Abstract
The relative potencies of S(+)-, R(-)-3,4-methylenedioxymethamphetamine (MDMA) and S(+)-methylenedioxyamphetamine (MDA) in inducing stereotyped behavior were determined in comparison with p-chloroamphetamine. S(+)-MDMA was more potent than R(-)-MDMA in eliciting stereotyped behaviors such as sniffing, head-weaving, backpedalling and turning and wet-dog-shakes. These results are consistent with the actions of the drug on release of neurotransmitters in which the S(+) enantiomer is more potent. The desmethyl derivative of (+)MDMA, (+)MDA, was more potent than (+)MDMA in eliciting stereotyped behaviors, and produced wet-dog shake behavior.
| Original language | English |
|---|---|
| Pages (from-to) | 343-347 |
| Number of pages | 5 |
| Journal | Pharmacology, Biochemistry and Behavior |
| Volume | 33 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 06-1989 |
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All Science Journal Classification (ASJC) codes
- Biochemistry
- Toxicology
- Pharmacology
- Clinical Biochemistry
- Biological Psychiatry
- Behavioral Neuroscience
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The effect of optical isomers of 3,4-methylenedioxymethamphetamine (MDMA) on stereotyped behavior in rats. / Hiramatsu, M.; Nabeshima, T.; Kameyama, T.; Maeda, Y.; Cho, A. K.
In: Pharmacology, Biochemistry and Behavior, Vol. 33, No. 2, 06.1989, p. 343-347.Research output: Contribution to journal › Article
TY - JOUR
T1 - The effect of optical isomers of 3,4-methylenedioxymethamphetamine (MDMA) on stereotyped behavior in rats
AU - Hiramatsu, M.
AU - Nabeshima, T.
AU - Kameyama, T.
AU - Maeda, Y.
AU - Cho, A. K.
PY - 1989/6
Y1 - 1989/6
N2 - The relative potencies of S(+)-, R(-)-3,4-methylenedioxymethamphetamine (MDMA) and S(+)-methylenedioxyamphetamine (MDA) in inducing stereotyped behavior were determined in comparison with p-chloroamphetamine. S(+)-MDMA was more potent than R(-)-MDMA in eliciting stereotyped behaviors such as sniffing, head-weaving, backpedalling and turning and wet-dog-shakes. These results are consistent with the actions of the drug on release of neurotransmitters in which the S(+) enantiomer is more potent. The desmethyl derivative of (+)MDMA, (+)MDA, was more potent than (+)MDMA in eliciting stereotyped behaviors, and produced wet-dog shake behavior.
AB - The relative potencies of S(+)-, R(-)-3,4-methylenedioxymethamphetamine (MDMA) and S(+)-methylenedioxyamphetamine (MDA) in inducing stereotyped behavior were determined in comparison with p-chloroamphetamine. S(+)-MDMA was more potent than R(-)-MDMA in eliciting stereotyped behaviors such as sniffing, head-weaving, backpedalling and turning and wet-dog-shakes. These results are consistent with the actions of the drug on release of neurotransmitters in which the S(+) enantiomer is more potent. The desmethyl derivative of (+)MDMA, (+)MDA, was more potent than (+)MDMA in eliciting stereotyped behaviors, and produced wet-dog shake behavior.
UR - http://www.scopus.com/inward/record.url?scp=0024366246&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024366246&partnerID=8YFLogxK
U2 - 10.1016/0091-3057(89)90511-X
DO - 10.1016/0091-3057(89)90511-X
M3 - Article
C2 - 2573077
AN - SCOPUS:0024366246
VL - 33
SP - 343
EP - 347
JO - Pharmacology Biochemistry and Behavior
JF - Pharmacology Biochemistry and Behavior
SN - 0091-3057
IS - 2
ER -