The distal protection during primary percutaneous coronary intervention alleviates the adverse effects of large thrombus burden on myocardial reperfusion

Hisashi Umeda, Toshiaki Katoh, Mitsunori Iwase, Hideo Izawa, Kohzo Nagata, Kosuke Watanabe, Taro Okada, Takumi Yamada, Tomomitsu Tani, Toyoaki Matsushita, Yoshimasa Murakami, Mitsuhiro Okamoto, Takeshi Shimizu, Toyoaki Murohara, Mitsuhiro Yokota

Research output: Contribution to journalArticle

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Abstract

Background: The presence of intracoronary large thrombus burden (LTB) in the infarct-related artery increases the risk of distal embolization and no-reflow during percutaneous coronary intervention (PCI). Evaluation of whether the distal protection (DP) during primary PCI reduces adverse effects of LTB on myocardial reperfusion and infarct size was investigated. Methods and Results: A consecutive series of 88 patients with acute myocardial infarction undergoing primary PCI using DP were compared with 81 consecutive patients treated by primary PCI alone. The DP use showed similar post-procedural myocardial blush grade (MBG)-3 and infarct size, but improved corrected thrombolysis in myocardial infarction frame count (cTFC) (29±11 vs 35±20, p=0.011) and the incidence of ST-segment resolution (80.7% vs 66.7%, p=0.038). In patients with LTB present, however, the DP use reduced occurrences of no-reflow (0% vs 11.8%, p=0.036) and distal embolization (4.8% vs 17.6%, p=0.129), resulting in higher occurrences of MBG-3 (61.9% vs 35.3%, p=0.021) and ST-segment resolution (78.6% vs 50.0%, p=0.009), lower cTFC values (30±8 vs 40±22, p=0.012) and smaller infarct size (12.2±11.2 vs 18.7±11.1, p=0.015). Conclusions: With an improved myocardial reperfusion and smaller infarct size in patients with LTB, the DP during primary PCI might be a better strategy in this particular setting compared with conventional strategy.

Original languageEnglish
Pages (from-to)232-238
Number of pages7
JournalCirculation Journal
Volume70
Issue number3
DOIs
Publication statusPublished - 07-03-2006
Externally publishedYes

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Myocardial Reperfusion
Percutaneous Coronary Intervention
Thrombosis
Myocardial Infarction
Arteries
Incidence

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Umeda, Hisashi ; Katoh, Toshiaki ; Iwase, Mitsunori ; Izawa, Hideo ; Nagata, Kohzo ; Watanabe, Kosuke ; Okada, Taro ; Yamada, Takumi ; Tani, Tomomitsu ; Matsushita, Toyoaki ; Murakami, Yoshimasa ; Okamoto, Mitsuhiro ; Shimizu, Takeshi ; Murohara, Toyoaki ; Yokota, Mitsuhiro. / The distal protection during primary percutaneous coronary intervention alleviates the adverse effects of large thrombus burden on myocardial reperfusion. In: Circulation Journal. 2006 ; Vol. 70, No. 3. pp. 232-238.
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title = "The distal protection during primary percutaneous coronary intervention alleviates the adverse effects of large thrombus burden on myocardial reperfusion",
abstract = "Background: The presence of intracoronary large thrombus burden (LTB) in the infarct-related artery increases the risk of distal embolization and no-reflow during percutaneous coronary intervention (PCI). Evaluation of whether the distal protection (DP) during primary PCI reduces adverse effects of LTB on myocardial reperfusion and infarct size was investigated. Methods and Results: A consecutive series of 88 patients with acute myocardial infarction undergoing primary PCI using DP were compared with 81 consecutive patients treated by primary PCI alone. The DP use showed similar post-procedural myocardial blush grade (MBG)-3 and infarct size, but improved corrected thrombolysis in myocardial infarction frame count (cTFC) (29±11 vs 35±20, p=0.011) and the incidence of ST-segment resolution (80.7{\%} vs 66.7{\%}, p=0.038). In patients with LTB present, however, the DP use reduced occurrences of no-reflow (0{\%} vs 11.8{\%}, p=0.036) and distal embolization (4.8{\%} vs 17.6{\%}, p=0.129), resulting in higher occurrences of MBG-3 (61.9{\%} vs 35.3{\%}, p=0.021) and ST-segment resolution (78.6{\%} vs 50.0{\%}, p=0.009), lower cTFC values (30±8 vs 40±22, p=0.012) and smaller infarct size (12.2±11.2 vs 18.7±11.1, p=0.015). Conclusions: With an improved myocardial reperfusion and smaller infarct size in patients with LTB, the DP during primary PCI might be a better strategy in this particular setting compared with conventional strategy.",
author = "Hisashi Umeda and Toshiaki Katoh and Mitsunori Iwase and Hideo Izawa and Kohzo Nagata and Kosuke Watanabe and Taro Okada and Takumi Yamada and Tomomitsu Tani and Toyoaki Matsushita and Yoshimasa Murakami and Mitsuhiro Okamoto and Takeshi Shimizu and Toyoaki Murohara and Mitsuhiro Yokota",
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Umeda, H, Katoh, T, Iwase, M, Izawa, H, Nagata, K, Watanabe, K, Okada, T, Yamada, T, Tani, T, Matsushita, T, Murakami, Y, Okamoto, M, Shimizu, T, Murohara, T & Yokota, M 2006, 'The distal protection during primary percutaneous coronary intervention alleviates the adverse effects of large thrombus burden on myocardial reperfusion', Circulation Journal, vol. 70, no. 3, pp. 232-238. https://doi.org/10.1253/circj.70.232

The distal protection during primary percutaneous coronary intervention alleviates the adverse effects of large thrombus burden on myocardial reperfusion. / Umeda, Hisashi; Katoh, Toshiaki; Iwase, Mitsunori; Izawa, Hideo; Nagata, Kohzo; Watanabe, Kosuke; Okada, Taro; Yamada, Takumi; Tani, Tomomitsu; Matsushita, Toyoaki; Murakami, Yoshimasa; Okamoto, Mitsuhiro; Shimizu, Takeshi; Murohara, Toyoaki; Yokota, Mitsuhiro.

In: Circulation Journal, Vol. 70, No. 3, 07.03.2006, p. 232-238.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The distal protection during primary percutaneous coronary intervention alleviates the adverse effects of large thrombus burden on myocardial reperfusion

AU - Umeda, Hisashi

AU - Katoh, Toshiaki

AU - Iwase, Mitsunori

AU - Izawa, Hideo

AU - Nagata, Kohzo

AU - Watanabe, Kosuke

AU - Okada, Taro

AU - Yamada, Takumi

AU - Tani, Tomomitsu

AU - Matsushita, Toyoaki

AU - Murakami, Yoshimasa

AU - Okamoto, Mitsuhiro

AU - Shimizu, Takeshi

AU - Murohara, Toyoaki

AU - Yokota, Mitsuhiro

PY - 2006/3/7

Y1 - 2006/3/7

N2 - Background: The presence of intracoronary large thrombus burden (LTB) in the infarct-related artery increases the risk of distal embolization and no-reflow during percutaneous coronary intervention (PCI). Evaluation of whether the distal protection (DP) during primary PCI reduces adverse effects of LTB on myocardial reperfusion and infarct size was investigated. Methods and Results: A consecutive series of 88 patients with acute myocardial infarction undergoing primary PCI using DP were compared with 81 consecutive patients treated by primary PCI alone. The DP use showed similar post-procedural myocardial blush grade (MBG)-3 and infarct size, but improved corrected thrombolysis in myocardial infarction frame count (cTFC) (29±11 vs 35±20, p=0.011) and the incidence of ST-segment resolution (80.7% vs 66.7%, p=0.038). In patients with LTB present, however, the DP use reduced occurrences of no-reflow (0% vs 11.8%, p=0.036) and distal embolization (4.8% vs 17.6%, p=0.129), resulting in higher occurrences of MBG-3 (61.9% vs 35.3%, p=0.021) and ST-segment resolution (78.6% vs 50.0%, p=0.009), lower cTFC values (30±8 vs 40±22, p=0.012) and smaller infarct size (12.2±11.2 vs 18.7±11.1, p=0.015). Conclusions: With an improved myocardial reperfusion and smaller infarct size in patients with LTB, the DP during primary PCI might be a better strategy in this particular setting compared with conventional strategy.

AB - Background: The presence of intracoronary large thrombus burden (LTB) in the infarct-related artery increases the risk of distal embolization and no-reflow during percutaneous coronary intervention (PCI). Evaluation of whether the distal protection (DP) during primary PCI reduces adverse effects of LTB on myocardial reperfusion and infarct size was investigated. Methods and Results: A consecutive series of 88 patients with acute myocardial infarction undergoing primary PCI using DP were compared with 81 consecutive patients treated by primary PCI alone. The DP use showed similar post-procedural myocardial blush grade (MBG)-3 and infarct size, but improved corrected thrombolysis in myocardial infarction frame count (cTFC) (29±11 vs 35±20, p=0.011) and the incidence of ST-segment resolution (80.7% vs 66.7%, p=0.038). In patients with LTB present, however, the DP use reduced occurrences of no-reflow (0% vs 11.8%, p=0.036) and distal embolization (4.8% vs 17.6%, p=0.129), resulting in higher occurrences of MBG-3 (61.9% vs 35.3%, p=0.021) and ST-segment resolution (78.6% vs 50.0%, p=0.009), lower cTFC values (30±8 vs 40±22, p=0.012) and smaller infarct size (12.2±11.2 vs 18.7±11.1, p=0.015). Conclusions: With an improved myocardial reperfusion and smaller infarct size in patients with LTB, the DP during primary PCI might be a better strategy in this particular setting compared with conventional strategy.

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U2 - 10.1253/circj.70.232

DO - 10.1253/circj.70.232

M3 - Article

VL - 70

SP - 232

EP - 238

JO - Circulation Journal

JF - Circulation Journal

SN - 1346-9843

IS - 3

ER -