The comparison of parotid gland carcinoma and submandibular gland carcinoma―Results of a multi institutional retrospective study

Koichiro Yamada, Keigo Honda, Shinzo Tanaka, Hisanobu Tamaki, Tsuyoshi Kojima, Shogo Shinohara, Shinji Takebayashi, Toshiki Maetani, Ryo Asato, Ichiro Tateya, Morimasa Kitamura, Masanobu Mizuta, Yoshiharu Kitani, Koji Ushiro, Kazuyuki Ichimaru, Yohei Kumabe, Koichi Omori

Research output: Contribution to journalArticle

Abstract

Objective: Parotid gland carcinoma (PGC) and submandibular gland carcinoma (SMGC) are relatively rare. The aim of this retrospective study was to compare the clinical outcomes of PGC and SMGC. Patients: Our study included 260 patients(195 with PGC and 65 with SMGC) who underwent initial surgical treatment at Kyoto University and its affiliated hospitals between 2006 and 2015. Results: A total of 44% of the PGCs and 58% of the SMGCs were classified as high-grade malignancies. The sensitivity of fine-needle aspiration cytology was 50% for PGC and 75% for SMGC. At a mean follow-up time of 3.6 years, the 3-year overall survival, disease-specific survival (DSS), locoregional control, and no distant metastasis (NDM) rates for PGC were 85 %, 89 %, 85 %, and 87 %, respectively, while those for SMGC were 74 %, 74 %, 90 %, and 65 %, respectively. Furthermore, the DSS and NDM rates for SMGC were statistically significantly lower than those for PGC. Conclusions: In comparison to PGC, SMGC has a higher risk of distant metastasis and a poorer DSS rate.

Original languageEnglish
Pages (from-to)39-45
Number of pages7
JournalJapanese Journal of Head and Neck Cancer
Volume44
Issue number1
DOIs
Publication statusPublished - 01-01-2018
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology
  • Oncology

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    Yamada, K., Honda, K., Tanaka, S., Tamaki, H., Kojima, T., Shinohara, S., Takebayashi, S., Maetani, T., Asato, R., Tateya, I., Kitamura, M., Mizuta, M., Kitani, Y., Ushiro, K., Ichimaru, K., Kumabe, Y., & Omori, K. (2018). The comparison of parotid gland carcinoma and submandibular gland carcinoma―Results of a multi institutional retrospective study. Japanese Journal of Head and Neck Cancer, 44(1), 39-45. https://doi.org/10.5981/jjhnc.44.39