The coexistence of systemic sclerosis and rheumatoid arthritis in five patients

Terumi Horiki; Junko Moriuchi; Masatoshi Takaya; Mitsuaki Uchiyama; Yuichi Hoshina; Kenichi Inada; Hidetoshi Inoko; Kmiyoshi Tsuji; Yukinobu Ichikawa

doi:10.1002/art.1780390121

The coexistence of systemic sclerosis and rheumatoid arthritis in five patients

Terumi Horiki
, Junko Moriuchi
, Masatoshi Takaya
, Mitsuaki Uchiyama
, Yuichi Hoshina
, Kenichi Inada
, Hidetoshi Inoko
, Kmiyoshi Tsuji
, Yukinobu Ichikawa

Research output: Contribution to journal › Article › peer-review

47 Citations (Scopus)

Abstract

To elucidate the clinical characteristics and pathogenesis of scleroderma-rheumatoid arthritis (SSc-RA) overlap syndrome, we analyzed the clinical features of 5 patients with SSc-RA overlap. Their HLA phenotypes and genotypes were also determined. Generalized skin sclerosis, severe seropositive polyarthritis, pulmonary fibrosis, anti-topoisomerase I antibodies, and HLA-DR4,53;DQA1*0301;DQB1*04 haplotype were observed in all of the patients. Similar clinical features were recognized in most of the 10 cases reported previously. Our case studies indicate that SSc-RA overlap may be a distinct entity.

Original language	English
Pages (from-to)	152-156
Number of pages	5
Journal	Arthritis and Rheumatism
Volume	39
Issue number	1
DOIs	https://doi.org/10.1002/art.1780390121
Publication status	Published - 01-1996
Externally published	Yes

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Rheumatology
Immunology
Pharmacology (medical)

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10.1002/art.1780390121

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abstract = "To elucidate the clinical characteristics and pathogenesis of scleroderma-rheumatoid arthritis (SSc-RA) overlap syndrome, we analyzed the clinical features of 5 patients with SSc-RA overlap. Their HLA phenotypes and genotypes were also determined. Generalized skin sclerosis, severe seropositive polyarthritis, pulmonary fibrosis, anti-topoisomerase I antibodies, and HLA-DR4,53;DQA1*0301;DQB1*04 haplotype were observed in all of the patients. Similar clinical features were recognized in most of the 10 cases reported previously. Our case studies indicate that SSc-RA overlap may be a distinct entity.",

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AU - Horiki, Terumi

AU - Moriuchi, Junko

AU - Takaya, Masatoshi

AU - Uchiyama, Mitsuaki

AU - Hoshina, Yuichi

AU - Inada, Kenichi

AU - Inoko, Hidetoshi

AU - Tsuji, Kmiyoshi

AU - Ichikawa, Yukinobu

PY - 1996/1

Y1 - 1996/1

N2 - To elucidate the clinical characteristics and pathogenesis of scleroderma-rheumatoid arthritis (SSc-RA) overlap syndrome, we analyzed the clinical features of 5 patients with SSc-RA overlap. Their HLA phenotypes and genotypes were also determined. Generalized skin sclerosis, severe seropositive polyarthritis, pulmonary fibrosis, anti-topoisomerase I antibodies, and HLA-DR4,53;DQA1*0301;DQB1*04 haplotype were observed in all of the patients. Similar clinical features were recognized in most of the 10 cases reported previously. Our case studies indicate that SSc-RA overlap may be a distinct entity.

AB - To elucidate the clinical characteristics and pathogenesis of scleroderma-rheumatoid arthritis (SSc-RA) overlap syndrome, we analyzed the clinical features of 5 patients with SSc-RA overlap. Their HLA phenotypes and genotypes were also determined. Generalized skin sclerosis, severe seropositive polyarthritis, pulmonary fibrosis, anti-topoisomerase I antibodies, and HLA-DR4,53;DQA1*0301;DQB1*04 haplotype were observed in all of the patients. Similar clinical features were recognized in most of the 10 cases reported previously. Our case studies indicate that SSc-RA overlap may be a distinct entity.

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The coexistence of systemic sclerosis and rheumatoid arthritis in five patients

Abstract

All Science Journal Classification (ASJC) codes

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