The comparison of the prognosis between Epstein-Barr virus (EBV)-positive gastric carcinomas and EBV-negative ones

Yuko Kijima, Sumiya Ishigami, Shuichi Hokita, Chihaya Koriyama, Suminori Akiba, Yoshito Eizuru, Takashi Aikou

Research output: Contribution to journalArticlepeer-review

48 Citations (Scopus)

Abstract

The relationship between the degree of lymphocytic infiltration into the tumor and the prognosis has not been completely evaluated between Epstein-Barr virus (EBV)-positive and -negative gastric carcinoma (GC). Although the average numbers and the grades of the infiltrating CD8+T cells, natural killer cells, dendritic cells, Ki67-positive cells were significantly greater in EBV-positive GCs than in -negative GCs, there was no significant survival improvement in EBV-positive group. These findings suggest that the infiltration of lymphocytes in the EBV-positive GC does not necessarily meant better prognosis and that the EBV status is not a significant prognostic factor in the patients with gastric cancer.

Original languageEnglish
Pages (from-to)33-40
Number of pages8
JournalCancer Letters
Volume200
Issue number1
DOIs
Publication statusPublished - 08-10-2003
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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