The common myelolymphoid progenitor: A key intermediate stage in hemopoiesis generating T and B cells

Min Lu, Hiroshi Kawamoto, Yoshihiro Katsube, Tomokatsu Ikawa, Yoshimoto Katsura

Research output: Contribution to journalArticlepeer-review

68 Citations (Scopus)

Abstract

We have previously shown that the common progenitors for myeloid, T, and B cell lineages are enriched in the earliest population of murine fetal liver. However, it remained unclear whether such multipotent progenitors represent the pluripotent progenitors capable of generating all hemopoietic cells or they also comprise progenitors restricted to myeloid, T, and B cell lineages. To address this issue, we have developed a new clonal assay covering myeloid, erythroid, T, and B cell lineages, and using this assay the developmental potential of individual cells in subpopulations of lineage marker-negative (Lin-) c-kit+ murine fetal liver cells was investigated. We identified the progenitor generating myeloid, T, and B cells, but not erythroid cells in the Sca-1high subpopulation of Linc-kit+ cells that can thus be designated as the common myelolymphoid progenitor (CMLP). Common myeloerythroid progenitors were also detected. These findings strongly suggest that the first branching point in fetal hemopoiesis is between the CMLP and common myeloerythroid progenitors. T and B cell progenitors may be derived from the CMLP through the previously identified myeloid/T and myeloid/B bipotent stages, respectively.

Original languageEnglish
Pages (from-to)3519-3525
Number of pages7
JournalJournal of Immunology
Volume169
Issue number7
DOIs
Publication statusPublished - 01-10-2002
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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