Abstract
The relative potencies of S(+)-, R(-)-3,4-methylenedioxymethamphetamine (MDMA) and S(+)-methylenedioxyamphetamine (MDA) in inducing stereotyped behavior were determined in comparison with p-chloroamphetamine. S(+)-MDMA was more potent than R(-)-MDMA in eliciting stereotyped behaviors such as sniffing, head-weaving, backpedalling and turning and wet-dog-shakes. These results are consistent with the actions of the drug on release of neurotransmitters in which the S(+) enantiomer is more potent. The desmethyl derivative of (+)MDMA, (+)MDA, was more potent than (+)MDMA in eliciting stereotyped behaviors, and produced wet-dog shake behavior.
| Original language | English |
|---|---|
| Pages (from-to) | 343-347 |
| Number of pages | 5 |
| Journal | Pharmacology, Biochemistry and Behavior |
| Volume | 33 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 06-1989 |
| Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Biochemistry
- Toxicology
- Pharmacology
- Clinical Biochemistry
- Biological Psychiatry
- Behavioral Neuroscience
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Hiramatsu, M., Nabeshima, T., Kameyama, T., Maeda, Y., & Cho, A. K. (1989). The effect of optical isomers of 3,4-methylenedioxymethamphetamine (MDMA) on stereotyped behavior in rats. Pharmacology, Biochemistry and Behavior, 33(2), 343-347. https://doi.org/10.1016/0091-3057(89)90511-X