The effect of serum carotenoids on atrophic gastritis among the inhabitants of a rural area in Hokkaido, Japan

Y. Ito, Koji Suzuki

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2 Citations (Scopus)

Abstract

A total of 206 residents (76 males and 130 females) of a rural area of Hokkaido, Japan, attending a health check in August, 1997, were studied to assess the relationship between serum carotenoids and atrophic gastritis (AG). Of the participants, 91 had AG, as indicated by their serum levels of pepsinogen I and pepsinogen II. Logistic regression analysis, after adjusting for gender and age, revealed that the odds ratios for serum carotenoid levels were lower for subjects with high serum levels of α-carotene (odds ratio, 0.41; 95% C.I., 0.19-0.88) and β-carotene (odds ratio, 0.41; 95% C.I., 0.18-0.91) than for those with low serum carotenoid levels. In addition, the odds ratios of subjects with high serum levels of β-cryptoxanthin (odds ratio, 0.60; 95% C.I., 0.28-1.31), provitamin A (odds ratio, 0.38; 95% C.I., 0.17-0.85), and retinol (odds ratio, 0.67; 95% C.I., 0.31-1.48) were found to be lower than the odds ratios for those with low serum levels. Odds ratios for subjects with high serum zeaxanthin/lutein levels were higher than odds ratios for those with low serum levels. These results suggest that frequent intake of foods rich in carotenoids with provitamin A activity may reduce the risk of AG.

Original languageEnglish
Pages (from-to)184-188
Number of pages5
JournalEnvironmental Health and Preventive Medicine
Volume6
Issue number3
DOIs
Publication statusPublished - 15-11-2001

Fingerprint

Atrophic Gastritis
Carotenoids
Japan
Odds Ratio
Serum
Pepsinogen C
Pepsinogen A
Lutein
Vitamin A
Eating
Logistic Models
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health

Cite this

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title = "The effect of serum carotenoids on atrophic gastritis among the inhabitants of a rural area in Hokkaido, Japan",
abstract = "A total of 206 residents (76 males and 130 females) of a rural area of Hokkaido, Japan, attending a health check in August, 1997, were studied to assess the relationship between serum carotenoids and atrophic gastritis (AG). Of the participants, 91 had AG, as indicated by their serum levels of pepsinogen I and pepsinogen II. Logistic regression analysis, after adjusting for gender and age, revealed that the odds ratios for serum carotenoid levels were lower for subjects with high serum levels of α-carotene (odds ratio, 0.41; 95{\%} C.I., 0.19-0.88) and β-carotene (odds ratio, 0.41; 95{\%} C.I., 0.18-0.91) than for those with low serum carotenoid levels. In addition, the odds ratios of subjects with high serum levels of β-cryptoxanthin (odds ratio, 0.60; 95{\%} C.I., 0.28-1.31), provitamin A (odds ratio, 0.38; 95{\%} C.I., 0.17-0.85), and retinol (odds ratio, 0.67; 95{\%} C.I., 0.31-1.48) were found to be lower than the odds ratios for those with low serum levels. Odds ratios for subjects with high serum zeaxanthin/lutein levels were higher than odds ratios for those with low serum levels. These results suggest that frequent intake of foods rich in carotenoids with provitamin A activity may reduce the risk of AG.",
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N2 - A total of 206 residents (76 males and 130 females) of a rural area of Hokkaido, Japan, attending a health check in August, 1997, were studied to assess the relationship between serum carotenoids and atrophic gastritis (AG). Of the participants, 91 had AG, as indicated by their serum levels of pepsinogen I and pepsinogen II. Logistic regression analysis, after adjusting for gender and age, revealed that the odds ratios for serum carotenoid levels were lower for subjects with high serum levels of α-carotene (odds ratio, 0.41; 95% C.I., 0.19-0.88) and β-carotene (odds ratio, 0.41; 95% C.I., 0.18-0.91) than for those with low serum carotenoid levels. In addition, the odds ratios of subjects with high serum levels of β-cryptoxanthin (odds ratio, 0.60; 95% C.I., 0.28-1.31), provitamin A (odds ratio, 0.38; 95% C.I., 0.17-0.85), and retinol (odds ratio, 0.67; 95% C.I., 0.31-1.48) were found to be lower than the odds ratios for those with low serum levels. Odds ratios for subjects with high serum zeaxanthin/lutein levels were higher than odds ratios for those with low serum levels. These results suggest that frequent intake of foods rich in carotenoids with provitamin A activity may reduce the risk of AG.

AB - A total of 206 residents (76 males and 130 females) of a rural area of Hokkaido, Japan, attending a health check in August, 1997, were studied to assess the relationship between serum carotenoids and atrophic gastritis (AG). Of the participants, 91 had AG, as indicated by their serum levels of pepsinogen I and pepsinogen II. Logistic regression analysis, after adjusting for gender and age, revealed that the odds ratios for serum carotenoid levels were lower for subjects with high serum levels of α-carotene (odds ratio, 0.41; 95% C.I., 0.19-0.88) and β-carotene (odds ratio, 0.41; 95% C.I., 0.18-0.91) than for those with low serum carotenoid levels. In addition, the odds ratios of subjects with high serum levels of β-cryptoxanthin (odds ratio, 0.60; 95% C.I., 0.28-1.31), provitamin A (odds ratio, 0.38; 95% C.I., 0.17-0.85), and retinol (odds ratio, 0.67; 95% C.I., 0.31-1.48) were found to be lower than the odds ratios for those with low serum levels. Odds ratios for subjects with high serum zeaxanthin/lutein levels were higher than odds ratios for those with low serum levels. These results suggest that frequent intake of foods rich in carotenoids with provitamin A activity may reduce the risk of AG.

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