The CLOCK gene and mood disorders: A case-control study and meta-analysis

Taro Kishi, Reiji Yoshimura, Yasuhisa Fukuo, Tsuyoshi Kitajima, Tomo Okochi, Shinji Matsunaga, Toshiya Inada, Hiroshi Kunugi, Tadafumi Kato, Takeo Yoshikawa, Hiroshi Ujike, Wakako Umene-Nakano, Jun Nakamura, Norio Ozaki, Alessandro Serretti, Christoph U. Correll, Nakao Iwata

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Abstract

The clock gene (CLOCK) is considered to be a good candidate gene for the pathophysiology of mood disorders, including bipolar disorder (BP) and major depressive disorder (MDD). rs1801260 (T3111C) has been detected at position 3111 in the CLOCK mRNA 3' untranslated region, and was reported to be associated with a substantial delay in preferred timing for activity and sleep in a human study. As for function, rs1801260 has been speculated to affect mRNA. Therefore, the authors investigated the association between the three tagging single-nucleotide polymorphisms (SNPs) (rs3736544, rs1801260, and rs3749474) in CLOCK and risk of BP (n=867) and MDD (n=139) compared to controls (n=889) in the Japanese population. In addition, we also performed an updated meta-analysis of nine published, genetic association studies investigating the relationship between rs1801260 and mood disorder risk, comprising 3321 mood disorders cases and 3574 controls. We did not detect any associations between tagging SNPs in CLOCK and BP or MDD in the allele, genotype, or haplotype analysis (global pBP=.605 and global pMDD=.211). Moreover, rs1801260 was also not associated with BP, MDD, or any mood disorders in the meta-analysis. In conclusion, these data suggest that CLOCK does not play a major role in the pathophysiology of mood disorders.

Original languageEnglish
Pages (from-to)825-833
Number of pages9
JournalChronobiology International
Volume28
Issue number9
DOIs
Publication statusPublished - 01-11-2011

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All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

Cite this

Kishi, T., Yoshimura, R., Fukuo, Y., Kitajima, T., Okochi, T., Matsunaga, S., Inada, T., Kunugi, H., Kato, T., Yoshikawa, T., Ujike, H., Umene-Nakano, W., Nakamura, J., Ozaki, N., Serretti, A., Correll, C. U., & Iwata, N. (2011). The CLOCK gene and mood disorders: A case-control study and meta-analysis. Chronobiology International, 28(9), 825-833. https://doi.org/10.3109/07420528.2011.609951