The effect of oxatomide on reactive oxygen species (ROS) generated both by neutrophils and in a cell-free, xanthine-xanthine oxidase system was examined. The species investigated were superoxide radical anion (O-2), hydrogen peroxide (H2O2) and hydroxyl radical (OH·). Oxatomide significantly decreased neutrophil-generated O-2, H2O2 and OH· in a dose-dependent manner. H2O2 and OH· generated in a cell-free system were also reduced in the presence of oxatomide. The present study indicates that oxatomide decreases ROS generation presumably by inhibiting the neutrophil oxygen metabolism, and has the ability to scavenge H2O2 and OH·.
All Science Journal Classification (ASJC) codes
- Pharmaceutical Science