TY - JOUR
T1 - The effect of education regarding treatment guidelines for schizophrenia and major depressive disorders on psychiatrists' hypnotic medication prescribing behavior
T2 - a multicenter study
AU - Nakamura, Toshinori
AU - Furihata, Ryuji
AU - Hasegawa, Naomi
AU - Kodaka, Fumitoshi
AU - Muraoka, Hiroyuki
AU - Ichihashi, Kayo
AU - Ochi, Shinichiro
AU - Numata, Shusuke
AU - Tsuboi, Takashi
AU - Makinodan, Manabu
AU - Iida, Hitoshi
AU - Onitsuka, Toshiaki
AU - Kashiwagi, Hiroko
AU - Takeshima, Masahiro
AU - Hashimoto, Naoki
AU - Nagasawa, Tatsuya
AU - Usami, Masahide
AU - Yamagata, Hirotaka
AU - Takaesu, Yoshikazu
AU - Miura, Kenichiro
AU - Matsumoto, Junya
AU - Ohi, Kazutaka
AU - Yamada, Hisashi
AU - Hori, Hikaru
AU - Inada, Ken
AU - Watanabe, Koichiro
AU - Hashimoto, Ryota
AU - Yasui-Furukori, Norio
N1 - Publisher Copyright:
© The Author(s) 2024.
PY - 2024/12
Y1 - 2024/12
N2 - Background: To examine whether the "Effectiveness of Guideline for Dissemination and Education in psychiatric treatment (EGIUDE)" project affects the rate of prescriptions of hypnotic medication and the type of hypnotic medications prescribed among psychiatrists, for schizophrenia and major depressive disorder in Japan. Methods: The EGUIDE project is a nationwide prospective study of evidence-based clinical guidelines for schizophrenia and major depressive disorder in Japan. From 2016 to 2021, clinical and prescribing data from patients discharged from hospitals participating in the EGUIDE project were used to examine hypnotic medication prescriptions The prescribing rate of hypnotics and the prescribing rate of each type of hypnotic (benzodiazepine receptor agonist, nonbenzodiazepine receptor agonist, melatonin receptor agonist, and orexin receptor antagonist) were compared among patients who had been prescribed medication by psychiatrists participating in the EGUIDE project and patients who had been prescribed medication by nonparticipating psychiatrists. Multivariate logistic regression analysis was performed to examine the effect of the EGUIDE project on the prescription of hypnotic medications. Results: A total of 12,161 patients with schizophrenia and 6,167 patients with major depressive disorder were included. Psychiatrists participating in the EGUIDE project significantly reduced the rate of prescribing hypnotic medication and benzodiazepine receptor agonists for both schizophrenia (P < 0.001) and major depressive disorder (P < 0.001) patients. Conclusion: This is the first study to investigate the educational effects of guidelines for the treatment of psychiatric disorders on psychiatrists in terms of prescribing hypnotic medications to patients. The EGUIDE project may play an important role in reducing hypnotic medication prescription rates, particularly with respect to benzodiazepine receptor agonists. The results suggest that the EGUIDE project may result in improved therapeutic behavior.
AB - Background: To examine whether the "Effectiveness of Guideline for Dissemination and Education in psychiatric treatment (EGIUDE)" project affects the rate of prescriptions of hypnotic medication and the type of hypnotic medications prescribed among psychiatrists, for schizophrenia and major depressive disorder in Japan. Methods: The EGUIDE project is a nationwide prospective study of evidence-based clinical guidelines for schizophrenia and major depressive disorder in Japan. From 2016 to 2021, clinical and prescribing data from patients discharged from hospitals participating in the EGUIDE project were used to examine hypnotic medication prescriptions The prescribing rate of hypnotics and the prescribing rate of each type of hypnotic (benzodiazepine receptor agonist, nonbenzodiazepine receptor agonist, melatonin receptor agonist, and orexin receptor antagonist) were compared among patients who had been prescribed medication by psychiatrists participating in the EGUIDE project and patients who had been prescribed medication by nonparticipating psychiatrists. Multivariate logistic regression analysis was performed to examine the effect of the EGUIDE project on the prescription of hypnotic medications. Results: A total of 12,161 patients with schizophrenia and 6,167 patients with major depressive disorder were included. Psychiatrists participating in the EGUIDE project significantly reduced the rate of prescribing hypnotic medication and benzodiazepine receptor agonists for both schizophrenia (P < 0.001) and major depressive disorder (P < 0.001) patients. Conclusion: This is the first study to investigate the educational effects of guidelines for the treatment of psychiatric disorders on psychiatrists in terms of prescribing hypnotic medications to patients. The EGUIDE project may play an important role in reducing hypnotic medication prescription rates, particularly with respect to benzodiazepine receptor agonists. The results suggest that the EGUIDE project may result in improved therapeutic behavior.
KW - Clinical practice guideline
KW - Hypnotic medication
KW - Major depressive disorders
KW - Psychiatrist
KW - Schizophrenia
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UR - http://www.scopus.com/inward/citedby.url?scp=85194838825&partnerID=8YFLogxK
U2 - 10.1186/s12888-024-05816-x
DO - 10.1186/s12888-024-05816-x
M3 - Article
C2 - 38807065
AN - SCOPUS:85194838825
SN - 1471-244X
VL - 24
JO - BMC Psychiatry
JF - BMC Psychiatry
IS - 1
M1 - 399
ER -
