The diagnostic value of the interstitial biomarkers kl-6 and sp-d for the degree of fibrosis in combined pulmonary fibrosis and emphysema

Shigeki Chiba, Hiromitsu Ohta, Kyoko Abe, Shu Hisata, Shinya Ohkouchi, Yasushi Hoshikawa, Takashi Kondo, Masahito Ebina

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The combined pulmonary fibrosis and emphysema (CPFE) was reported first in 1990, but it has been comparatively underestimated until recently. Although the diagnostic findings of both emphysematous and fibrotic regions are detectable by high-resolution computed tomography (HRCT) of the chest, the degree of progressive fibrosis, which increases with emphysematous lesions, is difficult to evaluate. In this study, we hypothesized that the biomarkers for pulmonary fibrosis, surfactant protein D (SP-D), and KL-6 would serve as good indicators of fibrotic lesions in CPFE. We recruited 46 patients who had been diagnosed in our hospital with both emphysema and fibrosis by their CT scan image from April 2003 to March 2008. The correlation among their pulmonary function tests, composite physiologic index (CPI), and the serum levels of SP-D and KL-6 was evaluated. We found a correlation between KL-6 and %VC, %TLC, or CPI and between SP-D and %VC or CPI. Interestingly, the combined product of KL-6 and SP-D (KL-6xSP-D) was found to highly correlate with %VC and %TLC or CPI. These results show that both KL-6 and SP-D, and especially the product of SP-D and KL-6, are good indicators of the presence of fibrotic lesions in the lungs of CPFE patients.

Original languageEnglish
Article number492960
JournalPulmonary Medicine
DOIs
Publication statusPublished - 04-04-2012

Fingerprint

Pulmonary Surfactant-Associated Protein D
Pulmonary Emphysema
Pulmonary Fibrosis
Fibrosis
Biomarkers
Respiratory Function Tests
Emphysema
Thorax
Tomography
Lung
Serum

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine

Cite this

Chiba, Shigeki ; Ohta, Hiromitsu ; Abe, Kyoko ; Hisata, Shu ; Ohkouchi, Shinya ; Hoshikawa, Yasushi ; Kondo, Takashi ; Ebina, Masahito. / The diagnostic value of the interstitial biomarkers kl-6 and sp-d for the degree of fibrosis in combined pulmonary fibrosis and emphysema. In: Pulmonary Medicine. 2012.
@article{7daebe3e062943b887c5f5ebd31e1b0d,
title = "The diagnostic value of the interstitial biomarkers kl-6 and sp-d for the degree of fibrosis in combined pulmonary fibrosis and emphysema",
abstract = "The combined pulmonary fibrosis and emphysema (CPFE) was reported first in 1990, but it has been comparatively underestimated until recently. Although the diagnostic findings of both emphysematous and fibrotic regions are detectable by high-resolution computed tomography (HRCT) of the chest, the degree of progressive fibrosis, which increases with emphysematous lesions, is difficult to evaluate. In this study, we hypothesized that the biomarkers for pulmonary fibrosis, surfactant protein D (SP-D), and KL-6 would serve as good indicators of fibrotic lesions in CPFE. We recruited 46 patients who had been diagnosed in our hospital with both emphysema and fibrosis by their CT scan image from April 2003 to March 2008. The correlation among their pulmonary function tests, composite physiologic index (CPI), and the serum levels of SP-D and KL-6 was evaluated. We found a correlation between KL-6 and {\%}VC, {\%}TLC, or CPI and between SP-D and {\%}VC or CPI. Interestingly, the combined product of KL-6 and SP-D (KL-6xSP-D) was found to highly correlate with {\%}VC and {\%}TLC or CPI. These results show that both KL-6 and SP-D, and especially the product of SP-D and KL-6, are good indicators of the presence of fibrotic lesions in the lungs of CPFE patients.",
author = "Shigeki Chiba and Hiromitsu Ohta and Kyoko Abe and Shu Hisata and Shinya Ohkouchi and Yasushi Hoshikawa and Takashi Kondo and Masahito Ebina",
year = "2012",
month = "4",
day = "4",
doi = "10.1155/2012/492960",
language = "English",
journal = "Pulmonary Medicine",
issn = "2090-1836",
publisher = "Hindawi Publishing Corporation",

}

The diagnostic value of the interstitial biomarkers kl-6 and sp-d for the degree of fibrosis in combined pulmonary fibrosis and emphysema. / Chiba, Shigeki; Ohta, Hiromitsu; Abe, Kyoko; Hisata, Shu; Ohkouchi, Shinya; Hoshikawa, Yasushi; Kondo, Takashi; Ebina, Masahito.

In: Pulmonary Medicine, 04.04.2012.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The diagnostic value of the interstitial biomarkers kl-6 and sp-d for the degree of fibrosis in combined pulmonary fibrosis and emphysema

AU - Chiba, Shigeki

AU - Ohta, Hiromitsu

AU - Abe, Kyoko

AU - Hisata, Shu

AU - Ohkouchi, Shinya

AU - Hoshikawa, Yasushi

AU - Kondo, Takashi

AU - Ebina, Masahito

PY - 2012/4/4

Y1 - 2012/4/4

N2 - The combined pulmonary fibrosis and emphysema (CPFE) was reported first in 1990, but it has been comparatively underestimated until recently. Although the diagnostic findings of both emphysematous and fibrotic regions are detectable by high-resolution computed tomography (HRCT) of the chest, the degree of progressive fibrosis, which increases with emphysematous lesions, is difficult to evaluate. In this study, we hypothesized that the biomarkers for pulmonary fibrosis, surfactant protein D (SP-D), and KL-6 would serve as good indicators of fibrotic lesions in CPFE. We recruited 46 patients who had been diagnosed in our hospital with both emphysema and fibrosis by their CT scan image from April 2003 to March 2008. The correlation among their pulmonary function tests, composite physiologic index (CPI), and the serum levels of SP-D and KL-6 was evaluated. We found a correlation between KL-6 and %VC, %TLC, or CPI and between SP-D and %VC or CPI. Interestingly, the combined product of KL-6 and SP-D (KL-6xSP-D) was found to highly correlate with %VC and %TLC or CPI. These results show that both KL-6 and SP-D, and especially the product of SP-D and KL-6, are good indicators of the presence of fibrotic lesions in the lungs of CPFE patients.

AB - The combined pulmonary fibrosis and emphysema (CPFE) was reported first in 1990, but it has been comparatively underestimated until recently. Although the diagnostic findings of both emphysematous and fibrotic regions are detectable by high-resolution computed tomography (HRCT) of the chest, the degree of progressive fibrosis, which increases with emphysematous lesions, is difficult to evaluate. In this study, we hypothesized that the biomarkers for pulmonary fibrosis, surfactant protein D (SP-D), and KL-6 would serve as good indicators of fibrotic lesions in CPFE. We recruited 46 patients who had been diagnosed in our hospital with both emphysema and fibrosis by their CT scan image from April 2003 to March 2008. The correlation among their pulmonary function tests, composite physiologic index (CPI), and the serum levels of SP-D and KL-6 was evaluated. We found a correlation between KL-6 and %VC, %TLC, or CPI and between SP-D and %VC or CPI. Interestingly, the combined product of KL-6 and SP-D (KL-6xSP-D) was found to highly correlate with %VC and %TLC or CPI. These results show that both KL-6 and SP-D, and especially the product of SP-D and KL-6, are good indicators of the presence of fibrotic lesions in the lungs of CPFE patients.

UR - http://www.scopus.com/inward/record.url?scp=84873167336&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84873167336&partnerID=8YFLogxK

U2 - 10.1155/2012/492960

DO - 10.1155/2012/492960

M3 - Article

JO - Pulmonary Medicine

JF - Pulmonary Medicine

SN - 2090-1836

M1 - 492960

ER -