The coexistence of systemic sclerosis and rheumatoid arthritis in five patients

Terumi Horiki, Junko Moriuchi, Masatoshi Takaya, Mitsuaki Uchiyama, Yuichi Hoshina, Kenichi Inada, Hidetoshi Inoko, Kmiyoshi Tsuji, Yukinobu Ichikawa

Research output: Contribution to journalArticlepeer-review

46 Citations (Scopus)


To elucidate the clinical characteristics and pathogenesis of scleroderma-rheumatoid arthritis (SSc-RA) overlap syndrome, we analyzed the clinical features of 5 patients with SSc-RA overlap. Their HLA phenotypes and genotypes were also determined. Generalized skin sclerosis, severe seropositive polyarthritis, pulmonary fibrosis, anti-topoisomerase I antibodies, and HLA-DR4,53;DQA1*0301;DQB1*04 haplotype were observed in all of the patients. Similar clinical features were recognized in most of the 10 cases reported previously. Our case studies indicate that SSc-RA overlap may be a distinct entity.

Original languageEnglish
Pages (from-to)152-156
Number of pages5
JournalArthritis and Rheumatism
Issue number1
Publication statusPublished - 01-1996
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)


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