The effect of optical isomers of 3,4-methylenedioxymethamphetamine (MDMA) on stereotyped behavior in rats

M. Hiramatsu, T. Nabeshima, T. Kameyama, Y. Maeda, A. K. Cho

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

The relative potencies of S(+)-, R(-)-3,4-methylenedioxymethamphetamine (MDMA) and S(+)-methylenedioxyamphetamine (MDA) in inducing stereotyped behavior were determined in comparison with p-chloroamphetamine. S(+)-MDMA was more potent than R(-)-MDMA in eliciting stereotyped behaviors such as sniffing, head-weaving, backpedalling and turning and wet-dog-shakes. These results are consistent with the actions of the drug on release of neurotransmitters in which the S(+) enantiomer is more potent. The desmethyl derivative of (+)MDMA, (+)MDA, was more potent than (+)MDMA in eliciting stereotyped behaviors, and produced wet-dog shake behavior.

Original languageEnglish
Pages (from-to)343-347
Number of pages5
JournalPharmacology, Biochemistry and Behavior
Volume33
Issue number2
DOIs
Publication statusPublished - 06-1989
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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