The effect of metabolic syndrome defined by various criteria on the development of ischemic stroke subtypes in a general Japanese population

Jun Hata, Yasufumi Doi, Toshiharu Ninomiya, Yumihiro Tanizaki, Koji Yonemoto, Masayo Fukuhara, Michiaki Kubo, Takanari Kitazono, Mitsuo Iida, Yutaka Kiyohara

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Objective: We evaluated the impact of metabolic syndrome (MetS) defined by various criteria on the occurrence of ischemic stroke subtypes in a general Japanese population. Methods: A total of 2452 residents of a Japanese community, Hisayama, aged 40 years or older, were followed up for 14 years. To define MetS, we used the original Japanese criteria, the modified Japanese criteria, the International Diabetes Federation (IDF) criteria, the original National Cholesterol Education Program's Adult Treatment Panel III (NCEP) criteria, and the modified NCEP criteria. We substituted a waist circumference of ≥90. cm in men and ≥80. cm in women for the values of ≥85. cm and ≥90. cm, respectively, in the modified Japanese criteria and for >102. cm and >88. cm, respectively, in the modified NCEP criteria. Results: Only MetS defined by the modified Japanese criteria showed a significant association with the development of lacunar infarction, and its hazard ratios (HRs) for the development of atherothrombotic and cardioembolic infarction were significant and greater than those of MetS defined by the other criteria: adjusted HRs for lacunar, atherothrombotic and cardioembolic infarction were 1.94 (95% confidence interval (CI), 1.13-3.32; P=0.02), 2.55 (95% CI, 1.25-5.18; P=0.01) and 3.94 (95% CI, 1.89-8.22, P<0.001), respectively, after adjustment for confounding factors. Conclusion: Our findings suggest that MetS defined by the Japanese criteria with the modification of a waist circumference of ≥90. cm in men and ≥80. cm in women is a better predictor of each ischemic stroke subtype in the Japanese population.

Original languageEnglish
Pages (from-to)249-255
Number of pages7
JournalAtherosclerosis
Volume210
Issue number1
DOIs
Publication statusPublished - 01-05-2010

Fingerprint

Stroke
Population
Waist Circumference
Confidence Intervals
Infarction
Lacunar Stroke
Cholesterol
Education
Therapeutics

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Hata, Jun ; Doi, Yasufumi ; Ninomiya, Toshiharu ; Tanizaki, Yumihiro ; Yonemoto, Koji ; Fukuhara, Masayo ; Kubo, Michiaki ; Kitazono, Takanari ; Iida, Mitsuo ; Kiyohara, Yutaka. / The effect of metabolic syndrome defined by various criteria on the development of ischemic stroke subtypes in a general Japanese population. In: Atherosclerosis. 2010 ; Vol. 210, No. 1. pp. 249-255.
@article{706efabac971456a8340d65b2d7a70c4,
title = "The effect of metabolic syndrome defined by various criteria on the development of ischemic stroke subtypes in a general Japanese population",
abstract = "Objective: We evaluated the impact of metabolic syndrome (MetS) defined by various criteria on the occurrence of ischemic stroke subtypes in a general Japanese population. Methods: A total of 2452 residents of a Japanese community, Hisayama, aged 40 years or older, were followed up for 14 years. To define MetS, we used the original Japanese criteria, the modified Japanese criteria, the International Diabetes Federation (IDF) criteria, the original National Cholesterol Education Program's Adult Treatment Panel III (NCEP) criteria, and the modified NCEP criteria. We substituted a waist circumference of ≥90. cm in men and ≥80. cm in women for the values of ≥85. cm and ≥90. cm, respectively, in the modified Japanese criteria and for >102. cm and >88. cm, respectively, in the modified NCEP criteria. Results: Only MetS defined by the modified Japanese criteria showed a significant association with the development of lacunar infarction, and its hazard ratios (HRs) for the development of atherothrombotic and cardioembolic infarction were significant and greater than those of MetS defined by the other criteria: adjusted HRs for lacunar, atherothrombotic and cardioembolic infarction were 1.94 (95{\%} confidence interval (CI), 1.13-3.32; P=0.02), 2.55 (95{\%} CI, 1.25-5.18; P=0.01) and 3.94 (95{\%} CI, 1.89-8.22, P<0.001), respectively, after adjustment for confounding factors. Conclusion: Our findings suggest that MetS defined by the Japanese criteria with the modification of a waist circumference of ≥90. cm in men and ≥80. cm in women is a better predictor of each ischemic stroke subtype in the Japanese population.",
author = "Jun Hata and Yasufumi Doi and Toshiharu Ninomiya and Yumihiro Tanizaki and Koji Yonemoto and Masayo Fukuhara and Michiaki Kubo and Takanari Kitazono and Mitsuo Iida and Yutaka Kiyohara",
year = "2010",
month = "5",
day = "1",
doi = "10.1016/j.atherosclerosis.2009.10.044",
language = "English",
volume = "210",
pages = "249--255",
journal = "Atherosclerosis",
issn = "0021-9150",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

Hata, J, Doi, Y, Ninomiya, T, Tanizaki, Y, Yonemoto, K, Fukuhara, M, Kubo, M, Kitazono, T, Iida, M & Kiyohara, Y 2010, 'The effect of metabolic syndrome defined by various criteria on the development of ischemic stroke subtypes in a general Japanese population', Atherosclerosis, vol. 210, no. 1, pp. 249-255. https://doi.org/10.1016/j.atherosclerosis.2009.10.044

The effect of metabolic syndrome defined by various criteria on the development of ischemic stroke subtypes in a general Japanese population. / Hata, Jun; Doi, Yasufumi; Ninomiya, Toshiharu; Tanizaki, Yumihiro; Yonemoto, Koji; Fukuhara, Masayo; Kubo, Michiaki; Kitazono, Takanari; Iida, Mitsuo; Kiyohara, Yutaka.

In: Atherosclerosis, Vol. 210, No. 1, 01.05.2010, p. 249-255.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The effect of metabolic syndrome defined by various criteria on the development of ischemic stroke subtypes in a general Japanese population

AU - Hata, Jun

AU - Doi, Yasufumi

AU - Ninomiya, Toshiharu

AU - Tanizaki, Yumihiro

AU - Yonemoto, Koji

AU - Fukuhara, Masayo

AU - Kubo, Michiaki

AU - Kitazono, Takanari

AU - Iida, Mitsuo

AU - Kiyohara, Yutaka

PY - 2010/5/1

Y1 - 2010/5/1

N2 - Objective: We evaluated the impact of metabolic syndrome (MetS) defined by various criteria on the occurrence of ischemic stroke subtypes in a general Japanese population. Methods: A total of 2452 residents of a Japanese community, Hisayama, aged 40 years or older, were followed up for 14 years. To define MetS, we used the original Japanese criteria, the modified Japanese criteria, the International Diabetes Federation (IDF) criteria, the original National Cholesterol Education Program's Adult Treatment Panel III (NCEP) criteria, and the modified NCEP criteria. We substituted a waist circumference of ≥90. cm in men and ≥80. cm in women for the values of ≥85. cm and ≥90. cm, respectively, in the modified Japanese criteria and for >102. cm and >88. cm, respectively, in the modified NCEP criteria. Results: Only MetS defined by the modified Japanese criteria showed a significant association with the development of lacunar infarction, and its hazard ratios (HRs) for the development of atherothrombotic and cardioembolic infarction were significant and greater than those of MetS defined by the other criteria: adjusted HRs for lacunar, atherothrombotic and cardioembolic infarction were 1.94 (95% confidence interval (CI), 1.13-3.32; P=0.02), 2.55 (95% CI, 1.25-5.18; P=0.01) and 3.94 (95% CI, 1.89-8.22, P<0.001), respectively, after adjustment for confounding factors. Conclusion: Our findings suggest that MetS defined by the Japanese criteria with the modification of a waist circumference of ≥90. cm in men and ≥80. cm in women is a better predictor of each ischemic stroke subtype in the Japanese population.

AB - Objective: We evaluated the impact of metabolic syndrome (MetS) defined by various criteria on the occurrence of ischemic stroke subtypes in a general Japanese population. Methods: A total of 2452 residents of a Japanese community, Hisayama, aged 40 years or older, were followed up for 14 years. To define MetS, we used the original Japanese criteria, the modified Japanese criteria, the International Diabetes Federation (IDF) criteria, the original National Cholesterol Education Program's Adult Treatment Panel III (NCEP) criteria, and the modified NCEP criteria. We substituted a waist circumference of ≥90. cm in men and ≥80. cm in women for the values of ≥85. cm and ≥90. cm, respectively, in the modified Japanese criteria and for >102. cm and >88. cm, respectively, in the modified NCEP criteria. Results: Only MetS defined by the modified Japanese criteria showed a significant association with the development of lacunar infarction, and its hazard ratios (HRs) for the development of atherothrombotic and cardioembolic infarction were significant and greater than those of MetS defined by the other criteria: adjusted HRs for lacunar, atherothrombotic and cardioembolic infarction were 1.94 (95% confidence interval (CI), 1.13-3.32; P=0.02), 2.55 (95% CI, 1.25-5.18; P=0.01) and 3.94 (95% CI, 1.89-8.22, P<0.001), respectively, after adjustment for confounding factors. Conclusion: Our findings suggest that MetS defined by the Japanese criteria with the modification of a waist circumference of ≥90. cm in men and ≥80. cm in women is a better predictor of each ischemic stroke subtype in the Japanese population.

UR - http://www.scopus.com/inward/record.url?scp=77952430897&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77952430897&partnerID=8YFLogxK

U2 - 10.1016/j.atherosclerosis.2009.10.044

DO - 10.1016/j.atherosclerosis.2009.10.044

M3 - Article

C2 - 19942219

AN - SCOPUS:77952430897

VL - 210

SP - 249

EP - 255

JO - Atherosclerosis

JF - Atherosclerosis

SN - 0021-9150

IS - 1

ER -