The effect of β-carotene on lumbar osteophyte formation

Shiro Imagama, Yukiharu Hasegawa, Taisuke Seki, Yukihiro Matsuyama, Yoshihito Sakai, Zenya Ito, Naoki Ishiguro, Yoshinori Ito, Nobuyuki Hamajima, Koji Suzuki

Research output: Contribution to journalArticle

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Abstract

Study Design: Cross-sectional cohort study of elderly people. Objective: The relationships of osteophyte formation on plain lumbar radiographs with serum levels of antioxidants (carotenoids, vitamin A, vitamin E) and other factors were investigated to examine whether antioxidants are involved in lumbar spine degeneration. Summary of Background Data: Antioxidants have inhibitory effects on the onset of many diseases. However, the association of lumbar osteophyte formation with antioxidant levels in the general population has not been investigated. Methods: The subjects were 286 people (103 men and 183 women; mean age = 68 years) who underwent resident health screening. Osteophyte formation on lumbar lateral radiographs (Nathan classification), lumbar lordosis angles, sacral inclination angles, serum levels of antioxidants, triglyceride levels, body mass index, osteoporosis, back muscle strength, history of alcohol intake, and smoking history were studied in these subjects. Results: Lumbar osteophyte formation was detected in 48 subjects (17%). Osteophyte formation was significantly more common in elderly persons, men, and subjects with a history of alcohol intake; and had a significant correlation with sacral inclination angle. The levels of α-tocopherol, β-tocopherol, zeaxanthin/lutein, cryptoxanthin, lycopene, α-carotene, and β-carotene were significantly lower in subjects with osteophytes. Logistic regression analysis adjusted for all factors showed that a higher age (odds ratio [OR] = 1.1, 95% confidence interval [CI] = 1.02-1.16; P = 0.02) and a low β-carotene level (OR = 6.7, 95% CI = 1.39-32.6; P = 0.02) were risk factors for osteophyte formation. Conclusion: The serum levels of carotenoids and vitamin E were significantly lower in subjects with lumbar osteophyte formation, and a low β-carotene level was the strongest risk factor for lumbar osteophytes. This is the first evidence of an association between carotenoids and lumbar osteophyte formation. This finding suggests that appropriate dietary intake of antioxidants is important for inhibition of lumbar spine degeneration in a rapidly aging society.

Original languageEnglish
Pages (from-to)2293-2298
Number of pages6
JournalSpine
Volume36
Issue number26
DOIs
Publication statusPublished - 15-12-2011

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Osteophyte
Carotenoids
Antioxidants
Tocopherols
Spine
Serum
Odds Ratio
Alcohols
Confidence Intervals
Back Muscles
Lutein
Lordosis
Muscle Strength
Vitamin E
Osteoporosis
Triglycerides
Body Mass Index
Cohort Studies
Cross-Sectional Studies
Logistic Models

All Science Journal Classification (ASJC) codes

  • Orthopedics and Sports Medicine
  • Clinical Neurology

Cite this

Imagama, S., Hasegawa, Y., Seki, T., Matsuyama, Y., Sakai, Y., Ito, Z., ... Suzuki, K. (2011). The effect of β-carotene on lumbar osteophyte formation. Spine, 36(26), 2293-2298. https://doi.org/10.1097/BRS.0b013e3182254a18
Imagama, Shiro ; Hasegawa, Yukiharu ; Seki, Taisuke ; Matsuyama, Yukihiro ; Sakai, Yoshihito ; Ito, Zenya ; Ishiguro, Naoki ; Ito, Yoshinori ; Hamajima, Nobuyuki ; Suzuki, Koji. / The effect of β-carotene on lumbar osteophyte formation. In: Spine. 2011 ; Vol. 36, No. 26. pp. 2293-2298.
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abstract = "Study Design: Cross-sectional cohort study of elderly people. Objective: The relationships of osteophyte formation on plain lumbar radiographs with serum levels of antioxidants (carotenoids, vitamin A, vitamin E) and other factors were investigated to examine whether antioxidants are involved in lumbar spine degeneration. Summary of Background Data: Antioxidants have inhibitory effects on the onset of many diseases. However, the association of lumbar osteophyte formation with antioxidant levels in the general population has not been investigated. Methods: The subjects were 286 people (103 men and 183 women; mean age = 68 years) who underwent resident health screening. Osteophyte formation on lumbar lateral radiographs (Nathan classification), lumbar lordosis angles, sacral inclination angles, serum levels of antioxidants, triglyceride levels, body mass index, osteoporosis, back muscle strength, history of alcohol intake, and smoking history were studied in these subjects. Results: Lumbar osteophyte formation was detected in 48 subjects (17{\%}). Osteophyte formation was significantly more common in elderly persons, men, and subjects with a history of alcohol intake; and had a significant correlation with sacral inclination angle. The levels of α-tocopherol, β-tocopherol, zeaxanthin/lutein, cryptoxanthin, lycopene, α-carotene, and β-carotene were significantly lower in subjects with osteophytes. Logistic regression analysis adjusted for all factors showed that a higher age (odds ratio [OR] = 1.1, 95{\%} confidence interval [CI] = 1.02-1.16; P = 0.02) and a low β-carotene level (OR = 6.7, 95{\%} CI = 1.39-32.6; P = 0.02) were risk factors for osteophyte formation. Conclusion: The serum levels of carotenoids and vitamin E were significantly lower in subjects with lumbar osteophyte formation, and a low β-carotene level was the strongest risk factor for lumbar osteophytes. This is the first evidence of an association between carotenoids and lumbar osteophyte formation. This finding suggests that appropriate dietary intake of antioxidants is important for inhibition of lumbar spine degeneration in a rapidly aging society.",
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Imagama, S, Hasegawa, Y, Seki, T, Matsuyama, Y, Sakai, Y, Ito, Z, Ishiguro, N, Ito, Y, Hamajima, N & Suzuki, K 2011, 'The effect of β-carotene on lumbar osteophyte formation', Spine, vol. 36, no. 26, pp. 2293-2298. https://doi.org/10.1097/BRS.0b013e3182254a18

The effect of β-carotene on lumbar osteophyte formation. / Imagama, Shiro; Hasegawa, Yukiharu; Seki, Taisuke; Matsuyama, Yukihiro; Sakai, Yoshihito; Ito, Zenya; Ishiguro, Naoki; Ito, Yoshinori; Hamajima, Nobuyuki; Suzuki, Koji.

In: Spine, Vol. 36, No. 26, 15.12.2011, p. 2293-2298.

Research output: Contribution to journalArticle

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T1 - The effect of β-carotene on lumbar osteophyte formation

AU - Imagama, Shiro

AU - Hasegawa, Yukiharu

AU - Seki, Taisuke

AU - Matsuyama, Yukihiro

AU - Sakai, Yoshihito

AU - Ito, Zenya

AU - Ishiguro, Naoki

AU - Ito, Yoshinori

AU - Hamajima, Nobuyuki

AU - Suzuki, Koji

PY - 2011/12/15

Y1 - 2011/12/15

N2 - Study Design: Cross-sectional cohort study of elderly people. Objective: The relationships of osteophyte formation on plain lumbar radiographs with serum levels of antioxidants (carotenoids, vitamin A, vitamin E) and other factors were investigated to examine whether antioxidants are involved in lumbar spine degeneration. Summary of Background Data: Antioxidants have inhibitory effects on the onset of many diseases. However, the association of lumbar osteophyte formation with antioxidant levels in the general population has not been investigated. Methods: The subjects were 286 people (103 men and 183 women; mean age = 68 years) who underwent resident health screening. Osteophyte formation on lumbar lateral radiographs (Nathan classification), lumbar lordosis angles, sacral inclination angles, serum levels of antioxidants, triglyceride levels, body mass index, osteoporosis, back muscle strength, history of alcohol intake, and smoking history were studied in these subjects. Results: Lumbar osteophyte formation was detected in 48 subjects (17%). Osteophyte formation was significantly more common in elderly persons, men, and subjects with a history of alcohol intake; and had a significant correlation with sacral inclination angle. The levels of α-tocopherol, β-tocopherol, zeaxanthin/lutein, cryptoxanthin, lycopene, α-carotene, and β-carotene were significantly lower in subjects with osteophytes. Logistic regression analysis adjusted for all factors showed that a higher age (odds ratio [OR] = 1.1, 95% confidence interval [CI] = 1.02-1.16; P = 0.02) and a low β-carotene level (OR = 6.7, 95% CI = 1.39-32.6; P = 0.02) were risk factors for osteophyte formation. Conclusion: The serum levels of carotenoids and vitamin E were significantly lower in subjects with lumbar osteophyte formation, and a low β-carotene level was the strongest risk factor for lumbar osteophytes. This is the first evidence of an association between carotenoids and lumbar osteophyte formation. This finding suggests that appropriate dietary intake of antioxidants is important for inhibition of lumbar spine degeneration in a rapidly aging society.

AB - Study Design: Cross-sectional cohort study of elderly people. Objective: The relationships of osteophyte formation on plain lumbar radiographs with serum levels of antioxidants (carotenoids, vitamin A, vitamin E) and other factors were investigated to examine whether antioxidants are involved in lumbar spine degeneration. Summary of Background Data: Antioxidants have inhibitory effects on the onset of many diseases. However, the association of lumbar osteophyte formation with antioxidant levels in the general population has not been investigated. Methods: The subjects were 286 people (103 men and 183 women; mean age = 68 years) who underwent resident health screening. Osteophyte formation on lumbar lateral radiographs (Nathan classification), lumbar lordosis angles, sacral inclination angles, serum levels of antioxidants, triglyceride levels, body mass index, osteoporosis, back muscle strength, history of alcohol intake, and smoking history were studied in these subjects. Results: Lumbar osteophyte formation was detected in 48 subjects (17%). Osteophyte formation was significantly more common in elderly persons, men, and subjects with a history of alcohol intake; and had a significant correlation with sacral inclination angle. The levels of α-tocopherol, β-tocopherol, zeaxanthin/lutein, cryptoxanthin, lycopene, α-carotene, and β-carotene were significantly lower in subjects with osteophytes. Logistic regression analysis adjusted for all factors showed that a higher age (odds ratio [OR] = 1.1, 95% confidence interval [CI] = 1.02-1.16; P = 0.02) and a low β-carotene level (OR = 6.7, 95% CI = 1.39-32.6; P = 0.02) were risk factors for osteophyte formation. Conclusion: The serum levels of carotenoids and vitamin E were significantly lower in subjects with lumbar osteophyte formation, and a low β-carotene level was the strongest risk factor for lumbar osteophytes. This is the first evidence of an association between carotenoids and lumbar osteophyte formation. This finding suggests that appropriate dietary intake of antioxidants is important for inhibition of lumbar spine degeneration in a rapidly aging society.

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Imagama S, Hasegawa Y, Seki T, Matsuyama Y, Sakai Y, Ito Z et al. The effect of β-carotene on lumbar osteophyte formation. Spine. 2011 Dec 15;36(26):2293-2298. https://doi.org/10.1097/BRS.0b013e3182254a18