The effect of interim FDG-PET-guided response-adapted therapy in pediatric patients with hodgkin's lymphoma (HL-14): Protocol for a phase II study

Yuhki Koga; Shingo Baba; Reiji Fukano; Katsumasa Nakamura; Toshinori Soejima; Naoko Maeda; Shosuke Sunami; Junichi Ueyama; Tetsuo Mitsui; Takeshi Mori; Tomoo Osumi; Masahiro Sekimizu; Kentaro Ohki; Fumiko Tanaka; Michi Kamei; Naoto Fujita; Tetsuya Mori; Akiko M. Saito; Akiko Kada; Ryoji Kobayashi

The effect of interim FDG-PET-guided response-adapted therapy in pediatric patients with hodgkin's lymphoma (HL-14): Protocol for a phase II study

Yuhki Koga, Shingo Baba, Reiji Fukano, Katsumasa Nakamura, Toshinori Soejima, Naoko Maeda, Shosuke Sunami, Junichi Ueyama, Tetsuo Mitsui, Takeshi Mori, Tomoo Osumi, Masahiro Sekimizu, Kentaro Ohki, Fumiko Tanaka, Michi Kamei, Naoto Fujita, Tetsuya Mori, Akiko M. Saito, Akiko Kada, Ryoji Kobayashi

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

This trial enrolls patients with untreated Hodgkin's lymphoma aged<20 years at diagnosis and examines the effects of omitting radiation therapy if the FDG-positron emission tomography (PET) findings after two completed cycles of combination chemotherapy are negative. It thereby aims to determine whether patients who truly require radiation therapy can be identified by FDG-PET. If so, this modality could be used to omit radiation therapy for all other patients, decreasing the risk of serious long-term complications without affecting survival rates. The outcomes of patients for whom FDG-PET is used to assess early treatment response will also be determined.

Original language	English
Pages (from-to)	437-440
Number of pages	4
Journal	Acta Medica Okayama
Volume	72
Issue number	4
Publication status	Published - 2018
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Biochemistry,Genetics and Molecular Biology

Cite this

Koga, Y., Baba, S., Fukano, R., Nakamura, K., Soejima, T., Maeda, N., Sunami, S., Ueyama, J., Mitsui, T., Mori, T., Osumi, T., Sekimizu, M., Ohki, K., Tanaka, F., Kamei, M., Fujita, N., Mori, T., Saito, A. M., Kada, A., & Kobayashi, R. (2018). The effect of interim FDG-PET-guided response-adapted therapy in pediatric patients with hodgkin's lymphoma (HL-14): Protocol for a phase II study. Acta Medica Okayama, 72(4), 437-440.

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title = "The effect of interim FDG-PET-guided response-adapted therapy in pediatric patients with hodgkin's lymphoma (HL-14): Protocol for a phase II study",

abstract = "This trial enrolls patients with untreated Hodgkin's lymphoma aged<20 years at diagnosis and examines the effects of omitting radiation therapy if the FDG-positron emission tomography (PET) findings after two completed cycles of combination chemotherapy are negative. It thereby aims to determine whether patients who truly require radiation therapy can be identified by FDG-PET. If so, this modality could be used to omit radiation therapy for all other patients, decreasing the risk of serious long-term complications without affecting survival rates. The outcomes of patients for whom FDG-PET is used to assess early treatment response will also be determined.",

author = "Yuhki Koga and Shingo Baba and Reiji Fukano and Katsumasa Nakamura and Toshinori Soejima and Naoko Maeda and Shosuke Sunami and Junichi Ueyama and Tetsuo Mitsui and Takeshi Mori and Tomoo Osumi and Masahiro Sekimizu and Kentaro Ohki and Fumiko Tanaka and Michi Kamei and Naoto Fujita and Tetsuya Mori and Saito, {Akiko M.} and Akiko Kada and Ryoji Kobayashi",

note = "Publisher Copyright: {\textcopyright}2018 by Okayama University Medical School.",

year = "2018",

language = "English",

volume = "72",

pages = "437--440",

journal = "Acta Medica Okayama",

issn = "0386-300X",

publisher = "Okayama University",

number = "4",

}

Koga, Y, Baba, S, Fukano, R, Nakamura, K, Soejima, T, Maeda, N, Sunami, S, Ueyama, J, Mitsui, T, Mori, T, Osumi, T, Sekimizu, M, Ohki, K, Tanaka, F, Kamei, M, Fujita, N, Mori, T, Saito, AM, Kada, A & Kobayashi, R 2018, 'The effect of interim FDG-PET-guided response-adapted therapy in pediatric patients with hodgkin's lymphoma (HL-14): Protocol for a phase II study', Acta Medica Okayama, vol. 72, no. 4, pp. 437-440.

TY - JOUR

T1 - The effect of interim FDG-PET-guided response-adapted therapy in pediatric patients with hodgkin's lymphoma (HL-14)

T2 - Protocol for a phase II study

AU - Koga, Yuhki

AU - Baba, Shingo

AU - Fukano, Reiji

AU - Nakamura, Katsumasa

AU - Soejima, Toshinori

AU - Maeda, Naoko

AU - Sunami, Shosuke

AU - Ueyama, Junichi

AU - Mitsui, Tetsuo

AU - Mori, Takeshi

AU - Osumi, Tomoo

AU - Sekimizu, Masahiro

AU - Ohki, Kentaro

AU - Tanaka, Fumiko

AU - Kamei, Michi

AU - Fujita, Naoto

AU - Mori, Tetsuya

AU - Saito, Akiko M.

AU - Kada, Akiko

AU - Kobayashi, Ryoji

PY - 2018

Y1 - 2018

N2 - This trial enrolls patients with untreated Hodgkin's lymphoma aged<20 years at diagnosis and examines the effects of omitting radiation therapy if the FDG-positron emission tomography (PET) findings after two completed cycles of combination chemotherapy are negative. It thereby aims to determine whether patients who truly require radiation therapy can be identified by FDG-PET. If so, this modality could be used to omit radiation therapy for all other patients, decreasing the risk of serious long-term complications without affecting survival rates. The outcomes of patients for whom FDG-PET is used to assess early treatment response will also be determined.

AB - This trial enrolls patients with untreated Hodgkin's lymphoma aged<20 years at diagnosis and examines the effects of omitting radiation therapy if the FDG-positron emission tomography (PET) findings after two completed cycles of combination chemotherapy are negative. It thereby aims to determine whether patients who truly require radiation therapy can be identified by FDG-PET. If so, this modality could be used to omit radiation therapy for all other patients, decreasing the risk of serious long-term complications without affecting survival rates. The outcomes of patients for whom FDG-PET is used to assess early treatment response will also be determined.

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AN - SCOPUS:85051869337

SN - 0386-300X

VL - 72

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JO - Acta Medica Okayama

JF - Acta Medica Okayama

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ER -

The effect of interim FDG-PET-guided response-adapted therapy in pediatric patients with hodgkin's lymphoma (HL-14): Protocol for a phase II study

Abstract

All Science Journal Classification (ASJC) codes

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