The effect of roxithromycin on the generation of reactive oxygen species in vitro

H. Akamatsu, S. Nishijima, M. Akamatsu, I. Kurokawa, H. Sasaki, Y. Asada

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

The effect of roxithromycin (ROM), a new oral semisynthetic macrolide, on the generation of reactive oxygen species (ROS), using human neutrophils and a cell-free, xanthine-xanthine oxidase system was examined. The species investigated were the superoxide radical anion (O2-), hydrogen peroxide (H2O2), and the hydroxyl radical (OH·). ROM effectively inhibited the generation of O2-, H2O2 and OH· by human neutrophils. On the other hand, the drug did not markedly affect the ROS levels generated in the xanthine-xanthine oxidase system. The present study indicates that ROM may exert an anti-inflammatory action by inhibiting neutrophil oxygen radical generation at the sites of inflammation.

Original languageEnglish
Pages (from-to)27-32
Number of pages6
JournalJournal of International Medical Research
Volume24
Issue number1
DOIs
Publication statusPublished - 1996
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Cell Biology
  • Biochemistry, medical

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