The effect of Oxatomide on Neutrophil Oxygen Radical Generation

Hirohiko Akamatsu; Yasuo Asada; Yoshiki Miyachi; Yukie Niwa

doi:10.1248/bpb.16.568

The effect of Oxatomide on Neutrophil Oxygen Radical Generation

Hirohiko Akamatsu, Yasuo Asada, Yoshiki Miyachi, Yukie Niwa

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

The effect of oxatomide on reactive oxygen species (ROS) generated both by neutrophils and in a cell-free, xanthine-xanthine oxidase system was examined. The species investigated were superoxide radical anion (O^-₂), hydrogen peroxide (H₂O₂) and hydroxyl radical (OH·). Oxatomide significantly decreased neutrophil-generated O^-₂, H₂O₂ and OH· in a dose-dependent manner. H₂O₂ and OH· generated in a cell-free system were also reduced in the presence of oxatomide. The present study indicates that oxatomide decreases ROS generation presumably by inhibiting the neutrophil oxygen metabolism, and has the ability to scavenge H₂O₂ and OH·.

Original language	English
Pages (from-to)	568-570
Number of pages	3
Journal	Biological and Pharmaceutical Bulletin
Volume	16
Issue number	6
DOIs	https://doi.org/10.1248/bpb.16.568
Publication status	Published - 1993
Externally published	Yes

All Science Journal Classification (ASJC) codes

Pharmacology
Pharmaceutical Science

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10.1248/bpb.16.568

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title = "The effect of Oxatomide on Neutrophil Oxygen Radical Generation",

abstract = "The effect of oxatomide on reactive oxygen species (ROS) generated both by neutrophils and in a cell-free, xanthine-xanthine oxidase system was examined. The species investigated were superoxide radical anion (O-2), hydrogen peroxide (H2O2) and hydroxyl radical (OH·). Oxatomide significantly decreased neutrophil-generated O-2, H2O2 and OH· in a dose-dependent manner. H2O2 and OH· generated in a cell-free system were also reduced in the presence of oxatomide. The present study indicates that oxatomide decreases ROS generation presumably by inhibiting the neutrophil oxygen metabolism, and has the ability to scavenge H2O2 and OH·.",

author = "Hirohiko Akamatsu and Yasuo Asada and Yoshiki Miyachi and Yukie Niwa",

year = "1993",

doi = "10.1248/bpb.16.568",

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journal = "Biological and Pharmaceutical Bulletin",

issn = "0918-6158",

publisher = "Pharmaceutical Society of Japan",

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T1 - The effect of Oxatomide on Neutrophil Oxygen Radical Generation

AU - Akamatsu, Hirohiko

AU - Asada, Yasuo

AU - Miyachi, Yoshiki

AU - Niwa, Yukie

PY - 1993

Y1 - 1993

N2 - The effect of oxatomide on reactive oxygen species (ROS) generated both by neutrophils and in a cell-free, xanthine-xanthine oxidase system was examined. The species investigated were superoxide radical anion (O-2), hydrogen peroxide (H2O2) and hydroxyl radical (OH·). Oxatomide significantly decreased neutrophil-generated O-2, H2O2 and OH· in a dose-dependent manner. H2O2 and OH· generated in a cell-free system were also reduced in the presence of oxatomide. The present study indicates that oxatomide decreases ROS generation presumably by inhibiting the neutrophil oxygen metabolism, and has the ability to scavenge H2O2 and OH·.

AB - The effect of oxatomide on reactive oxygen species (ROS) generated both by neutrophils and in a cell-free, xanthine-xanthine oxidase system was examined. The species investigated were superoxide radical anion (O-2), hydrogen peroxide (H2O2) and hydroxyl radical (OH·). Oxatomide significantly decreased neutrophil-generated O-2, H2O2 and OH· in a dose-dependent manner. H2O2 and OH· generated in a cell-free system were also reduced in the presence of oxatomide. The present study indicates that oxatomide decreases ROS generation presumably by inhibiting the neutrophil oxygen metabolism, and has the ability to scavenge H2O2 and OH·.

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DO - 10.1248/bpb.16.568

M3 - Article

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SN - 0918-6158

VL - 16

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EP - 570

JO - Biological and Pharmaceutical Bulletin

JF - Biological and Pharmaceutical Bulletin

IS - 6

ER -

The effect of Oxatomide on Neutrophil Oxygen Radical Generation

Abstract

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