases",
abstract = "Background: Precise understanding of kidney disease activity is needed to design therapeutic strategies. CD147/basigin is involved in the pathogenesis of acute kidney injury and renal fibrosis through inflammatory cell infiltration. The present study examined the clinical relevance of CD147 in biopsy-proven kidney diseases that lead to the progression of chronic kidney disease. Methods: Kidney biopsy specimens and plasma and urine samples were obtained from patients with kidney diseases, including IgA nephropathy (IgAN), Henoch–Sch{\"o}nlein purpura nephritis (HSPN), diabetic kidney disease (DKD), focal segmental glomerulosclerosis (FSGS), and membranous nephropathy (MN), who underwent renal biopsy between 2011 and 2014. Plasma and urinary CD147 levels were measured and evaluated for their ability to reflect histological features. Disease activity of IgAN tissues was evaluated according to the Oxford classification and the Japanese histological grading system. Results: In biopsy tissues, CD147 induction was detected in injured lesions representing renal inflammation. Plasma CD147 values correlated with eGFR in patients with inflammation-related kidney diseases such as IgAN, HSPN, and DKD. Particularly in IgAN patients, plasma CD147 levels were correlated with injured regions comprising more than 50{\%} of glomeruli or with tubular atrophy/interstitial injury in biopsy tissues. Proteinuria showed a closer correlation with urinary values of CD147 and L-FABP. Of note, plasma and urinary CD147 levels showed a strong correlation with eGFR or proteinuria, respectively, only in DKD patients. Conclusion: Evaluation of plasma and urinary CD147 levels might provide key insights for the understanding of the activity of various kidney diseases.",
author = "Yoshiko Mori and Tomohiro Masuda and Tomoki Kosugi and Tomoki Yoshioka and Mayuko Hori and Hiroshi Nagaya and Kayaho Maeda and Yuka Sato and Hiroshi Kojima and Noritoshi Kato and Takuji Ishimoto and Takayuki Katsuno and Yukio Yuzawa and Kenji Kadomatsu and Shoichi Maruyama",
year = "2018",
month = "8",
day = "1",
doi = "10.1007/s10157-017-1518-2",
language = "English",
volume = "22",
pages = "815--824",
journal = "Clinical and Experimental Nephrology",
issn = "1342-1751",
publisher = "Springer Japan",
number = "4",

}

Mori, Y, Masuda, T, Kosugi, T, Yoshioka, T, Hori, M, Nagaya, H, Maeda, K, Sato, Y, Kojima, H, Kato, N, Ishimoto, T, Katsuno, T, Yuzawa, Y, Kadomatsu, K & Maruyama, S 2018, 'The clinical relevance of plasma CD147/basigin in biopsy-proven kidney diseases', Clinical and Experimental Nephrology, vol. 22, no. 4, pp. 815-824. https://doi.org/10.1007/s10157-017-1518-2

The clinical relevance of plasma CD147/basigin in biopsy-proven kidney diseases. / Mori, Yoshiko; Masuda, Tomohiro; Kosugi, Tomoki; Yoshioka, Tomoki; Hori, Mayuko; Nagaya, Hiroshi; Maeda, Kayaho; Sato, Yuka; Kojima, Hiroshi; Kato, Noritoshi; Ishimoto, Takuji; Katsuno, Takayuki; Yuzawa, Yukio; Kadomatsu, Kenji; Maruyama, Shoichi.

In: Clinical and Experimental Nephrology, Vol. 22, No. 4, 01.08.2018, p. 815-824.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The clinical relevance of plasma CD147/basigin in biopsy-proven kidney diseases

AU - Mori, Yoshiko

AU - Masuda, Tomohiro

AU - Kosugi, Tomoki

AU - Yoshioka, Tomoki

AU - Hori, Mayuko

AU - Nagaya, Hiroshi

AU - Maeda, Kayaho

AU - Sato, Yuka

AU - Kojima, Hiroshi

AU - Kato, Noritoshi

AU - Ishimoto, Takuji

AU - Katsuno, Takayuki

AU - Yuzawa, Yukio

AU - Kadomatsu, Kenji

AU - Maruyama, Shoichi

PY - 2018/8/1

Y1 - 2018/8/1

N2 - Background: Precise understanding of kidney disease activity is needed to design therapeutic strategies. CD147/basigin is involved in the pathogenesis of acute kidney injury and renal fibrosis through inflammatory cell infiltration. The present study examined the clinical relevance of CD147 in biopsy-proven kidney diseases that lead to the progression of chronic kidney disease. Methods: Kidney biopsy specimens and plasma and urine samples were obtained from patients with kidney diseases, including IgA nephropathy (IgAN), Henoch–Schönlein purpura nephritis (HSPN), diabetic kidney disease (DKD), focal segmental glomerulosclerosis (FSGS), and membranous nephropathy (MN), who underwent renal biopsy between 2011 and 2014. Plasma and urinary CD147 levels were measured and evaluated for their ability to reflect histological features. Disease activity of IgAN tissues was evaluated according to the Oxford classification and the Japanese histological grading system. Results: In biopsy tissues, CD147 induction was detected in injured lesions representing renal inflammation. Plasma CD147 values correlated with eGFR in patients with inflammation-related kidney diseases such as IgAN, HSPN, and DKD. Particularly in IgAN patients, plasma CD147 levels were correlated with injured regions comprising more than 50% of glomeruli or with tubular atrophy/interstitial injury in biopsy tissues. Proteinuria showed a closer correlation with urinary values of CD147 and L-FABP. Of note, plasma and urinary CD147 levels showed a strong correlation with eGFR or proteinuria, respectively, only in DKD patients. Conclusion: Evaluation of plasma and urinary CD147 levels might provide key insights for the understanding of the activity of various kidney diseases.

AB - Background: Precise understanding of kidney disease activity is needed to design therapeutic strategies. CD147/basigin is involved in the pathogenesis of acute kidney injury and renal fibrosis through inflammatory cell infiltration. The present study examined the clinical relevance of CD147 in biopsy-proven kidney diseases that lead to the progression of chronic kidney disease. Methods: Kidney biopsy specimens and plasma and urine samples were obtained from patients with kidney diseases, including IgA nephropathy (IgAN), Henoch–Schönlein purpura nephritis (HSPN), diabetic kidney disease (DKD), focal segmental glomerulosclerosis (FSGS), and membranous nephropathy (MN), who underwent renal biopsy between 2011 and 2014. Plasma and urinary CD147 levels were measured and evaluated for their ability to reflect histological features. Disease activity of IgAN tissues was evaluated according to the Oxford classification and the Japanese histological grading system. Results: In biopsy tissues, CD147 induction was detected in injured lesions representing renal inflammation. Plasma CD147 values correlated with eGFR in patients with inflammation-related kidney diseases such as IgAN, HSPN, and DKD. Particularly in IgAN patients, plasma CD147 levels were correlated with injured regions comprising more than 50% of glomeruli or with tubular atrophy/interstitial injury in biopsy tissues. Proteinuria showed a closer correlation with urinary values of CD147 and L-FABP. Of note, plasma and urinary CD147 levels showed a strong correlation with eGFR or proteinuria, respectively, only in DKD patients. Conclusion: Evaluation of plasma and urinary CD147 levels might provide key insights for the understanding of the activity of various kidney diseases.

UR - http://www.scopus.com/inward/record.url?scp=85037740987&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85037740987&partnerID=8YFLogxK

U2 - 10.1007/s10157-017-1518-2

DO - 10.1007/s10157-017-1518-2

M3 - Article

C2 - 29234893

AN - SCOPUS:85037740987

VL - 22

SP - 815

EP - 824

JO - Clinical and Experimental Nephrology

JF - Clinical and Experimental Nephrology

SN - 1342-1751

IS - 4

ER -