The combination of preoperative platelet count and neutrophil lymphocyte ratio as a prognostic indicator in localized renal cell carcinoma

Takuya Tsujino, Kazumasa Komura, Atsushi Ichihashi, Takeshi Tsutsumi, Tomohisa Matsunaga, Yuki Yoshikawa, Ryoichi Maenosono, Kyohei Okita, Tomoaki Takai, Rintaro Oide, Koichiro Minami, Hirofumi Uehara, Kohei Taniguchi, Hajime Hirano, Hayahito Nomi, Naokazu Ibuki, Kiyoshi Takahara, Teruo Inamoto, Haruhito Azuma

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Introduction: The combination of platelet count and neutrophil to lymphocyte ratio (COP-NLR) has been shown to provide prognostic information in several cancers, whereas its prognostic value in renal cell carcinoma (RCC) has not been reported. The objective of the present study was to examine the preoperative prognostic value of the COP-NLR in patients with localized RCC undergoing nephrectomy. Material and Methods: The record of 268 patients, who underwent nephrectomy due to a diagnosis of RCC at our institute was analyzed in the study. The cut-off value of platelet count and NLR were defined by receive operating characteristic (ROC) analysis and the areas under the curve (AUC). Patients with both an increased platelet count (> 310×109/l) and an elevated NLR (> 3.85) were assigned to the score 2, and patients with one or neither of these indicators were assigned to the score 1 or 0, respectively. The impact of the COP-NLR and other clinicopathological characteristics on overall survival (OS) and recurrence-free survival (RFS) were evaluated using the univariate and multivariate Cox regression analysis. Result: The median follow-up duration after surgical resection was 60 months. Multivariate analysis using the 10 clinicopathological findings selected by univariate analyses demonstrated that the preoperative COP-NLR was an independent prognostic factor for OS (HR: 2.32, 95%CI: 1.22 to 4.26, p=0.011) and RFS (HR: 1.91, 95%CI: 1.02 to 3.53, p=0.044). Conclusion: The findings of the current study suggested that the preoperative COP-NLR is an independent prognostic indicator of OS and RFS for patients with localized RCC.

Original languageEnglish
Pages (from-to)110311-110325
Number of pages15
JournalOncotarget
Volume8
Issue number66
DOIs
Publication statusPublished - 01-01-2017

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Platelet Count
Renal Cell Carcinoma
Neutrophils
Lymphocytes
Survival
Nephrectomy
Recurrence
Area Under Curve
Multivariate Analysis
Regression Analysis
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology

Cite this

Tsujino, T., Komura, K., Ichihashi, A., Tsutsumi, T., Matsunaga, T., Yoshikawa, Y., ... Azuma, H. (2017). The combination of preoperative platelet count and neutrophil lymphocyte ratio as a prognostic indicator in localized renal cell carcinoma. Oncotarget, 8(66), 110311-110325. https://doi.org/10.18632/oncotarget.22688
Tsujino, Takuya ; Komura, Kazumasa ; Ichihashi, Atsushi ; Tsutsumi, Takeshi ; Matsunaga, Tomohisa ; Yoshikawa, Yuki ; Maenosono, Ryoichi ; Okita, Kyohei ; Takai, Tomoaki ; Oide, Rintaro ; Minami, Koichiro ; Uehara, Hirofumi ; Taniguchi, Kohei ; Hirano, Hajime ; Nomi, Hayahito ; Ibuki, Naokazu ; Takahara, Kiyoshi ; Inamoto, Teruo ; Azuma, Haruhito. / The combination of preoperative platelet count and neutrophil lymphocyte ratio as a prognostic indicator in localized renal cell carcinoma. In: Oncotarget. 2017 ; Vol. 8, No. 66. pp. 110311-110325.
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abstract = "Introduction: The combination of platelet count and neutrophil to lymphocyte ratio (COP-NLR) has been shown to provide prognostic information in several cancers, whereas its prognostic value in renal cell carcinoma (RCC) has not been reported. The objective of the present study was to examine the preoperative prognostic value of the COP-NLR in patients with localized RCC undergoing nephrectomy. Material and Methods: The record of 268 patients, who underwent nephrectomy due to a diagnosis of RCC at our institute was analyzed in the study. The cut-off value of platelet count and NLR were defined by receive operating characteristic (ROC) analysis and the areas under the curve (AUC). Patients with both an increased platelet count (> 310×109/l) and an elevated NLR (> 3.85) were assigned to the score 2, and patients with one or neither of these indicators were assigned to the score 1 or 0, respectively. The impact of the COP-NLR and other clinicopathological characteristics on overall survival (OS) and recurrence-free survival (RFS) were evaluated using the univariate and multivariate Cox regression analysis. Result: The median follow-up duration after surgical resection was 60 months. Multivariate analysis using the 10 clinicopathological findings selected by univariate analyses demonstrated that the preoperative COP-NLR was an independent prognostic factor for OS (HR: 2.32, 95{\%}CI: 1.22 to 4.26, p=0.011) and RFS (HR: 1.91, 95{\%}CI: 1.02 to 3.53, p=0.044). Conclusion: The findings of the current study suggested that the preoperative COP-NLR is an independent prognostic indicator of OS and RFS for patients with localized RCC.",
author = "Takuya Tsujino and Kazumasa Komura and Atsushi Ichihashi and Takeshi Tsutsumi and Tomohisa Matsunaga and Yuki Yoshikawa and Ryoichi Maenosono and Kyohei Okita and Tomoaki Takai and Rintaro Oide and Koichiro Minami and Hirofumi Uehara and Kohei Taniguchi and Hajime Hirano and Hayahito Nomi and Naokazu Ibuki and Kiyoshi Takahara and Teruo Inamoto and Haruhito Azuma",
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Tsujino, T, Komura, K, Ichihashi, A, Tsutsumi, T, Matsunaga, T, Yoshikawa, Y, Maenosono, R, Okita, K, Takai, T, Oide, R, Minami, K, Uehara, H, Taniguchi, K, Hirano, H, Nomi, H, Ibuki, N, Takahara, K, Inamoto, T & Azuma, H 2017, 'The combination of preoperative platelet count and neutrophil lymphocyte ratio as a prognostic indicator in localized renal cell carcinoma', Oncotarget, vol. 8, no. 66, pp. 110311-110325. https://doi.org/10.18632/oncotarget.22688

The combination of preoperative platelet count and neutrophil lymphocyte ratio as a prognostic indicator in localized renal cell carcinoma. / Tsujino, Takuya; Komura, Kazumasa; Ichihashi, Atsushi; Tsutsumi, Takeshi; Matsunaga, Tomohisa; Yoshikawa, Yuki; Maenosono, Ryoichi; Okita, Kyohei; Takai, Tomoaki; Oide, Rintaro; Minami, Koichiro; Uehara, Hirofumi; Taniguchi, Kohei; Hirano, Hajime; Nomi, Hayahito; Ibuki, Naokazu; Takahara, Kiyoshi; Inamoto, Teruo; Azuma, Haruhito.

In: Oncotarget, Vol. 8, No. 66, 01.01.2017, p. 110311-110325.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The combination of preoperative platelet count and neutrophil lymphocyte ratio as a prognostic indicator in localized renal cell carcinoma

AU - Tsujino, Takuya

AU - Komura, Kazumasa

AU - Ichihashi, Atsushi

AU - Tsutsumi, Takeshi

AU - Matsunaga, Tomohisa

AU - Yoshikawa, Yuki

AU - Maenosono, Ryoichi

AU - Okita, Kyohei

AU - Takai, Tomoaki

AU - Oide, Rintaro

AU - Minami, Koichiro

AU - Uehara, Hirofumi

AU - Taniguchi, Kohei

AU - Hirano, Hajime

AU - Nomi, Hayahito

AU - Ibuki, Naokazu

AU - Takahara, Kiyoshi

AU - Inamoto, Teruo

AU - Azuma, Haruhito

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Introduction: The combination of platelet count and neutrophil to lymphocyte ratio (COP-NLR) has been shown to provide prognostic information in several cancers, whereas its prognostic value in renal cell carcinoma (RCC) has not been reported. The objective of the present study was to examine the preoperative prognostic value of the COP-NLR in patients with localized RCC undergoing nephrectomy. Material and Methods: The record of 268 patients, who underwent nephrectomy due to a diagnosis of RCC at our institute was analyzed in the study. The cut-off value of platelet count and NLR were defined by receive operating characteristic (ROC) analysis and the areas under the curve (AUC). Patients with both an increased platelet count (> 310×109/l) and an elevated NLR (> 3.85) were assigned to the score 2, and patients with one or neither of these indicators were assigned to the score 1 or 0, respectively. The impact of the COP-NLR and other clinicopathological characteristics on overall survival (OS) and recurrence-free survival (RFS) were evaluated using the univariate and multivariate Cox regression analysis. Result: The median follow-up duration after surgical resection was 60 months. Multivariate analysis using the 10 clinicopathological findings selected by univariate analyses demonstrated that the preoperative COP-NLR was an independent prognostic factor for OS (HR: 2.32, 95%CI: 1.22 to 4.26, p=0.011) and RFS (HR: 1.91, 95%CI: 1.02 to 3.53, p=0.044). Conclusion: The findings of the current study suggested that the preoperative COP-NLR is an independent prognostic indicator of OS and RFS for patients with localized RCC.

AB - Introduction: The combination of platelet count and neutrophil to lymphocyte ratio (COP-NLR) has been shown to provide prognostic information in several cancers, whereas its prognostic value in renal cell carcinoma (RCC) has not been reported. The objective of the present study was to examine the preoperative prognostic value of the COP-NLR in patients with localized RCC undergoing nephrectomy. Material and Methods: The record of 268 patients, who underwent nephrectomy due to a diagnosis of RCC at our institute was analyzed in the study. The cut-off value of platelet count and NLR were defined by receive operating characteristic (ROC) analysis and the areas under the curve (AUC). Patients with both an increased platelet count (> 310×109/l) and an elevated NLR (> 3.85) were assigned to the score 2, and patients with one or neither of these indicators were assigned to the score 1 or 0, respectively. The impact of the COP-NLR and other clinicopathological characteristics on overall survival (OS) and recurrence-free survival (RFS) were evaluated using the univariate and multivariate Cox regression analysis. Result: The median follow-up duration after surgical resection was 60 months. Multivariate analysis using the 10 clinicopathological findings selected by univariate analyses demonstrated that the preoperative COP-NLR was an independent prognostic factor for OS (HR: 2.32, 95%CI: 1.22 to 4.26, p=0.011) and RFS (HR: 1.91, 95%CI: 1.02 to 3.53, p=0.044). Conclusion: The findings of the current study suggested that the preoperative COP-NLR is an independent prognostic indicator of OS and RFS for patients with localized RCC.

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DO - 10.18632/oncotarget.22688

M3 - Article

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SP - 110311

EP - 110325

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SN - 1949-2553

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