The earliest stages of B cell development require a chemokine stromal cell-derived factor/pre-B cell growth-stimulating factor

Takeshi Egawa, Kenji Kawabata, Hiroshi Kawamoto, Kei Amada, Rika Okamoto, Nobutaka Fujii, Tadamitsu Kishimoto, Yoshimoto Katsura, Takashi Nagasawa

Research output: Contribution to journalArticlepeer-review

155 Citations (Scopus)

Abstract

Environmental factors essential for the first stages of B lymphopoiesis remain elusive. Here, we report that immediately after commitment to B lineage, precursors become dependent on a chemokine SDF-1 and its receptor CXCR4 using mutant and radiation chimeric mice. In bone marrow, generation of the earliest identifiable B cell precursor populations requires CXCR4. In fetal liver, we identified Lin-CD19-c-kit+IL-7Rα+AA4. 1+, the earliest unipotent B cell precursor population, and found that its development was severely affected in SDF-1-/- embryos but not in IL-7-/- embryos. Lin- T cell progenitors appeared normal in SDF-1-/- embryos. Moreover, SDF-1 exhibited specific biologic activities on the earliest B cell precursors. SDF-1 provides the first example of a cytokine responsible for the earliest B lineage stages.

Original languageEnglish
Pages (from-to)323-334
Number of pages12
JournalImmunity
Volume15
Issue number2
DOIs
Publication statusPublished - 2001
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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