The effect of consuming small volumes of beer on gastric motility and the involvement of gene polymorphisms

Tomoyuki Shibata, Hiromi Yamashita, Tomohiko Kawamura, Yasutaka Jodai, Takafumi Omori, Kazuya Sumi, Yuichiro Ichikawa, Masaaki Okubo, Takamitsu Ishizuka, Tomomitsu Tahara, Mitsuo Nagasaka, Yoshihito Nakagawa, Ichiro Hirata, Naoki Ohmiya, Makoto Nakao

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The aim of this study was to investigate the effect of consuming small amounts of beer or a nonalcoholic beer taste beverage (non-beer) on gastric emptying and the polymorphisms in alcohol metabolism-related enzyme-encoding genes. Twenty male healthy volunteers were questioned regarding their alcohol consumption status,and body measurement was performed. The genetic polymorphisms in ADH1B (rs1229984,Arg47His) and ALDH2 (rs671 Glu487Lys) were analyzed. The subjects consumed 150 mL of beer or non-beer once per week,followed by the ingestion of 200 kcal of the test nutrient containing 13C-acetate 15 min later,after which the subjects’ exhalations were collected up to 120 min. The concentration peak of 13C was measured as Tmax. Diamine oxidase (DAO) activity for the marker of small intestinal function activity was also measured the day after the test. Gastric emptying was significantly slower in the group that consumed a small amount of beer,and in daily beer consumption group,and also in the ADH1B */*2,ALDH2 *1/*2 genotypes compared to non-beer drinking group. DAO values were not significantly changed between beer and non-beer group. The consumption of even a small amount of beer and the polymorphisms in ADH1B / ALDH2 affects gastric motility.

Original languageEnglish
Pages (from-to)305-310
Number of pages6
JournalBiomedical Research (Japan)
Volume37
Issue number5
DOIs
Publication statusPublished - 01-01-2016

Fingerprint

Beer
Polymorphism
Stomach
Genes
Amine Oxidase (Copper-Containing)
Gastric Emptying
Alcohols
Exhalation
Gene encoding
Beverages
Genetic Polymorphisms
Metabolism
Alcohol Drinking
Nutrients
Drinking
Healthy Volunteers
Acetates
Eating
Genotype
Food

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Shibata, T., Yamashita, H., Kawamura, T., Jodai, Y., Omori, T., Sumi, K., ... Nakao, M. (2016). The effect of consuming small volumes of beer on gastric motility and the involvement of gene polymorphisms. Biomedical Research (Japan), 37(5), 305-310. https://doi.org/10.2220/biomedres.37.305
Shibata, Tomoyuki ; Yamashita, Hiromi ; Kawamura, Tomohiko ; Jodai, Yasutaka ; Omori, Takafumi ; Sumi, Kazuya ; Ichikawa, Yuichiro ; Okubo, Masaaki ; Ishizuka, Takamitsu ; Tahara, Tomomitsu ; Nagasaka, Mitsuo ; Nakagawa, Yoshihito ; Hirata, Ichiro ; Ohmiya, Naoki ; Nakao, Makoto. / The effect of consuming small volumes of beer on gastric motility and the involvement of gene polymorphisms. In: Biomedical Research (Japan). 2016 ; Vol. 37, No. 5. pp. 305-310.
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Shibata, T, Yamashita, H, Kawamura, T, Jodai, Y, Omori, T, Sumi, K, Ichikawa, Y, Okubo, M, Ishizuka, T, Tahara, T, Nagasaka, M, Nakagawa, Y, Hirata, I, Ohmiya, N & Nakao, M 2016, 'The effect of consuming small volumes of beer on gastric motility and the involvement of gene polymorphisms', Biomedical Research (Japan), vol. 37, no. 5, pp. 305-310. https://doi.org/10.2220/biomedres.37.305

The effect of consuming small volumes of beer on gastric motility and the involvement of gene polymorphisms. / Shibata, Tomoyuki; Yamashita, Hiromi; Kawamura, Tomohiko; Jodai, Yasutaka; Omori, Takafumi; Sumi, Kazuya; Ichikawa, Yuichiro; Okubo, Masaaki; Ishizuka, Takamitsu; Tahara, Tomomitsu; Nagasaka, Mitsuo; Nakagawa, Yoshihito; Hirata, Ichiro; Ohmiya, Naoki; Nakao, Makoto.

In: Biomedical Research (Japan), Vol. 37, No. 5, 01.01.2016, p. 305-310.

Research output: Contribution to journalArticle

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T1 - The effect of consuming small volumes of beer on gastric motility and the involvement of gene polymorphisms

AU - Shibata, Tomoyuki

AU - Yamashita, Hiromi

AU - Kawamura, Tomohiko

AU - Jodai, Yasutaka

AU - Omori, Takafumi

AU - Sumi, Kazuya

AU - Ichikawa, Yuichiro

AU - Okubo, Masaaki

AU - Ishizuka, Takamitsu

AU - Tahara, Tomomitsu

AU - Nagasaka, Mitsuo

AU - Nakagawa, Yoshihito

AU - Hirata, Ichiro

AU - Ohmiya, Naoki

AU - Nakao, Makoto

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