The comparison of the prognosis between Epstein-Barr virus (EBV)-positive gastric carcinomas and EBV-negative ones

Yuko Kijima; Sumiya Ishigami; Shuichi Hokita; Chihaya Koriyama; Suminori Akiba; Yoshito Eizuru; Takashi Aikou

doi:10.1016/S0304-3835(03)00410-5

The comparison of the prognosis between Epstein-Barr virus (EBV)-positive gastric carcinomas and EBV-negative ones

Yuko Kijima, Sumiya Ishigami, Shuichi Hokita, Chihaya Koriyama, Suminori Akiba, Yoshito Eizuru, Takashi Aikou

Research output: Contribution to journal › Article › peer-review

59 Citations (Scopus)

Abstract

The relationship between the degree of lymphocytic infiltration into the tumor and the prognosis has not been completely evaluated between Epstein-Barr virus (EBV)-positive and -negative gastric carcinoma (GC). Although the average numbers and the grades of the infiltrating CD8+T cells, natural killer cells, dendritic cells, Ki67-positive cells were significantly greater in EBV-positive GCs than in -negative GCs, there was no significant survival improvement in EBV-positive group. These findings suggest that the infiltration of lymphocytes in the EBV-positive GC does not necessarily meant better prognosis and that the EBV status is not a significant prognostic factor in the patients with gastric cancer.

Original language	English
Pages (from-to)	33-40
Number of pages	8
Journal	Cancer Letters
Volume	200
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3835(03)00410-5
Publication status	Published - 08-10-2003
Externally published	Yes

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0304-3835(03)00410-5

Cite this

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title = "The comparison of the prognosis between Epstein-Barr virus (EBV)-positive gastric carcinomas and EBV-negative ones",

abstract = "The relationship between the degree of lymphocytic infiltration into the tumor and the prognosis has not been completely evaluated between Epstein-Barr virus (EBV)-positive and -negative gastric carcinoma (GC). Although the average numbers and the grades of the infiltrating CD8+T cells, natural killer cells, dendritic cells, Ki67-positive cells were significantly greater in EBV-positive GCs than in -negative GCs, there was no significant survival improvement in EBV-positive group. These findings suggest that the infiltration of lymphocytes in the EBV-positive GC does not necessarily meant better prognosis and that the EBV status is not a significant prognostic factor in the patients with gastric cancer.",

author = "Yuko Kijima and Sumiya Ishigami and Shuichi Hokita and Chihaya Koriyama and Suminori Akiba and Yoshito Eizuru and Takashi Aikou",

note = "Funding Information: This study was supported in part by Grants-in-Aid for Scientific Research on Priority Areas from the Ministry of Education, Culture, Sports, Science and Technology (Grant No. 12218231).",

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doi = "10.1016/S0304-3835(03)00410-5",

language = "English",

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T1 - The comparison of the prognosis between Epstein-Barr virus (EBV)-positive gastric carcinomas and EBV-negative ones

AU - Kijima, Yuko

AU - Ishigami, Sumiya

AU - Hokita, Shuichi

AU - Koriyama, Chihaya

AU - Akiba, Suminori

AU - Eizuru, Yoshito

AU - Aikou, Takashi

N1 - Funding Information: This study was supported in part by Grants-in-Aid for Scientific Research on Priority Areas from the Ministry of Education, Culture, Sports, Science and Technology (Grant No. 12218231).

PY - 2003/10/8

Y1 - 2003/10/8

N2 - The relationship between the degree of lymphocytic infiltration into the tumor and the prognosis has not been completely evaluated between Epstein-Barr virus (EBV)-positive and -negative gastric carcinoma (GC). Although the average numbers and the grades of the infiltrating CD8+T cells, natural killer cells, dendritic cells, Ki67-positive cells were significantly greater in EBV-positive GCs than in -negative GCs, there was no significant survival improvement in EBV-positive group. These findings suggest that the infiltration of lymphocytes in the EBV-positive GC does not necessarily meant better prognosis and that the EBV status is not a significant prognostic factor in the patients with gastric cancer.

AB - The relationship between the degree of lymphocytic infiltration into the tumor and the prognosis has not been completely evaluated between Epstein-Barr virus (EBV)-positive and -negative gastric carcinoma (GC). Although the average numbers and the grades of the infiltrating CD8+T cells, natural killer cells, dendritic cells, Ki67-positive cells were significantly greater in EBV-positive GCs than in -negative GCs, there was no significant survival improvement in EBV-positive group. These findings suggest that the infiltration of lymphocytes in the EBV-positive GC does not necessarily meant better prognosis and that the EBV status is not a significant prognostic factor in the patients with gastric cancer.

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U2 - 10.1016/S0304-3835(03)00410-5

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SN - 0304-3835

VL - 200

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JO - Cancer Letters

JF - Cancer Letters

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ER -

The comparison of the prognosis between Epstein-Barr virus (EBV)-positive gastric carcinomas and EBV-negative ones

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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