TY - JOUR
T1 - The CLOCK gene and mood disorders
T2 - A case-control study and meta-analysis
AU - Kishi, Taro
AU - Yoshimura, Reiji
AU - Fukuo, Yasuhisa
AU - Kitajima, Tsuyoshi
AU - Okochi, Tomo
AU - Matsunaga, Shinji
AU - Inada, Toshiya
AU - Kunugi, Hiroshi
AU - Kato, Tadafumi
AU - Yoshikawa, Takeo
AU - Ujike, Hiroshi
AU - Umene-Nakano, Wakako
AU - Nakamura, Jun
AU - Ozaki, Norio
AU - Serretti, Alessandro
AU - Correll, Christoph U.
AU - Iwata, Nakao
N1 - Funding Information:
This work was supported in part by research grants from the Japan Ministry of Education, Culture, Sports, Science and Technology, the Ministry of Health, Labor and Welfare, and the Health Sciences Foundation (Research on Health Sciences focusing on Drug Innovation). Dr. Kishi is a postdoctoral fellow for research abroad, and is additionally supported by the Japan Research Foundation for Clinical Pharmacology and the Ministry of Education.
PY - 2011/11
Y1 - 2011/11
N2 - The clock gene (CLOCK) is considered to be a good candidate gene for the pathophysiology of mood disorders, including bipolar disorder (BP) and major depressive disorder (MDD). rs1801260 (T3111C) has been detected at position 3111 in the CLOCK mRNA 3' untranslated region, and was reported to be associated with a substantial delay in preferred timing for activity and sleep in a human study. As for function, rs1801260 has been speculated to affect mRNA. Therefore, the authors investigated the association between the three tagging single-nucleotide polymorphisms (SNPs) (rs3736544, rs1801260, and rs3749474) in CLOCK and risk of BP (n=867) and MDD (n=139) compared to controls (n=889) in the Japanese population. In addition, we also performed an updated meta-analysis of nine published, genetic association studies investigating the relationship between rs1801260 and mood disorder risk, comprising 3321 mood disorders cases and 3574 controls. We did not detect any associations between tagging SNPs in CLOCK and BP or MDD in the allele, genotype, or haplotype analysis (global pBP=.605 and global pMDD=.211). Moreover, rs1801260 was also not associated with BP, MDD, or any mood disorders in the meta-analysis. In conclusion, these data suggest that CLOCK does not play a major role in the pathophysiology of mood disorders.
AB - The clock gene (CLOCK) is considered to be a good candidate gene for the pathophysiology of mood disorders, including bipolar disorder (BP) and major depressive disorder (MDD). rs1801260 (T3111C) has been detected at position 3111 in the CLOCK mRNA 3' untranslated region, and was reported to be associated with a substantial delay in preferred timing for activity and sleep in a human study. As for function, rs1801260 has been speculated to affect mRNA. Therefore, the authors investigated the association between the three tagging single-nucleotide polymorphisms (SNPs) (rs3736544, rs1801260, and rs3749474) in CLOCK and risk of BP (n=867) and MDD (n=139) compared to controls (n=889) in the Japanese population. In addition, we also performed an updated meta-analysis of nine published, genetic association studies investigating the relationship between rs1801260 and mood disorder risk, comprising 3321 mood disorders cases and 3574 controls. We did not detect any associations between tagging SNPs in CLOCK and BP or MDD in the allele, genotype, or haplotype analysis (global pBP=.605 and global pMDD=.211). Moreover, rs1801260 was also not associated with BP, MDD, or any mood disorders in the meta-analysis. In conclusion, these data suggest that CLOCK does not play a major role in the pathophysiology of mood disorders.
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U2 - 10.3109/07420528.2011.609951
DO - 10.3109/07420528.2011.609951
M3 - Article
C2 - 22080789
AN - SCOPUS:81255124349
SN - 0742-0528
VL - 28
SP - 825
EP - 833
JO - Chronobiology International
JF - Chronobiology International
IS - 9
ER -