The Effect of Ketotifen on the Generation of Reactive Oxygen Species

Hirohiko Akamatsu; Maki Asaba; Setsuko Nishijima; Yasuo Asada; Yukie Niwa

doi:10.2336/nishinihonhifu.54.293

The Effect of Ketotifen on the Generation of Reactive Oxygen Species

Hirohiko Akamatsu, Maki Asaba, Setsuko Nishijima, Yasuo Asada, Yukie Niwa

Research output: Contribution to journal › Article › peer-review

Abstract

The effect of ketotifan on the reactive oxygen species (ROS) levels generated by neutrophils was examined. ROS generated in a cell-free, xanthine-xanthine oxidase system was also assessed The species investigated were superoxide radical anion (O^-M₂), hydrogen peroxide (H₂O₂) and hydroxyl radical (OH.) Ketotifen significantly decreased the levels of O^-₂. H₂O₂ and OH• generated by neutrophils. However. the agent did not markedly affect the ROS levels generated in the xanthine-xanthine oxidase system. The present study indicates that ketotifen is not an ROS scavenger but exerts an anti inflammatory action by inhibiting neutrophil derived ROS generation at the sites of inflammation.

Original language	English
Pages (from-to)	293-296
Number of pages	4
Journal	Nishi Nihon Hifuka
Volume	54
Issue number	2
DOIs	https://doi.org/10.2336/nishinihonhifu.54.293
Publication status	Published - 01-01-1992
Externally published	Yes

All Science Journal Classification (ASJC) codes

Dermatology

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title = "The Effect of Ketotifen on the Generation of Reactive Oxygen Species",

abstract = "The effect of ketotifan on the reactive oxygen species (ROS) levels generated by neutrophils was examined. ROS generated in a cell-free, xanthine-xanthine oxidase system was also assessed The species investigated were superoxide radical anion (O-M2), hydrogen peroxide (H2O2) and hydroxyl radical (OH.) Ketotifen significantly decreased the levels of O-2. H2O2 and OH• generated by neutrophils. However. the agent did not markedly affect the ROS levels generated in the xanthine-xanthine oxidase system. The present study indicates that ketotifen is not an ROS scavenger but exerts an anti inflammatory action by inhibiting neutrophil derived ROS generation at the sites of inflammation.",

author = "Hirohiko Akamatsu and Maki Asaba and Setsuko Nishijima and Yasuo Asada and Yukie Niwa",

year = "1992",

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doi = "10.2336/nishinihonhifu.54.293",

language = "English",

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T1 - The Effect of Ketotifen on the Generation of Reactive Oxygen Species

AU - Akamatsu, Hirohiko

AU - Asaba, Maki

AU - Nishijima, Setsuko

AU - Asada, Yasuo

AU - Niwa, Yukie

PY - 1992/1/1

Y1 - 1992/1/1

N2 - The effect of ketotifan on the reactive oxygen species (ROS) levels generated by neutrophils was examined. ROS generated in a cell-free, xanthine-xanthine oxidase system was also assessed The species investigated were superoxide radical anion (O-M2), hydrogen peroxide (H2O2) and hydroxyl radical (OH.) Ketotifen significantly decreased the levels of O-2. H2O2 and OH• generated by neutrophils. However. the agent did not markedly affect the ROS levels generated in the xanthine-xanthine oxidase system. The present study indicates that ketotifen is not an ROS scavenger but exerts an anti inflammatory action by inhibiting neutrophil derived ROS generation at the sites of inflammation.

AB - The effect of ketotifan on the reactive oxygen species (ROS) levels generated by neutrophils was examined. ROS generated in a cell-free, xanthine-xanthine oxidase system was also assessed The species investigated were superoxide radical anion (O-M2), hydrogen peroxide (H2O2) and hydroxyl radical (OH.) Ketotifen significantly decreased the levels of O-2. H2O2 and OH• generated by neutrophils. However. the agent did not markedly affect the ROS levels generated in the xanthine-xanthine oxidase system. The present study indicates that ketotifen is not an ROS scavenger but exerts an anti inflammatory action by inhibiting neutrophil derived ROS generation at the sites of inflammation.

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The Effect of Ketotifen on the Generation of Reactive Oxygen Species

Abstract

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